Outcomes in Patients With Chronic Renal Failure on Hemodialysis After Aortic Valve or Root Replacement

Malik, Aroosa; Longi, Faraz; Naeem, Aroma; Clemence, Jr Jeffrey; Makkinejad, Alexander; Norton, Elizabeth L.; Wu, Xiaoting; Patel, Himanshu J.; Deeb, G. Michael; Yang, Bo

doi:10.1053/j.semtcvs.2021.05.019

Cited by 3 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2) Due to the complex pathogenesis of chronic renal failure, western medicine focused on treating the primary disease, avoiding and correcting the risk factors for the progression of chronic renal failure, and preventing and treating complications. 3) With the development of traditional Chinese medicine (TCM), the clinical application of TCM compounds had achieved significant effects in delaying the progression of CRF, improving patients' clinical symptoms, and reducing and slowing down the occurrence of complications. 4) SKI was composed of extracts of Astragalus, Salvia miltiorrhiza, rhubarb and safflower.…”

Section: Introductionmentioning

confidence: 99%

Renal Metabolomics Study and Critical Pathway Validation of Shenkang Injection in the Treatment of Chronic Renal Failure

Zhou,

Wang,

Zhang

et al. 2024

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

To reveal the mechanism of Shenkang injection (SKI) in the treatment of chronic renal failure, and verify the key pathway. In this work, an untargeted metabolomics approach was performed by LC-MS coupled with multivariate statistical analysis to provide new insights into therapeutic mechanism of SKI. Hematoxylin-eosin (H&E) Staining and Immunohistochemistry were used to evaluate the effects of drug treatment, Western blot was used to verify the critical pathway. Then, a total of 44 potential biomarkers of chronic renal failure (CRF) were identified and reversed regulation, including 2,8-dihydroxypurine, 5-methoxytryptophan, uric acid, acetylcarnitine, taurine, etc. Mainly concerned with arginine and proline metabolism, purine metabolism, histidine metabolism, etc. Pathological examination showed that the renal interstitium of SKI group was significantly improved, with fewer inflammatory cells and thinner vascular walls compared with the model group. Immunohistochemical results showed that the expression of α-smooth muscle actin (α-SMA) was decreased, and the expression of E-cadherin was increased in CRF model group, and the two indicators were reversed regulation in SKI injection, indicating that the degree of fibrosis was relieved. Critical signaling pathway phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) and nuclear factor-kappaB (NF-κB) protein expressions were significantly inhibited. This study was the first to employ metabolomics to elucidate the underlying mechanisms of SKI in chronic renal failure. The results would provide some support for clinical application of traditional Chinese medicines in clinic.

show abstract

Section: Introductionmentioning

confidence: 99%