Outcomes and experiences of using oral voriconazole with or without concomitant topical agents to treat refractory vulvovaginal yeast infections

Abstract

Background We describe 11 cases of refractory vulvovaginal yeast infections (RVVYI) treated using oral voriconazole with or without concomitant topical agents. Methods Retrospective case-note review of all women prescribed oral voriconazole to treat RVVYI in five Sexual Health Clinics from Jan 2010-March 2020. Demographic details, clinical features, diagnostic results and treatment outcomes were collected. Results 11 women with vulvovaginal symptoms for a median of 1 year were treated with voriconazole. RVVYI was diagnosed clinically and confirmed on microscopy and culture with speciation. 10/11 isolates were fluconazole resistant, 1 intermediately sensitive, 10/11 were either fully or intermediately sensitive to voriconazole. All had received prior fluconazole and clotrimazole and 10/11 had used at least 2-weeks of one or more second-line antifungals with non-clearance of the yeast. Oral voriconazole 400 mg BD day-1, then 200 mg BD 13-days was prescribed and 10/11 women completed the course. Concomitant topical treatment was used by 6/11. Liver and renal function were monitored at 0, 7, 14 days. One woman stopped voriconazole after 5-days due to perioral tingling. Other transient side-effects were nausea ( n = 2), photosensitivity, muscle aches, hair thinning (all n = 1), peripheral visual disturbance ( n = 2). 8/11 experienced both symptom reduction and yeast clearance. Two women had an initial partial response but experienced resolution of symptoms following a second course of voriconazole. Conclusions Our observational data adds to the limited evidence to support voriconazole treatment for RVVYI. A 2-week course of voriconazole was tolerated and completed by 10/11 women. Eight women, five using concomitant topical agents, achieved mycological cure.

Treatment of Vulvovaginal Candidiasis—An Overview of Guidelines and the Latest Treatment Methods

“…One woman experienced tingling around the mouth after 5 days of treatment, which resolved within 24 h after taking the last dose of voriconazole. The study showed that voriconazole, alone or in combination with topical agents, may be effective in the treatment of refractory VVC [ 58 ].…”

Voriconazole plus flucytosine is not superior to amphotericin B deoxycholate plus flucytosine as an induction regimen for cryptococcal meningitis treatment

“…6 Some studies have shown that voriconazole could be used as a salvage therapy for refractory fungal infections, including CM. [7][8][9] The successful use of voriconazole for the treatment of CM has only been reported in a few cases. [10][11][12] We conducted the current retrospective study to compare the efficacy and side effects of Voriconazole + 5-FC (Vori + 5-FC) and AmBd + 5-FC as induction treatments to determine whether Voriconazole-based therapy was superior to AmBd-based therapy in CM patients.…”

“…Voriconazole is a powerful antifungal drug against a broad spectrum of fungi, such as Aspergillus , Candida and Cryptococcus neoformans 6 . Some studies have shown that voriconazole could be used as a salvage therapy for refractory fungal infections, including CM 7–9 . The successful use of voriconazole for the treatment of CM has only been reported in a few cases 10–12 .…”