Outcomes in patients with marginal zone lymphomas undergoing transformation to high-grade lymphomas.

Alderuccio, Juan Pablo; Desai, Amrita J.; Crestani, Nicolas Gallastegui; Ramdial, Jeremy; Kimble, Erik; Fuente, Macarena I. de la; Chapman, Jennifer R.; Vega, Francisco; Zhao, Wei; Reis, Isildinha M.

doi:10.1200/jco.2018.36.15_suppl.7559

Cited by 2 publications

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“…Histologic transformation is reported in 3–15% of patients with nodal MZL and is often associated with a poor outcome . In a large retrospective series, the crude incidence of histologic transformation was 34/453 (7.5%) with elevated serum LDH, >4 nodal sites and failure to achieve CR associated with increased risk of transformation by multivariable competing risk regression analysis . While there is an association with hepatitis C infection (Table ), a history of autoimmunity is less common than with other forms of MZL…”

Section: Marginal Zone Lymphomamentioning

confidence: 99%

Front‐line management of indolent non‐Hodgkin lymphoma in Australia. Part 2: mantle cell lymphoma and marginal zone lymphoma

Cheah

Opat

Trotman

et al. 2019

Internal Medicine Journal

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Mantle cell lymphoma (MCL) and the marginal zone lymphoma (MZL) subtypes (nodal MZL, extra-nodal MZL of mucosa-associated lymphoid tissue (MALT lymphoma) and splenic MZL) are uncommon lymphoma subtypes, accounting for less than 5-10% of all non-Hodgkin lymphoma. The evidence base for therapy is therefore limited and enrolment into clinical trials is preferred. Outcomes for patients with MCL have been steadily improving mainly due to the adoption of more intense strategies in younger patients, the use of rituximab maintenance and the recent introduction of bendamustine in older patients. MZL is a more heterogeneous group of cancer with both nodal, extra-nodal and splenic subtypes. Extranodal MZL may be associated with autoimmune or infectious aetiologies, and can respond to eradication of the causative pathogen. Proton pump inhibitor plus dual antibiotics in Helicobacter pylori positive gastric MALT lymphoma is curative in many patients. Watchful waiting is appropriate in most patients with asymptomatic advanced stage disease, which tends to behave in a particularly indolent manner. Other options for symptomatic disease include splenectomy, chemoimmunotherapy with rituximab and, more recently, targeted therapies.

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Section: Marginal Zone Lymphomamentioning

confidence: 99%

Front‐line management of indolent non‐Hodgkin lymphoma in Australia. Part 2: mantle cell lymphoma and marginal zone lymphoma

Cheah

Opat

Trotman

et al. 2019

Internal Medicine Journal

View full text Add to dashboard Cite

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Clinicopathological characteristics and genomic profiling in patients with transformed lymphoma: a monocentric retrospective study

Zhao,

Bian,

Hao

et al. 2024

Annals of Medicine

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Background Transformed lymphoma occurs when indolent lymphoma transforms into more aggressive lymphoma usually associated with poor prognosis. Methods In this study, we analysed the immunophenotypes, prognostic factors and outcomes of 35 patients with transformed lymphoma from among 306 marginal zone lymphoma (MZL), 544 follicular lymphoma (FL) and 871 chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) cases. In addition, we performed whole-exome sequencing study of seven transformed MZL (tMZL) cases. Results Our results demonstrate that the median time from indolent lymphoma diagnosis to transformed DLBCL was 35 months (range, 14–53 months). The 5-year overall survival (OS) and progression-free survival (PFS) rates after histological transformation (HT) were 50% and 26%, respectively. Kaplan–Meier survival analysis revealed that asynchronous HT and transformed CLL/SLL (tCLL/SLL) were significant adverse prognostic factors for OS after DLBCL HT. We identified mutations involvement in chromatin remodelling ( CREBBP and EP300 ) and regulators of NF-κB signalling ( TNFAIP3, BCL10, MYD88, CD79B and CARD11 ) were affected in tMZL. Conclusion Whole-exome sequencing and copy-number analysis revealed that tMZL derives from the divergent evolution of an ancestral common progenitor clone (CPC). Collectively, this study provides clinicopathological characteristics of three common types of transformed lymphomas and the genetic profile of tMZL with diagnostic and therapeutic implications.

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Outcomes in patients with marginal zone lymphomas undergoing transformation to high-grade lymphomas.

Cited by 2 publications

References 0 publications

Front‐line management of indolent non‐Hodgkin lymphoma in Australia. Part 2: mantle cell lymphoma and marginal zone lymphoma

Front‐line management of indolent non‐Hodgkin lymphoma in Australia. Part 2: mantle cell lymphoma and marginal zone lymphoma

Clinicopathological characteristics and genomic profiling in patients with transformed lymphoma: a monocentric retrospective study

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