Outcomes and Prognostic Factors of Primary Urethral Cancer

Sui, Wilson; RoyChoudhury, Arindam; Wenske, Sven; DeCastro, G. Joel; McKiernan, James M.; Anderson, Christopher B.

doi:10.1016/j.urology.2016.09.042

Cited by 49 publications

(41 citation statements)

References 25 publications

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“…We show here that there were no significant differences in survival among patients with SCC, TCC, or Ac. Surprisingly, CSS was significantly worse for women with Ac, which is consistent with a study of 869 women with PUC11 and may be explained by differences in sex-specific anatomy, tumor biology, tumor location, positive lymph-node status, and marital status. Further, men with Ac experience longer survival,12 which supports our results.…”

Section: Discussionsupporting

confidence: 88%

“…PUC is a relatively rare cancer that accounts for <1% of all malignancies,2 and there are certain differences between clinicopathological findings for women and men with PUC 2–4,11,12. Here, we utilized SEER data to investigate the differences in clinicopathological characteristics and survival between women and men, and we evaluated prognostic factors as well.…”

Section: Discussionmentioning

confidence: 99%

“…Disparities were also associated with the quality of medical care, particularly in the US, for economically disadvantaged patients. However, the roles of racial disparities in influencing the outcomes of patients with PUC have been insufficiently characterized, and this subject is thus controversial 11,16–18. For example, the survival of black women with PUC is significantly shorter 19.…”

Section: Discussionmentioning

confidence: 99%

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Sex-related differences in clinicopathological features and survival of patients with primary urethral carcinoma: a population-based study

Wei¹,

Wu²,

Xu³

et al. 2017

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PurposeTo analyze the Surveillance, Epidemiology, and End Results (SEER) database to determine the effects of sex and prognostic factors on the survival of patients with primary urethral carcinoma (PUC).Materials and methodsWe selected 453 patients diagnosed with PUC from 2004 to 2013 from the SEER database. Statistical analysis was used to identify sex-specific differences associated with tumor characteristics and cancer-specific survival (CSS) and overall survival (OS).ResultsCompared with men, there was a higher proportion of black women, more negative lymph-node status, higher American Joint Committee on Cancer (AJCC) stage, more advanced T3 stage, more with adenocarcinoma (Ac), and fewer with squamous cell carcinoma (SCC) or transitional cell carcinoma (TCC). Among women, black race and M1 stage were associated with shorter CSS and OS, respectively. In addition, surgery was associated with longer OS in women. Among men, AJCC III and IV and M1 stages were associated with shorter CSS and OS. In addition, age >75 years associated with shorter OS in men.ConclusionBlack race was associated with shorter OS and CSS of women, and surgery was associated with longer OS of women. Among men, AJCC stage III and IV were associated with shorter OS and CSS. Age >75 years was associated with shorter OS in men only. Women with Ac experienced poor CSS compared with men. Men with TCC experienced worse CSS compared with those with Ac or SCC.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Sex-related differences in clinicopathological features and survival of patients with primary urethral carcinoma: a population-based study

Wei¹,

Wu²,

Xu³

et al. 2017

OTT

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“…PCU had been classified according to WHO as urothelial (UCC), squamous (SCC) and adenocarcinoma (AC) of either unspecified or enteric type, with the remaining being extremely rare clear cell and adenoid cystic carcinomas [13]. UCC is the most frequent PCU, but most of the described PCU present with mixed urothelial and squamous differentiation [3,14].…”

Section: Discussionmentioning

confidence: 99%

Primary urethral carcinoma – unexpected cause of urethral stricture. Case report and review of the literature.

et al. 2019

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Primary cancer of urethra (PCU) is one of rarest malignancies of the urinary tract. In early stages this type of cancer presents non specific symptoms which can be mistaken with more common urethral strictures. That is why the PCU is frequently recognize in a locally advanced stage. The basic tool used in the diagnosis is MRI, but ultrasonography can be also used at the beginning of diagnosis. We present the case of 66-year old patient with PCU, initially diagnosed due to urethral stricture. We report probably the first case of well documented sonourethrography findings in PCU.

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“…Most patients are diagnosed with advanced disease [2–6]. These tumours have an aggressive natural history, with reported 5‐year overall survival rates of 32–54% [2,3,7,8]. Patient and tumour characteristics associated with oncological outcome include sex, age, tumour location, stage and nodal status [2,3,5,9,10].…”

Section: Introductionmentioning

confidence: 99%

Primary urethral cancer: treatment patterns and associated outcomes

et al. 2020

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Objectives To evaluate treatment patterns and associated outcomes of patients with urethral cancer. Patients and Methods After obtaining institutional review board approval we identified 165 patients treated for primary urethral cancer between 1956 and 2017. Treatment included monotherapy (surgery or radiation), dual therapy (surgery+radiation, surgery+chemotherapy, or chemotherapy+radiation) or triple therapy (surgery+radiation+chemotherapy). Rates of different treatments were described by treatment year. The association between treatment type and outcomes was evaluated with multivariable Cox regression models, adjusting for disease characteristics. Results The study cohort included 74 men and 91 women, with a median age of 61 years. Common histologies were squamous cell (36%), urothelial (27%) and adenocarcinoma (25%). At presentation, 72% of patients had invasive disease, 24% had nodal involvement, and 5% had metastases. Treatment included monotherapy (57%), dual therapy (21%), and triple therapy (10%). The use of monotherapy decreased over time, while rates of dual therapy remained consistent, and rates of triple therapy increased. The median follow‐up was 4.7 years. Estimated 5‐year local recurrence‐free, disease‐specific and overall survival were 51%, 48% and 41%, respectively. Monotherapy was associated with decreased local recurrence‐free survival after adjusting for stage, histology, sex and year of treatment (P = 0.017). There was no evidence that treatment type was associated with distant recurrence, cancer‐specific or overall survival. Conclusions We found preliminary evidence that multimodal therapy, more commonly used in recent years, was of benefit in patients with primary urethral cancer. This finding should be confirmed in further studies involving multiple centres because of the low incidence of the disease.

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Outcomes and Prognostic Factors of Primary Urethral Cancer

Cited by 49 publications

References 25 publications

Sex-related differences in clinicopathological features and survival of patients with primary urethral carcinoma: a population-based study

Sex-related differences in clinicopathological features and survival of patients with primary urethral carcinoma: a population-based study

Primary urethral carcinoma – unexpected cause of urethral stricture. Case report and review of the literature.

Primary urethral cancer: treatment patterns and associated outcomes

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