Outcomes and Indications of Segmental Pancreatectomy

Shibata, Satoshi; Sato, Tsutomu; Andoh, Hideaki; Yasui, Ouki; Yoshioka, Masato; Kurokawa, Toshiaki; Watanabe, Go; Ise, Norihito; Kotanagi, Hitoshi; Asanuma, Yoshihiro; Koyama, Kenji

doi:10.1159/000075826

Cited by 44 publications

(45 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This suggests that a greater amount of normal pancreatic tissue was removed in the SPDP group. Similar findings were reported in other previous studies comparing CP to distal pancreatectomy [12,29,33]. A correlation of the length of resected pancreas with development of diabetes has been shown [29].…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Central Pancreatectomy versus Spleen-Preserving Distal Pancreatectomy: A Comparative Analysis of Early and Late Postoperative Outcomes

et al. 2012

View full text Add to dashboard Cite

Background/Aim: The aim of the present study is to compare the postoperative and long-term outcomes of central pancreatectomy (CP) and spleen-preserving distal pancreatectomy (SPDP). Methods: Clinical, pathological and long-term data were compared between 22 patients who underwent CP and 25 patients who underwent SPDP (2002–2012). Results: The median length of resected pancreas was 8.5 cm in the SPDP group and 5 cm in the CP group (p < 0.001). The median estimated blood loss was significantly lower in the CP group (p = 0.019). Morbidity was 50% for CPs and 40% for SPDPs (p = 0.564). The rate of pancreatic fistulae was 36% for CPs and 40% for SPDPs (p = 0.530). The rate of new-onset diabetes was nil in the successful CP group and 16% in the SPDP group (p = 0.111). Conclusion: Morbidity and pancreatic fistula rates are not higher after CP when compared to SPDP. The loss of normal pancreatic tissue is significantly lower for CP, and thus there is potentially better preservation of the pancreatic endocrine functions. CP should be considered only in selected cases when preservation of the pancreas is of utmost importance, especially for lesions situated at the level of the pancreatic neck.

show abstract

Section: Discussionsupporting

confidence: 89%

“…In such cases, distal pancreatectomy implies removal of a significant amount of normal pancreatic tissue, especially for lesions located in the pancreatic neck [29], and can potentially lead to endocrine or exocrine pancreatic insufficiency in the long-term. Thus, CP appears to be a promising alternative in selected cases [30,31].…”

Section: Discussionmentioning

confidence: 99%

Central Pancreatectomy versus Spleen-Preserving Distal Pancreatectomy: A Comparative Analysis of Early and Late Postoperative Outcomes

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Japanese patients generally tend to stay in the hospital until all drains and/or tubes are removed and they feel completely well, even if they can leave the hospital [22]. …”

Section: Discussionmentioning

confidence: 99%

Role of Medial Pancreatectomy in the Management of Intraductal Papillary Mucinous Neoplasms and Islet Cell Tumors of the Pancreatic Neck and Body

et al. 2008

View full text Add to dashboard Cite

Background/Aim: Medial pancreatectomy has been applied as a safe and effective alternative in benign diseases located in the pancreatic neck or body. However, the role of this procedure remains controversial. We investigate outcomes using this method in 14 patients. Methods: Fourteen consecutive patients underwent medial pancreatectomy. The surgical indications, postoperative outcomes, and pathologic characteristics were retrospectively analyzed. Results: Among 10 patients with intraductal papillary mucinous neoplasms, 3 patients had minimally invasive adenocarcinoma, and 3 had adenocarcinoma in situ. Four patients required an additional resection of the pancreatic remnant because of a positive surgical margin. A medial pancreatectomy was converted to a distal pancreatectomy in 1 patient with adenocarcinoma in situ. Three patients with islet cell tumor and 1 patient with solid pseudopapillary tumor had no malignant disease. Postoperative complications occurred in 6 patients (43%): 5 had pancreatic fistulas and 1 had a gastric ulcer. All of the patients are doing well without recurrence. Conclusions: A medial pancreatectomy is a safe and effective alternative for the treatment of intraductal papillary mucinous neoplasm, islet cell tumor, or solid pseudopapillary tumor located in the neck or body of the pancreas. However, a precise preoperative and intraoperative assessment including an examination of frozen sections is mandatory to select the appropriate surgical procedure.

show abstract

“…This fact raises the possibility that pancreatectomies may impair glucose metabolism more frequently in Asian patients. Although the available data was limited and was not adjusted for clinical parameters like age, sex, primary pancreatic disorders and preoperative glucose metabolism, Shibata et al [37] reported that 3 of 7 Japanese patients who received a distal pancreatectomy developed substantial diabetes. In the present study, at least 5 of the 7 patients who received a partial pancreatectomy became diabetic.…”

Section: Discussionmentioning

confidence: 99%

Long-term Follow-up of Patients with Multiple Endocrine Neoplasia Type 1

et al. 2007

View full text Add to dashboard Cite

Abstract. Whether early surgical treatment of non-functioning pancreas islet cell tumor (NFPT) provides a favorable quality of life and life expectancy in patients with multiple endocrine neoplasia type 1 (MEN1) remains controversial. We analyzed the long-term clinical courses and surgical outcomes of 14 Japanese patients with MEN1-associated NFPTs. NFPTs smaller than 20 mm in diameter did not show any apparent growth over a long monitoring period. Furthermore, these small NFPTs did not metastasize to regional lymph nodes or the liver. On the other hand, the development of additional NFPTs or metastasis was found in five of six patients with large (35 mm or larger) NFPTs. Among the seven patients who underwent a partial pancreatectomy, six patients developed impaired glucose tolerance or diabetes. The accumulation of more prospective data is needed to clarify the optimal surgical indications for patients with NFPTs, especially among the Japanese population, which has a relatively low insulin secretion potency compared with nonHispanic white and African-American populations.

show abstract

Outcomes and Indications of Segmental Pancreatectomy

Cited by 44 publications

References 12 publications

Central Pancreatectomy versus Spleen-Preserving Distal Pancreatectomy: A Comparative Analysis of Early and Late Postoperative Outcomes

Central Pancreatectomy versus Spleen-Preserving Distal Pancreatectomy: A Comparative Analysis of Early and Late Postoperative Outcomes

Role of Medial Pancreatectomy in the Management of Intraductal Papillary Mucinous Neoplasms and Islet Cell Tumors of the Pancreatic Neck and Body

Long-term Follow-up of Patients with Multiple Endocrine Neoplasia Type 1

Contact Info

Product

Resources

About