Outcomes in 140 critically ill patients with status epilepticus

Legriel, Stéphane; Mourvillier, Bruno; Bele, Nicolas; Amaro, J.; Fouet, P; Manet, P.; Hilpert, F

doi:10.1007/s00134-007-0944-0

Cited by 25 publications

(36 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We studied patients at particularly high risk for NCSE, namely, comatose survivors of cardiac arrest; comatose patients with no further clinical seizures after treatment for convulsive status epilepticus; and various conditions associated with coma such as stroke, prolonged hypoglycemia, bacterial meningitis, prolonged hypoxemia, and traumatic brain injury. The 26.3% prevalence of NCSE diagnosed using EEG in our population reflects this high level of risk, which allowed us to evaluate a pragmatic strategy for NCSE detection in comatose ICU patients 3,5,7,27,28 . Lower prevalences were found in retrospective studies of unselected comatose patients.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Assessment of cerebral blood flow changes in nonconvulsive status epilepticus in comatose patients: A pathophysiological transcranial Doppler study

Merceron

Geeraerts

Montlahuc³

et al. 2014

Seizure

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 94%

“…NCSE is a severe complication associated with high morbidity and mortality rates and must therefore be diagnosed promptly. 3,[5][6][7] EEG monitoring is the reference standard for diagnosing NCSE. However, EEG changes related to NCSE may be difficult to differentiate from those produced by other causes of coma, such as encephalopathy.…”

Section: Introductionmentioning

confidence: 99%

Assessment of cerebral blood flow changes in nonconvulsive status epilepticus in comatose patients: A pathophysiological transcranial Doppler study

Merceron

Geeraerts

Montlahuc³

et al. 2014

Seizure

Self Cite

View full text Add to dashboard Cite

show abstract

“…Metabolic disorder means an abnormality of blood components such as sodium, calcium, urea, or glucose, etc. Encephalopathy indicates post-cardiac arrest patients with hypoxic ischemic encephalopathy diagnosed by computed tomography of the brain (Legriel et al, 2008).…”

Section: Causes Of Seizuresmentioning

confidence: 99%

Intravenous levetiracetam of hospitalized patients in Srinagarind Hospital

Tiamkao¹,

Thongplew²,

Chawsamtong³

et al. 2013

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Levetiracetam (LEV) is a fairly new antiepileptic drug with broad effectiveness in controlling seizures.Presently, there is limited clinical data worldwide. This study aims to add more clinical efficacy and safety data for intravenous LEV. Chart review was done in patients who received intravenous LEV at Srinagarind Hospital, Khon Kaen University, Thailand from August, 2010 to June, 2012. There were 48 prescriptions on 46 patients with a mean age of 56.75 years. The three most common causes of seizures were metabolic derangement, renal dysfunction, and hypoxic ischemic encephalopathy. Intravenous LEV was used for status epilepticus (SE) for 34 out of 48 prescriptions (70.8%) and non-SE 14 times (29.2%). The loading and maintenance doses of intravenous LEV were 1520.60 mg (range 1000 to 6500) and 1171.70 mg/day (500 to 3000). Seizure was controlled by intravenous LEV in 21 out of 34 prescriptions with SE (61.8%) and all patients with non-SE (100%). The overall mortality rate was 45.7% (21 out of 46 patients). The most common cause of death was sepsis with multiple organ failure (17 out of 21 patients or 81%). There was no obvious side effect of intravenous LEV in any patient. Intravenous LEV is effective and safe in seizure control particularly in patients with renal and liver dysfunction who had either SE or non-SE.

show abstract

“…Besides short term mortality rates there is increasing evidence for long term complications which hamper prognoses after treatment of GCSE [5,15,17]. Several studies have aimed to identify risk factors in order to tailor therapeutic measures early and recently a risk score was suggested [63].…”

Section: Prognosismentioning

confidence: 99%

Status Epilepticus

Hagemann¹

2011

TOCCMJ

View full text Add to dashboard Cite

Generalized convulsive status epilepticus (GCSE) is a neurological emergency with high mortality which needs immediate recognition and treatment. There is a variety of different categories of status epilepticus (SE) and the form and aetiology of status are important predictors for prognosis. As early treatment is beneficial out-of-hospital treatment can be advised. The first-line treatment of GCSE is lorazepam which can be followed by phenytoin and induction of coma by anaesthetics. Because of receptor changes short-term prognosis to stop seizures becomes worse with time and the longterm prognosis is worst in case of refractory SE. Non convulsive forms of SE can only be diagnosed with an EEG and should be treated more cautiously to prevent potentially harmful adverse events of therapy. Some of the modern anticonvulsants which are available for intravenous use may have good efficacy and tolerability but are not licensed for use in SE, yet. Therefore, they should only be used with neurology specialist advise. For all institutions it is advisable to consent on an in-house protocol which all physicians are familiar with. This review gives a pragmatic overview of diagnosis, classification, and treatment of SE.

show abstract

Outcomes in 140 critically ill patients with status epilepticus

Cited by 25 publications

References 0 publications

Assessment of cerebral blood flow changes in nonconvulsive status epilepticus in comatose patients: A pathophysiological transcranial Doppler study

Assessment of cerebral blood flow changes in nonconvulsive status epilepticus in comatose patients: A pathophysiological transcranial Doppler study

Intravenous levetiracetam of hospitalized patients in Srinagarind Hospital

Status Epilepticus

Contact Info

Product

Resources

About