Background
We evaluated clinical and functional outcomes following salvage total laryngectomy (STL).
Methods
Retrospective review of 218 patients who underwent STL between 1994 and 2014.
Results
Seventy percent of patients originally had T1–2, N0 tumors and 73% had definitive external beam radiation therapy (EBRT) alone. A majority utilized TEP (77%) and were gastrostomy free (80%) at last follow up. The 5-year disease control and overall survival rates were 65% and 57%. Patients with disease-free interval (DFI) following initial treatment < 2 years were more likely to develop recurrence (p=0.001) and die of disease (p=0.032) following STL. DFI following EBRT impacted disease control (p<0.001), with 5-year disease control of 92% for >5 year DFI and 60% for <2 year DFI.
Conclusion
Most patients remain disease-free following STL, achieve intelligible tracheo-esophageal speech and maintain an oral diet. Delayed recurrence following initial treatment portends better survival and may indicate a distinct biological profile.