Outcomes and Treatment of Chronic Methicillin-ResistantStaphylococcus aureusDiffers by Staphylococcal Cassette Chromosomemec(SCCmec) Type in Children With Cystic Fibrosis

Heltshe, Sonya L.; Saiman, Lisa; Popowitch, Elena B.; Miller, Melissa B.; Kloster, Margaret; Thompson, Valeria; Ferkol, Thomas; Hoover, Wynton; Schechter, Michael S.; Muhlebach, Marianne S.

doi:10.1093/jpids/piu048

Cited by 17 publications

(14 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a single-center study, we reported that children and adults with CF infected with SCCmec II strains were older, had longer duration of MRSA infection, and were more frequently coinfected with Pseudomonas aeruginosa when compared with patients infected with SCCmec IV strains expressing PVL (24). In addition, in a multicenter study, we showed that pediatric patients with CF chronically infected with SCCmec II strains had a higher rate of treatment with oral antibiotics for protocol-defined pulmonary exacerbations than those with SCCmec IV strains (25). Thus, SCCmec type appears to be associated with different clinical outcomes in patients with CF.…”

mentioning

confidence: 82%

Multicenter Observational Study on Factors and Outcomes Associated with Various Methicillin-Resistant Staphylococcus aureus Types in Children with Cystic Fibrosis

Muhlebach¹,

Heltshe

Popowitch

et al. 2015

Annals ATS

Self Cite

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 82%

Multicenter Observational Study on Factors and Outcomes Associated with Various Methicillin-Resistant Staphylococcus aureus Types in Children with Cystic Fibrosis

Muhlebach¹,

Heltshe

Popowitch

et al. 2015

Annals ATS

Self Cite

View full text Add to dashboard Cite

show abstract

“…In CF, traditionally, two‐thirds of MRSA infections were HA‐MRSA (SCC mec II) strains and one‐third CA‐MRSA, that is, SCC mec IV strains; however, SCCmec IV has been increasing in more recent years . A study evaluating pediatric patients with chronic MRSA infection showed that those with SCCmec II isolates required more frequent antibiotics for pulmonary exacerbations without differences in rate of FEV 1 decline …”

Section: Epidemiologymentioning

confidence: 99%

“…46 A study evaluating pediatric patients with chronic MRSA infection showed that those with SCCmec II isolates required more frequent antibiotics for pulmonary exacerbations without differences in rate of FEV 1 decline. 47 Prevalence of MRSA positive cultures in people with CF increased about fivefold between 2000 and 2014. 48 This increase reflects the trend in the general population.…”

Section: Epidemiologymentioning

confidence: 99%

Biology and management of methicillin resistantStaphylococcus aureusin cystic fibrosis

Akil

Muhlebach

2018

Pediatric Pulmonology

Self Cite

View full text Add to dashboard Cite

Staphylococcus aureus is one of the earliest bacteria isolated from the respiratory tract in people with cystic fibrosis (CF). Its methicillin resistant form, MRSA, has gained attention due to the rapid increase in the last decades and worse outcomes with chronic infection. In the United States, prevalence of MRSA in CF is around 27%, but is much lower (3-18%) in most other countries. Methicillin is typically genetically encoded by the mecA gene, which encodes for an alternative penicillin binding protein (PRBa). This PRBa has low affinity to β-lactams, thereby enabling growth of S. aureus in the presence of penicillinase resistant penicillins and most other β-lactams. Non-mecA positive strains of MRSA, so-called borderline resistant (BORSA) have also been described. In addition to production of toxins, the virulence of S. aureus is conferred by its adaptability allowing persistence in face of antibiotic therapies and host defense. These adaptive growth mechanisms include small colony variants, biofilms, and growth under anaerobic conditions. Several reports have described successful eradication of MRSA, yet only two randomized trials of eradication during early infection have been conducted. A list of MRSA specific antibiotics with dosing relevant to CF patients is presented here. Many of these require special dosing in people with CF. Novel antibiotics are in trials for skin and soft tissue infections and it is unclear if and when those might be available for lung infections. Thus the best strategies for MRSA would be primary prevention.

show abstract

“…As the first identified type, type I SCCmec was nonpredominant in the 1970s, which was reported in a limited number of areas, including Brazil, Iran, Japan, Philippines, Spain, Switzerland, and the United States [202][203][204][205][206][207][208][209][210]. Type II SCCmec had been commonly found in Japan, Korea (occasionally in China), and the United States [206,207,[211][212][213][214][215] and occasionally detected in Algeria, Brazil, China, Iran, Turkey, and Thailand [205,[216][217][218][219][220][221]. Type III SCCmec has been most frequently found among HA-MRSA and remains the predominant type in many countries or areas including Asia (China, Hong Kong, Iran, Malaysia, Singapore, Taiwan, and Thailand), Europe (Poland, Portugal, and Turkey), and South America (Brazil) [205, 208-214, 217, 220, 222-231].…”

Section: Prevalence and Occurrencementioning

confidence: 99%

Staphylococcal Food Poisoning and Novel Perspectives in Food Safety

Xu¹,

Peters²,

Li³

et al. 2016

Significance, Prevention and Control of Food Related Diseases

View full text Add to dashboard Cite

Ingestion of food is the major way for human beings to obtain nutrient substances for basic living, and therefore, the quality and safety of food is a major concern. Foodborne illness includes any illness resulting from the consumption of contaminated food that contains pathogenic bacteria, viruses, or chemical or natural toxins. Consequently, food safety is considered to be a globally expanding issue and thus a leading topic in public health, no longer limited to foodborne illnesses but extended to nearly every safety issue regarding "farm to table" food approaches. Bacterial foodborne infections occur by ingestion of food contaminated with growth of pathogenic bacteria, toxin production, and continuous bacterial growth in intestines. In the past decade, a large number of cases or reports have been available on food containing unhealthy, harmful, or toxic substances (other than food poisoning outbreaks) worldwide. Foodborne microorganisms, primarily associated with pathogenic bacteria and toxic substances produced in food, have presented major challenges for food safety. As a global foodborne pathogen, Staphylococcus aureus is typically capable of causing a large number of infections, including food poisoning. Thus, this chapter aims to review several factors contributing to the rise of staphylococci as a growing concern for the food safety industry, including the growth of S. aureus, production and regulation of staphylococcal enterotoxins, the viable putative but nonculturable (VPNC) state, and antimicrobial resistance of Staphylococcus caused by the indiscriminate use of antibiotics in both clinical and veterinary settings.

show abstract

Outcomes and Treatment of Chronic Methicillin-ResistantStaphylococcus aureusDiffers by Staphylococcal Cassette Chromosomemec(SCCmec) Type in Children With Cystic Fibrosis

Cited by 17 publications

References 39 publications

Multicenter Observational Study on Factors and Outcomes Associated with Various Methicillin-Resistant Staphylococcus aureus Types in Children with Cystic Fibrosis

Multicenter Observational Study on Factors and Outcomes Associated with Various Methicillin-Resistant Staphylococcus aureus Types in Children with Cystic Fibrosis

Biology and management of methicillin resistantStaphylococcus aureusin cystic fibrosis

Staphylococcal Food Poisoning and Novel Perspectives in Food Safety

Contact Info

Product

Resources

About