Outcomes and prognostic factors for parotid acinic cell Carcinoma: A National Cancer Database study of 2362 cases

Scherl, Claudia; Kato, Masanari; Erkul, Evren; Graboyes, Evan M.; Nguyen, Shaun A.; Angela, C.; Morgan, Patrick F; Day, Terry A.

doi:10.1016/j.oraloncology.2018.05.002

Cited by 40 publications

(75 citation statements)

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“…Several population‐based analyses of AciCC have been reported. On multivariable analysis of 2362 patients with AciCC from the National Cancer Database, tumor size between 3 and 6 cm was identified as a significant high‐risk feature (hazard ratio, 1.53) 7 . In our study, tumor ≥ 3 cm (50% vs 100%; P = 0.025; Figure 1B) was a significant prognostic indicator for DFS, consistent with the conclusions of Neskey et al 28 .…”

Section: Discussionsupporting

confidence: 90%

“…Acinic cell carcinoma (AciCC) is a sparse, low‐grade malignant epithelial carcinoma of the salivary glands, with an average annual incidence of 0.13 cases per 100 000 individuals, 1 and is far less common in children than adults 2‐6 . The reported five‐year survival rate of patients with AciCC ranges from 88.6% to 90% 7‐9 . Due to its rarity, previous studies of AciCC in children and adolescents have predominately been reported as case series, 10‐14 and it is challenging to develop a consensus on its management.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of surgery combined with postoperative ¹²⁵I interstitial brachytherapy for treatment of acinic cell carcinoma of the parotid gland in children and adolescents

Zhang

Lyu

et al. 2020

Pediatric Blood & Cancer

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Background: Acinic cell carcinoma (AciCC) is rare in children; therefore, reaching a consensus on its management is challenging and radiotherapy is limited by concerns about long-term toxicity.The purpose of this study is to analyze the effectiveness and safety of surgery plus postoperative 125 I interstitial brachytherapy (IBT) for children and adolescents with AciCC of the parotid gland (PG) treated at a single institution.Procedure: Sixteen patients ≤ 18 years old with AciCC of the PG treated with surgery plus 125 I IBT from 2007 to 2018 were included. Surgery was the primary treatment; ten patients underwent total gross excision and six subtotal gross excision. The matched peripheral dose was 60-120 Gy.Overall survival, disease-free survival (DFS), local control rate, distant metastasis, and radiationassociated toxicities were analyzed, and factors influencing outcomes were evaluated.Results: During follow-up (1.8-12.6 years; mean, 6.3 years), lymph node metastasis was observed in one case, 2.6 years after 125 I IBT treatment. The five-year overall and DFS rates were 100% and 91.7%, respectively. On univariate analysis, tumor size ≥ 3 cm (100% vs 50%; P = 0.025) and extraglandular extension (100% vs 50%; P = 0.025) were significant prognostic indicators for DFS.No severe radiation-associated complications occurred. Conclusions:Children and adolescents with AciCC of the PG with high-risk features can be managed using surgery plus postoperative 125 I IBT with excellent local control. Radiation-related complications were minor. Patients with facial nerve involvement can have their facial nerves preserved. Residual tumors can be safely managed using adjuvant 125 I IBT. K E Y W O R D Sacinic cell carcinoma, adolescent, brachytherapy, children, parotid gland

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Efficacy of surgery combined with postoperative ¹²⁵I interstitial brachytherapy for treatment of acinic cell carcinoma of the parotid gland in children and adolescents

Zhang

Lyu

et al. 2020

Pediatric Blood & Cancer

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“…Salivary gland malignant tumours account for 1-3% of head and neck cancers [1]. Acinar cell carcinoma (ACC) is an uncommon malignant tumour, and its predominant site of origin is salivary glands in the head and neck region [2]. Approximately 80% of ACC originates in the parotid gland; the remaining disease originates in the submandibular and sublingual glands, and there are reports involving the hypopharynx, lip, thyroid, tongue and tonsil [3].…”

Section: Introductionmentioning

confidence: 99%

Head & neck acinar cell carcinoma: a population-based study using the seer registry

