Outcomes in grade 3B follicular lymphoma: an international study led by the Australasian Lymphoma Alliance

Abstract

Grade (G) 3B follicular lymphoma (FL) is a rare FL subtype which exists on a histological continuum between ‘low-grade’ (Grade 1, 2 and 3A FL) and diffuse large B-cell lymphoma (DLBCL) appearing to share features with each. Clinical characteristics and outcomes are poorly understood due to lack of adequate representation in prospective trials and large-scale analyses. We analyzed 157 G3BFL cases from 18 international centers, and two comparator groups; G3AFL (n=302) and DLBCL (n=548). Composite histology with DLBCL or low-grade FL occurred in approximately half of G3BFL cases. With median 5 years follow-up, G3BFL overall (OS; P

Follicular lymphoma grade 3B: low grade, high grade or should we skip the grade?

“…Barraclough and colleagues have now conducted the largest international analysis of G3BFL in the rituximab era, evaluating the outcomes of 157 patients with G3BFL at a median follow-up of 5 years. 4 They included cases of composite G3A/3BFL, pure G3BFL, and G3BFL/DLBCL along with large G3AFL and DLBCL comparator groups. In line with current treatment paradigms, patients with G3BFL received rituximab or obinutuzumab combined with CHOP or CHOP-like chemotherapy.…”