Outcomes Analysis of Voice and Quality of Life in Patients With Laryngeal Cancer

Stewart, Michael G.; Chen, Amy Y.; Stach, Carol B.

doi:10.1001/archotol.124.2.143

Cited by 96 publications

(98 citation statements)

References 17 publications

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“…Furthermore, several studies on the inXuence of voice problems on quality of life revealed that in 27 up to 58% of the patients experienced diYculties in communication abilities leading to a disrupted social life [3,8,12,17,[19][20][21][22]25]. To enable quick screening on voice problems, a short 5-item voicescreening questionnaire was developed and validated, which proved to be feasible in clinical practice [22].…”

Section: Introductionmentioning

confidence: 99%

“…A more detailed multidimensional voice analysis protocol is however recommended for monitoring voice intervention and for research purposes [24], including a structured questionnaire such as the Voice handicap index (VHI). The VHI is a validated 30-item questionnaire measuring psychosocial handicapping eVects of voice disorders [7] and is used in several studies on patients after treatment for early glottic cancer with mean VHI scores ranging from 12 to 34 points [3,8,12,19]. Most of these studies include patients with and without deviant voice quality and mean VHI data are therefore not informative on the amount of problems that patients with voice impairment after oncological treatment encounter in daily life.…”

Section: Introductionmentioning

confidence: 99%

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Voice in early glottic cancer compared to benign voice pathology

Gogh

Mahieu

Kuik

et al. 2007

Eur Arch Otorhinolaryngol

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The purpose of this study is to compare (Dutch) Voice Handicap Index (VHIvumc) scores from a selected group of patients with voice problems after treatment for early glottic cancer with patients with benign voice disorders and subjects from the normal population. The study included a group of 35 patients with voice problems after treatment for early glottic cancer and a group of 197 patients with benign voice disorders. Furthermore, VHI scores were collected from 123 subjects randomly chosen from the normal population. VHI reliability was high with high internal consistency and test-retest stability. VHI scores of glottic cancer patients were similar to those of patients with voice problems due to benign lesions. Both groups of patients were clearly deviant from the normal population. Within the normal population, 16% appeared to have not-normal voices. Based on ROC curves a cut-oV score of 15 points was deWned to identify patients with voice problems in daily life. A clinical relevant diVerence score of 10 points was deWned to be used for individual patients and of 15 points to be used in study designs with groups. Patients with voice problems after treatment for early glottic cancer encounter the same amount of problems in daily life as the other voiceimpaired patients. The VHI proved to be an adequate tool for baseline and eVectiveness measurement of voice.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Voice in early glottic cancer compared to benign voice pathology

Gogh

Mahieu

Kuik

et al. 2007

Eur Arch Otorhinolaryngol

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“…All methods of vocal rehabilitation have one major goal, that is, to achieve patient satisfaction in meeting their long-term communication needs [8]. While most literature has emphasized the immediate outcomes of alaryngeal speech acquisition, there is still a paucity of information available concerning the long-term maintenance and functional voice outcomes of the various modes of voice rehabilitation offered to both total laryngectomy and pharyngolaryngectomy patient populations.…”

Section: Introductionmentioning

confidence: 99%

Differential Modes of Alaryngeal Communication and Long-Term Voice Outcomes following Pharyngolaryngectomy and Laryngectomy

Ward

Koh²,

Frisby³

et al. 2003

Folia Phoniatr Logop

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Patterns of vocal rehabilitation for 37 pharyngolaryngectomy patients and 55 total laryngectomy patients over a 5-year period were compared. An electrolarynx (EL) was introduced as the initial communication mode immediately after surgery for 98% of patients, with 30% of pharyngolaryngectomy and 74% of laryngectomy patients subsequently developing tracheoesophageal speech (TES) as their primary mode of communication. Follow-up with 14 of 37 pharyngolaryngectomy patients and 36 of 55 laryngectomy patients was conducted 1–6 years following surgery and revealed that 90% of the pharyngolaryngectomy patients maintained the use of TES in the long term compared to 69% of the laryngectomy group. Long-term outcomes relating to communication disability and handicap did not differ significantly between the two surgical groups, however the laryngectomy patients had significantly higher levels of wellbeing. Across the whole group of patients, statistical comparison revealed that patients using TES had significantly lower levels of disability, handicap and distress than EL users. Considering that lower levels of disability, handicap and distress are associated with TES, and the data supports that suitably selected patients can maintain functional TES in the long term, increased application of this form of communication rehabilitation should be encouraged where viable for the pharyngolaryngectomy population.

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“…Even though ELS is quicker, which reduces cost considerably, many institutions prefer to use radiotherapy (1)(2)(3)(4)(5). This choice depends on the fact that the voice function and quality are better preserved after treatment (6)(7)(8)(9). Starting from this evidence many efforts have been made to find a better RT therapeutic plan.…”

Section: Introductionmentioning

confidence: 99%

The impact of conventional or hypofractionated radiotherapy on voice quality and oncological outcome in patients with early glottic cancer

Nicola

Gravina²,

Marampon³

et al. 2010

Oncol Rep

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Abstract. The hypothesis being tested in this study is that hypofractionated radiotherapy is well tolerated and not lower in terms of oncological outcome than conventional radiotherapy. Forty patients with histologically proven glottic cancer were included in the analysis. Twenty-two were treated by hypofractionated radiotherapy (3D-HFRT) (25 fractions of 2.4 Gy delivered daily to a total dose of 60 Gy). This group was retrospectively compared to 18 subjects who met the same inclusion criteria and who were treated with conventional radiotherapy (3D-CRT) (33 fractions of 2 Gy delivered daily to a total dose of 66 Gy). One year after RT treatment in 10 patients (5 in the Arm-1 and 5 in the Arm-2) mild dysphonia persisted. The other patients achieved a complete recovery of the overall quality of voice with no significant difference documented between the two groups. At 3 years the local control rate was 100% for the patients treated with hypofractionated radiotherapy and 96% for the patients treated with conventional regimen. The statistical analysis did not show any significant difference in local control between the two groups (p=0.45). No significant acute and late toxicity was documented in both groups. Subjects with early glottic cancer seem to experience comparable levels of morbidity irrespective whether they were treated by hypofractionated or conventional conformal therapy without any worsening of the tumor local control. Thus, we provide clinical evidence to justify trends already emerging toward hypofractionated regimens in early glottic cancer.

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Outcomes Analysis of Voice and Quality of Life in Patients With Laryngeal Cancer

Cited by 96 publications

References 17 publications

Voice in early glottic cancer compared to benign voice pathology

Voice in early glottic cancer compared to benign voice pathology

Differential Modes of Alaryngeal Communication and Long-Term Voice Outcomes following Pharyngolaryngectomy and Laryngectomy

The impact of conventional or hypofractionated radiotherapy on voice quality and oncological outcome in patients with early glottic cancer

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