Outcomes From Polyhydramnios With Normal Ultrasound

Yefet, Enav; Daniel-Spiegel, Etty

doi:10.1542/peds.2015-1948

Cited by 33 publications

(39 citation statements)

References 26 publications

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“…In comparison with other studies [12,13] we observed fewer cases of diabetes in patients with polyhydramnios, most of them in the group with moderate polyhydramnios and only one in women with severe one. This result might be explained by better metabolic control in our diabetic group.…”

Section: Discussioncontrasting

confidence: 82%

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Polyhydramnios — frequency of congenital anomalies in relation to the value of the amniotic fluid index

Kornacki

Adamczyk²,

Wirstlein³

et al. 2017

Ginekol Pol

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Objectives: The aims of our study were to assess the correlation between the amniotic fluid index (AFI) value and the frequency and type of fetal anomalies. Material and methods:The material included 94 patients at the third trimester of pregnancy, 60 with mild polyhydramnios, 19 with moderate one, and 15 with severe one. Polyhydramnios was diagnosed if AFI was > 24 cm. All patients were divided into three groups based on the value of AFI: 1) mild polyhydramnios with AFI between 24.1 and 29.9 cm, 2) moderate polyhydramnios with AFI between 30-34.9 cm, and 3) severe polyhydramnios with AFI ≥ 35 cm. Results:The incidence of fetal malformations correlated significantly with the degree of polyhydramnios and was the highest in patients with severe polyhydramnios (53.3%, p = 0.002). Congenital malformations of the gastrointestinal tract were the most frequent fetal anomalies in the whole group of patients (5.3%). Trisomy 18 was the most frequent aneuploidy found in women with polyhydramnios (2.1%). Conclusions:1. The incidence of fetal congenital anomalies significantly increases with the degree of polyhydramnios, being most frequent in severe one and rather rare in a mild one. 2. Congenital malformations of the gastrointestinal tract were the most frequent anomalies in patients with polyhydramnios, especially in women with severe polyhydramnios.

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Section: Discussioncontrasting

confidence: 82%

“…This result might be explained by better metabolic control in our diabetic group. Although the incidence of diabetes was approximately 10% in patients with polyhydramnios, it was approximately 20.9% and 14.9%, respectively, as observed by Yefet et al [13] and Boito et al [12].…”

Section: Discussionmentioning

confidence: 64%

Polyhydramnios — frequency of congenital anomalies in relation to the value of the amniotic fluid index

Kornacki

Adamczyk²,

Wirstlein³

et al. 2017

Ginekol Pol

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“…At the beginning, we would like to answer the question: does the normal weight of the child or its disorders, such as SGA or macrosomia accompanying idiopathic polyhydramnios may be a prognostic factor of abnormalities after delivery? The percentage of fetuses with macrosomia in our study was 12.5% (8/64) and was similar to the results obtained by Yefet [8]. Yefet showed a statistically significant relationship between fetal macrosomia and idiopathic polyhydramnios, and compared the outcome to the control group without polyhydramnios (11% vs. 5%).…”

Section: Discussionsupporting

confidence: 90%

“…The percentage of genetic defects estimated in our study was 3.1%. This result is similar to the outcomes obtained by Yefet et al (3.7%) and the meta-analysis published in 2015 [8,11]. On the basis of the analysis of 1729 pregnancies with polyhydramnios of the unknown etiology, Sagi-Dain estimated the risk of chromosomal aberration at 2.8 ± 3.7%.…”

Section: Discussionsupporting

confidence: 89%

Follow-up of children with antenatally diagnosed idiopathic polyhydramnios

et al. 2019

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Objectives: The aim of our work was to assess the development of children with antenatally diagnosed idiopathic polyhydramnios, over 12 months from the end of pregnancy. Material and methods: The study included 91 healthy pregnant patients with idiopathic polyhydramnios. Diagnostic tests results and perinatal medical history were obtained retrospectively. Parents of children were contacted by phone and by mail. The answers were obtained from 64 (70%) parents. For statistical analysis SigmaStat3.5 software was used. Results: Ninety six percent of parents declared that in their opinion the development of children was normal. Abnormalities were found in 44% of the children. Thirty percent of neonates demonstrated mild abnormalities which may be due to organic or functional neuromuscular disorders: abnormal muscle tone, speech apparatus and development disorders, swallowing and breathing problems (manifested as vomiting, excessive regurgitation, idiopathic apnoeas). Isolated small malformations were diagnosed in 12 (19%) children. Two children (3%) with SGA were diagnosed with genetic syndromes. More than one of the abnormalities described above were diagnosed in 14% of children. Gestational age at the time of polyhydramnios diagnosis and its severity were not prognostic factors for abnormalities. Seventy percent of newborns were male. Conclusions: Despite the subjectively positive assessment of the development of children by the majority of parents, groups of common disorders requiring long-term follow-up have been identified. Functional disorders of the gastrointestinal tract, CNS and the group of neuromuscular disorders may be responsible for idiopathic polyhydramnios. SGA with co-existing idiopathic polyhydramnios is associated with the risk of genetic diseases. The more frequent incidence of idiopathic polyhydramnios in male fetuses requires further research.

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“…Up to 2% of all pregnancies have an excess amount of fluid meeting the criteria for polyhydramnios[1,2]. It is reported in the literature that approximately sixty percent of polyhydramnios is idiopathic; twenty percent of polyhydramnios can be attributed to poorly controlled or undiagnosed diabetes and the remainder of cases of polyhydramnios are associated with fetal anomalies[2-4]. Several adverse outcomes have been associated with polyhydramnios including preterm labor and rupture of membranes.…”

Section: Introductionmentioning

confidence: 99%

Amount of polyhydramnios attributable to diabetes may be less than previously reported

Moore

2017

WJD

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AIMTo evaluate the frequency and the quantity of polyhydramnios attributable to diabetes in pregnancy.METHODSThe charts of patients with a four-quadrant amniotic fluid index (AFI) ≥ 20 cm and either a diagnosis of diabetes or a diabetes screening test during the index pregnancy were retrospectively reviewed. AFI was stratified into 5 categories and the frequency of diabetes was evaluated for each group. The frequency of polyhydramnios attributable to diabetes was compared to the frequency of polyhydramnios in the setting of fetal anomalies or no known cause.RESULTSOne thousand five hundred and forty-five patients were included in the study. Eight point five percent (n = 131) had diabetes and no other cause for polyhydramnios. Eleven point two percent (173) had antenatally diagnosed anomalies. For all categories of AFI except the largest (> 40.9 cm) the most common cause of polyhydramnios was idiopathic. In patients with diabetes the AFI was most likely to be between 26 cm and 35.9 cm.CONCLUSIONThe rate of polyhydramnios in this study is 8.5%. Patients with diabetes most commonly have mild polyhydramnios between 26 and 35.9 cm of fluid on a four-quadrant AFI.

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Outcomes From Polyhydramnios With Normal Ultrasound

Cited by 33 publications

References 26 publications

Polyhydramnios — frequency of congenital anomalies in relation to the value of the amniotic fluid index

Polyhydramnios — frequency of congenital anomalies in relation to the value of the amniotic fluid index

Follow-up of children with antenatally diagnosed idiopathic polyhydramnios

Amount of polyhydramnios attributable to diabetes may be less than previously reported

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