et al. 2020

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Background: To explore the clinicopathologic characteristics, treatment and prognostic factors of head and neck acinar cell carcinoma (HNACC) comprehensively. Methods: A population-based study was conducted using data from the Surveillance, Epidemiology, and End Results database (1975-2016). Overall survival (OS) and HNACC-specific survival of patients with different clinicopathologic variables were compared using the Kaplan-Meier method and Cox multivariate regression. Results: A total of 2624 primary HNACC cases (1052 males, 1572 females) were identified. There was a significant difference in gender distribution. Among the total cohort, 2416 cases originated from salivary glands, including 2325 parotid gland ACC cases. Regardless of confounding factors, the 10-year and 20-year disease-specific survival (DSS) was 93.6 and 90%, respectively. Surgery was favourably associated with better DSS and OS [HR = 0.13, P = 0.0092 and HR = 0.23, P = 0.0203]. Gender was the only demographic independent prognostic factor for both DSS and OS [Male vs female, HR = 3.3, P = 0.0028 for DSS; HR = 2.44, P = 0.0376 for OS]. Higher pathological grade was adversely associated with DSS and OS [Grade II, HR = 4.03, P = 0.0444; Grade III + IV, HR = 35.64, P = 0.0000 for DSS; Grade III + IV, HR = 4.49, P = 0.0000 for OS, Grade I as reference]. In addition, TNM/AJCC stage was commonly associated with prognosis. Conclusion: Surgery was the only favourable prognostic indicator for both DSS and OS. Gender, age, pathological differentiation and TNM/AJCC stage were independent prognostic factors for survival.

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“…In summary, despite the limitations of the incomplete data and of the study itself, to the best of our knowledge the present study is the rst investigation to use a large study population and a long follow-up time to de ne the clinicopathologic characteristics and identify the prognostic indicators of ACC in the head and neck region. Three earlier reports described ACC cases reported in the National Cancer Database and the SEER database [2,5,14]. Although there is overlap among the study samples, the conclusions are complementary and enhance each other due to the different research intentions.…”

Section: Discussionmentioning

confidence: 86%

Head & neck acinar cell carcinoma: a population-based study using the seer registry

Yibulayin

Feng

Wang

et al. 2020

Preprint

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Background: to explore the clinicopathologic characteristics, treatment and prognostic factors of head and neck acinar cell carcinoma (HNACC) comprehensively. Methods: A population-based study was conducted using data from the Surveillance, Epidemiology, and End Results database (1975- 2016). Overall survival (OS) and HNACC-specific survival of patients with different clinicopathologic variables were compared using the Kaplan-Meier method and Cox multivariate regression. Results: A total of 2624 primary HNACC cases (1052 males, 1572 females) were identified. There was a significant difference in gender distribution. Among the total cohort, 2416 cases originated from salivary glands, including 2325 parotid gland ACC cases. Regardless of confounding factors, the 10-year and 20-year disease-specific survival (DSS) was 93.6% and 90%, respectively. Surgery was favourably associated with better DSS and OS [HR = 0.13, P = 0.0092 and HR = 0.23, P = 0.0203]. Gender was the only demographic independent prognostic factor for both DSS and OS [male vs female, HR = 3.3, P = 0.0028 for DSS; HR = 2.44, P = 0.0376 for OS]. Higher pathological grade was adversely associated with DSS and OS [Grade II, HR= 4.03, P = 0.0444; Grade III + IV, HR = 35.64, P = 0.0000 for DSS; Grade III + IV, HR = 4.49, P = 0.0000 for OS, Grade I as reference]. In addition, TNM/AJCC stage was commonly associated with prognosis. Conclusion: Surgery was the only favourable prognostic indicator for both DSS and OS. Gender, age, pathological differentiation and TNM/AJCC stage were independent prognostic factors for survival.

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Outcomes and prognostic factors for parotid acinic cell Carcinoma: A National Cancer Database study of 2362 cases

Cited by 40 publications

References 30 publications

Efficacy of surgery combined with postoperative ¹²⁵I interstitial brachytherapy for treatment of acinic cell carcinoma of the parotid gland in children and adolescents

Efficacy of surgery combined with postoperative ¹²⁵I interstitial brachytherapy for treatment of acinic cell carcinoma of the parotid gland in children and adolescents

Head & neck acinar cell carcinoma: a population-based study using the seer registry

Head & neck acinar cell carcinoma: a population-based study using the seer registry

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Outcomes and prognostic factors for parotid acinic cell Carcinoma: A National Cancer Database study of 2362 cases

Cited by 40 publications

References 30 publications

Efficacy of surgery combined with postoperative 125I interstitial brachytherapy for treatment of acinic cell carcinoma of the parotid gland in children and adolescents

Efficacy of surgery combined with postoperative 125I interstitial brachytherapy for treatment of acinic cell carcinoma of the parotid gland in children and adolescents

Head & neck acinar cell carcinoma: a population-based study using the seer registry

Head &amp; neck acinar cell carcinoma: a population-based study using the seer registry

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Efficacy of surgery combined with postoperative ¹²⁵I interstitial brachytherapy for treatment of acinic cell carcinoma of the parotid gland in children and adolescents

Efficacy of surgery combined with postoperative ¹²⁵I interstitial brachytherapy for treatment of acinic cell carcinoma of the parotid gland in children and adolescents

Head & neck acinar cell carcinoma: a population-based study using the seer registry