Outcomes after surgical ventricular restoration for ischemic cardiomyopathy

Stefanelli, Guglielmo; Bellisario, Alessandro; Meli, Marco; Chiurlia, Emilio; Barbieri, Andréa; Weltert, Luca

doi:10.1016/j.jtcvs.2020.04.167

Cited by 12 publications

(11 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results showed that the reduction in LV remodeling did not last for longer than 4 weeks and even declined after 1 week (31), and similar results were reported in mice with MI (15). These results are inconsistent with research on epicardial ventricular reconstruction in sheep (28) and SVR with a pursestring suture in rabbits (30) and a recent clinical report with a follow-up of 7 years indicating that patients with dilated ischemic cardiomyopathy have favorable long-term outcomes after SVR (32). Different surgical procedures lead to different prognoses.…”

Section: Discussionmentioning

confidence: 88%

A Modified Surgical Ventricular Reconstruction in Post-infarction Mice Persistently Alleviates Heart Failure and Improves Cardiac Regeneration

Yan

Yang

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Objectives: Large ventricular aneurysm secondary to myocardial infarction (MI) results in severe heart failure (HF) and limits the effectiveness of regeneration therapy, which can be improved by surgical ventricular reconstruction (SVR). However, the conventional SVR procedures do not yield optimal long-term outcome in post-MI rodents. We hypothesized that a modified SVR procedure without aggressive purse string suture would persistently alleviate HF and improve cardiac regeneration in post-MI mice.Methods: Adult male C57 mice were subjected to MI or sham surgery. Four weeks later, mice with MI underwent SVR or 2nd open-chest operation alone. SVR was performed by plicating the aneurysm with a single diagonal linear suture from the upper left ventricle (LV) to the right side of the apex. Cardiac remodeling, heart function and myocardial regeneration were evaluated.Results: Three weeks after SVR, the scar area, LV volume, and heart weight/body weight ratio were significantly smaller, while LV ejection fraction, the maximum rising and descending rates of LV pressure, LV contractility and global myocardial strain were significantly higher in SVR group than in SVR-control group. The inhibitory effects of SVR on LV remodeling and HF persisted for at least eight-week. SVR group exhibited improved cardiac regeneration, as reflected by more Ki67-, Aurora B- and PH3-positive cardiomyocytes and a higher vessel density around the plication area of the infarcted LV.Conclusions: SVR with a single linear suture results in a significant and sustained reduction in LV volume and improvement in both LV systolic and diastolic function as well as cardiac regeneration.

show abstract

Section: Discussionmentioning

confidence: 88%

A Modified Surgical Ventricular Reconstruction in Post-infarction Mice Persistently Alleviates Heart Failure and Improves Cardiac Regeneration

Yan

Yang

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…In ischemic cardiomyopathy, surgical coronary revascularization is beneficial to achieve favorable remodeling after surgery and avoid clinical outcomes [101]. Surgical ventricular reconstruction (SVR) such as the Dor procedure and its modifications contributed to improved long-term clinical outcomes with a reasonable perioperative risk [102]. Moreover, appropriate surgical maneuver of SVR had a significant impact on prognosis after surgery [102].…”

Section: Procedures On the Left Ventriclementioning

confidence: 99%

“…Surgical ventricular reconstruction (SVR) such as the Dor procedure and its modifications contributed to improved long-term clinical outcomes with a reasonable perioperative risk [102]. Moreover, appropriate surgical maneuver of SVR had a significant impact on prognosis after surgery [102]. However, the clinical advantage of SVR concomitant with coronary artery bypass graft was not demonstrated in the STICH (Surgical Treatment for ischemic Heart Failure) trial, which was a randomized study of SVR in ischemic cardiomyopathy [103].…”

Section: Procedures On the Left Ventriclementioning

confidence: 99%

Cardiomyopathy: Recent Findings

Yamada¹,

Sugi²,

Nakajima³

et al. 2021

Cardiomyopathy - Disease of the Heart Muscle

View full text Add to dashboard Cite

In 1957, Wallace Brigden published an article on the Lancet, such as uncommon myocardial diseases: the non-coronary cardiomyopathy. In this article, he mentioned that “the term cardiomyopathy is used here to indicate isolated noncoronary myocardial disease.” Then “cardiomyopathy” has become a commonly used term in the cardiovascular field, and has been defined and classified by many researchers and academic societies. The basic concept of cardiomyopathy is a group of diseases with mechanical and/or electrophysiological dysfunction of the ventricles, and cardiomyopathy is distinguished with normal ischemic heart disease, valvular disease, and hypertensive heart disease. It can often cause heart failure and cardiac death. In this chapter, we describe the classification, details, and treatment of cardiomyopathy, and iPS cell from pathological myocardium.

show abstract

“…In an insight of the Surgical Treatment of Ischemic Heart Failure trial, Michler and colleagues 6 identified a 30% volume reduction threshold for better survival. In the current issue of the Journal, Stefanelli and colleagues 7 add evidence on the importance of performing a left ventricular volume reduction greater than 35% for survival benefits. Better longterm results were reached in those patients receiving the modified SVR technique compared with the Dor technique.…”

mentioning

confidence: 99%

Commentary: Let's start again!

Miceli

2022

The Journal of Thoracic and Cardiovascular Surgery

View full text Add to dashboard Cite

Outcomes after surgical ventricular restoration for ischemic cardiomyopathy

Cited by 12 publications

References 28 publications

A Modified Surgical Ventricular Reconstruction in Post-infarction Mice Persistently Alleviates Heart Failure and Improves Cardiac Regeneration

A Modified Surgical Ventricular Reconstruction in Post-infarction Mice Persistently Alleviates Heart Failure and Improves Cardiac Regeneration

Cardiomyopathy: Recent Findings

Commentary: Let's start again!

Contact Info

Product

Resources

About