Outcomes following embolization in patients with cardiac myxoma

Boyacıoğlu, Kamil; Kalender, Mehmet; Dönmez, Arzu Antal; Çayhan, Burçin; Tunçer, Mehmet Altuğ

doi:10.1111/jocs.13220

Cited by 13 publications

(15 citation statements)

References 23 publications

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“…[3][4][5][6] Systemic embolization occurs in approximately 30-40% of patients with cardiac myxoma. 7,8 As 75-80% of the tumors arise in the left atrium, approximately half of the embolic events may affect the central nervous system (CNS). 9 The neurological manifestation of cerebral embolization depends on whether embolic tumor cells remain intraluminal, leading to ischemic stroke, invade the vessel wall, resulting in intracranial aneurysms, or, in rare circumstances, transgress the vessel wall, leading to brain parenchymal seeding.…”

Section: Introductionmentioning

confidence: 99%

Cerebral embolization associated with parenchymal seeding of the left atrial myxoma: Potential role of interleukin‐6 and matrix metalloproteinases

et al. 2020

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Systemic embolization has been reported in up to 40% of patients with left atrial myxoma, half of them with cerebral involvement. However, development of intracerebral embolization associated with parenchymal seeding of the myxoma emboli is an extremely rare complication, with only 36 histologically diagnosed cases reported in the published literature. We describe a 69-year-old woman who arrived at the emergency service with hemiparesis associated with drug-resistant epilepsy and a medical history of resection of a left atrial myxoma 10 months previously. Cranial computed tomography revealed multiple large lesions of heterogeneous density and cystic components in the occipital lobes and posterior fossa parenchyma. Histopathological analyses after stereotactic biopsy of the occipital lesion revealed infiltrative myxoma cells with benign histological findings and uniform expression of calretinin similar to that of the primary cardiac myxoma. Additional immunohistochemical studies confirmed brain parenchymal seeding of the myxoma cells with strong expression of interleukin-6 (IL-6) and focal expression of matrix metalloproteinases-2 (MMP-2). Here, we discuss the clinicopathological features of intracerebral embolization of left atrial myxomas associated with progressive parenchymal seeding of the tumor emboli and the potential pathogenic role of IL-6 and MMPs.

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Section: Introductionmentioning

confidence: 99%

Cerebral embolization associated with parenchymal seeding of the left atrial myxoma: Potential role of interleukin‐6 and matrix metalloproteinases

et al. 2020

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“…Emboli can also be composed of thrombotic material covered with tumor cells. 12,13 Myxomas with an irregular tumor surface, tumor location, are more frequently associated with production of emboli. 13,14 There is no consensus regarding whether or not tumor size is related to the likelihood of a stroke.…”

Section: Discussionmentioning

confidence: 99%

Characterizations of Ischemic Stroke Complications in Cardiac Myxoma Patients at a Single Institution in Eastern China

Zhang

et al. 2021

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“…Embolization rates of patients with both the right and left cardiac myxomas vary between 25.3% [8] and 43% [9]. Studies have shown that morphology of cardiac myxoma is the most predictive factor of embolic events.…”

Section: Discussionmentioning

confidence: 99%

Rare Association between Giant Right Ventricular Myxoma and Right Coronary Artery Tumour Blush with Complicating Pulmonary Tumour Embolism

Goh¹,

Mehrotra

Buchholz³

et al. 2019

Case Reports in Cardiology

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Cardiac myxoma is a benign primary cardiac tumour which can present with nonspecific symptoms of right heart failure, syncope, exertional dyspnea, and pulmonary embolism. We describe a case of a right ventricular myxoma complicated with bilateral pulmonary embolism, with an incidental right coronary artery fistula but otherwise normal coronary anatomy on coronary angiogram. This case report emphasizes the importance of performing a transesophageal echo in the setting of pulmonary embolism to search for the origin of thrombus/tumour, and performing a comprehensive assessment is also necessary to rule out coronary artery disease, coronary artery fistula that may also represent a tumour blush.

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Outcomes following embolization in patients with cardiac myxoma

Cited by 13 publications

References 23 publications

Cerebral embolization associated with parenchymal seeding of the left atrial myxoma: Potential role of interleukin‐6 and matrix metalloproteinases

Cerebral embolization associated with parenchymal seeding of the left atrial myxoma: Potential role of interleukin‐6 and matrix metalloproteinases

Characterizations of Ischemic Stroke Complications in Cardiac Myxoma Patients at a Single Institution in Eastern China

Rare Association between Giant Right Ventricular Myxoma and Right Coronary Artery Tumour Blush with Complicating Pulmonary Tumour Embolism

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