Outcomes after kidney transplantation, let’s focus on the patients’ perspectives

Wang, Yiman; Snoep, Jaapjan D.; Hemmelder, Marc H; Bogt, Koen E.A. van der; Bos, Willem Jan W; Boog, Paul J.M. van der; Dekker, Friedo W.; Vries, Aiko P. J. de; Meuleman, Yvette

doi:10.1093/ckj/sfab008

Cited by 17 publications

(14 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A common and often neglected issue, posttransplant symptom burden has a negative impact on KT recipients’ ability to participate in physical and social activities of daily life (Ju et al, 2019). Multiple factors contribute to high symptom burden in KT recipients, including residual kidney dysfunction, comorbid conditions (e.g., diabetes and hypertension), and side-effects induced by immunosuppression (Sullivan et al, 2020; Wang et al, 2021). Furthermore, health care providers’ limited awareness of the negative effects of symptom burden after KT poses a major challenge to developing care improvement strategies for the posttransplant period.…”

mentioning

confidence: 99%

Sickness Symptoms in Kidney Transplant Recipients: A Scoping Review

Sung¹,

Hershberger

Lockwood³

2022

West J Nurs Res

View full text Add to dashboard Cite

Sickness symptoms (depressive symptoms, anxiety, and fatigue) are common among people with chronic illness, often presenting as a symptom cluster. Sickness symptoms persist in many patients with chronic kidney disease, even after kidney transplantation (KT); however, little is known about sickness symptom-induced burden in KT recipients. This scoping review synthesizes available evidence for sickness symptoms in KT recipients, including findings on symptom prevalence, predictors, outcomes, interrelationships, and clustering. Among 38 reviewed studies, none identified sickness symptoms as a cluster, but we observed interrelationships among the symptoms examined. Fatigue was the most prevalent sickness symptom, followed by anxiety and depressive symptoms. Predictors of these symptoms included demographic, clinical, and psychosocial factors, and health-related quality of life was the most researched outcome. Future research should use common data elements to phenotype sickness symptoms, include biological markers, and employ sophisticated statistical methods to identify potential clustering of sickness symptoms in KT recipients.

show abstract

mentioning

confidence: 99%

Sickness Symptoms in Kidney Transplant Recipients: A Scoping Review

Sung¹,

Hershberger

Lockwood³

2022

West J Nurs Res

View full text Add to dashboard Cite

show abstract

“…To the best of our knowledge, this study is the first one to report a positive impact of therapeutic education on transplant patients’ health‐related quality‐of‐life. HR‐QOL is a major outcome from the patient’s standpoint and is increasingly acknowledged as such by healthcare providers [29]. The mean mental and physical HR‐QOL scores at one year were overall higher in patients in the therapeutic education group.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic education as a tool to improve patient‐reported and clinical outcomes after renal transplantation: results of the EPHEGREN multicenter retrospective cohort study

et al. 2021

View full text Add to dashboard Cite

Summary Patients are not always aware of the inconveniences associated with renal transplantation, which they compare with a « rebirth », and from which they expect complete recovery. Therapeutic education is proposed to prepare patients for their life after transplantation. This study evaluated the impact of pretransplant therapeutic education on patient‐reported outcomes and rejection‐free survival over the first year. We collected data from 383 renal transplant patients followed‐up in seven centers. Patients who benefited from therapeutic education before transplantation (N = 182) were compared with patients who did not (N = 139) for quality‐of‐life, adherence and adverse events using the Pearson’s chi‐square test, one‐way ANOVA or t‐test. The association between therapeutic education and time to acute rejection was investigated using Cox models. The patients who benefited from therapeutic education reported adverse events less frequently (e.g., tremor: 9% vs. 32.4%, P = 0.01) and better quality‐of‐life (MCS‐QOL: 50.7 ± 8.1 vs. 47.7 ± 9.5, P = 0.02; PCS‐QOL: 49.1 ± 7.1 vs. 46.0 ± 9.2, P = 0.013). No difference was found on adherence. Rejection‐free survival was slightly better in the therapeutic education group (HR = 0.44, 95% CI = [0.19–1.01]). This multicenter retrospective cohort study suggests that integrating therapeutic education to care pathways entails clinical benefit, in terms of quality‐of‐life, self‐reported adverse events and rejection‐free survival. Randomized clinical trials are necessary to confirm this.

show abstract

“…It is demonstrated that KT provides superior life expectancy [61][62][63] and QoL [64][65][66] than dialysis. Nonetheless, returning to dialysis after a failed transplant entails a greater risk of death than starting RRT for the first time [11,40,43,67,68].…”

Section: Post-transplant Recipient and Allograft Survivalsmentioning

confidence: 99%

Peritoneal Dialysis for Potential Kidney Transplant Recipients: Pride or Prejudice?

et al. 2022

View full text Add to dashboard Cite

Kidney transplantation (KT) is recognized as the gold-standard of treatment for patients with end-stage renal disease. Additionally, it has been demonstrated that receiving a pre-emptive KT ensures the best recipient and graft survivals. However, due to an overwhelming discrepancy between the organs available and the patients on the transplant waiting list, the vast majority of transplant candidates require prolonged periods of dialysis before being transplanted. For many years, peritoneal dialysis (PD) and hemodialysis (HD) have been considered competitive renal replacement therapies (RRT). This dualistic vision has recently been questioned by evidence suggesting that an individualized and flexible approach may be more appropriate. In fact, tailored and cleverly planned changes between different RRT modalities, according to the patient’s needs and characteristics, are often needed in order to achieve the best results. While home HD is still under scrutiny in this particular setting, current data seems to favor the use of PD over in-center HD in patients awaiting a KT. In this specific population, the demonstrated advantages of PD are superior quality of life, longer preservation of residual renal function, lower incidence of delayed graft function, better recipient survival, and reduced cost.

show abstract

Outcomes after kidney transplantation, let’s focus on the patients’ perspectives

Cited by 17 publications

References 68 publications

Sickness Symptoms in Kidney Transplant Recipients: A Scoping Review

Sickness Symptoms in Kidney Transplant Recipients: A Scoping Review

Therapeutic education as a tool to improve patient‐reported and clinical outcomes after renal transplantation: results of the EPHEGREN multicenter retrospective cohort study

Peritoneal Dialysis for Potential Kidney Transplant Recipients: Pride or Prejudice?

Contact Info

Product

Resources

About