Outcomes in patients with over 1-year follow-up after peroral endoscopic myotomy (POEM)

Ward, Marc A.; Gitelis, Matthew E.; Patel, Lava; Vigneswaran, Yalini; Carbray, JoAnn; Ujiki, Michael

doi:10.1007/s00464-016-5130-4

Cited by 28 publications

(32 citation statements)

References 29 publications

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“…Among the six studies mentioned the SF-36 scale, four articles reported that several domains of the eight domains did not demonstrate any significant differences in scores. 10,12,16,17) But Liu et al and Perbtani et al reported the each domain of SF-36 was significantly improved. 11,18) We guess that the reason may be due to the small sample size in these four studies.…”

Section: Discussionmentioning

confidence: 97%

“…Most of the study we included used the SF-36 to evaluate the improvement of QoL. 8,11,12,[16][17][18] The SF-36 was a multi-purpose, short-form health survey which contains 36 questions. And it yielded an eight-scale profile (PF, RP, BP, GH, SF, VT, RE, and MH) of scores as well as PCS and MCS.…”

Section: Discussionmentioning

confidence: 99%

“…Supplementary Table 2 shows the quality assessment of each study according to using NIH quality assessment tool. Out of 12 involved studies, seven studies 11,12,[14][15][16][17][18] were of good quality and the remaining five studies [7][8][9][10]13) were of fair quality.…”

Section: Publication Bias and Quality Of Included Studiesmentioning

confidence: 99%

“…Previous publications have proved the excellent efficacy and safety of POEM, and even shown this novel endoscopic intervention could improve patients' life quality. [6][7][8][9][10][11][12][13][14][15][16][17][18] QoL is a multidimensional construct that is affected by physical health, psychological health, functional status, and social circumstances which may be classified as disease specific or generic. 19) There is a growing number of people who thought that QoL after procedure was as important as overall survival.…”

Section: Introductionmentioning

confidence: 99%

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Quality of Life Following Peroral Endoscopic Myotomy for Esophageal Achalasia: A Systematic Review and Meta-Analysis

Zhong

Tan

Ren

et al. 2020

ATCS

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Background: Peroral endoscopic myotomy (POEM) is a novel minimally invasive intervention for treating esophageal achalasia. Previous publications have proved its excellent efficacy and safety, and even shown it could improve patients' quality of life (QoL). So, we conducted this study to explore the changes of QoL following POEM. Methods: A comprehensive literature search was conducted on PubMed, EMBASE, and Cochrane Library covering the period from January 2009 to April 2019. The statistical analysis was carried out using Review Manager 5.3. Results: A total of 12 studies including 549 patients were identified, which assessed the QoL using validated questionnaires administered. After POEM, the SF-36 questionnaire score of each domain (physical function, role physical function, body pain, general health (GH), social function, vitality, emotional role function, mental health) was significantly increased (p < 0.05). Meanwhile, mental component scale (MCS) and physical component scale (PCS) scores were all improved in patients after POEM procedure (MCS : 12.11, 95% confidence interval [CI], 4.67-19.55, p = 0.001, I 2 = 88%, PCS: 17.01, 95% CI, 2.91-31.11, p = 0.02, I 2 = 97%). The gastroesophageal reflux disease health-related quality of life questionnaires (GERD-HRQL) also decreased significantly after POEM (13.01, 95% CI, 9.98-16.03, p < 0.00001, I 2 = 30%). Conclusions: Our current evidence suggests there is significant improvement in QoL after POEM procedure.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Publication Bias and Quality Of Included Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quality of Life Following Peroral Endoscopic Myotomy for Esophageal Achalasia: A Systematic Review and Meta-Analysis

Zhong

Tan

Ren

et al. 2020

ATCS

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“…Two studies (17,18) were published by the same group on a similar patient population, however, the outcomes analyzed in each study were different and thus they were included in this analysis. Ujiki et al (19) and Ward et al (20) are from the same group, but the publications (completed in 2013 and 2017) consisted of a heterogeneous group of patients and had different results, thus both studies were used in this analysis. There were 893 patients overall; 359 in POEM group and 534 in LHM.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Peroral (Poem) or Surgical Myotomy for the Treatment of Achalasia: A Systematic Review and Meta-Analysis

Martins

Ribeiro

Moura

et al. 2020

Arq. Gastroenterol.

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BACKGROUND: Achalasia is a neurodegenerative motility esophageal disorder characterized by failure of lower esophageal sphincter relaxation. The conventional treatment option for achalasia has been laparoscopic Heller myotomy (LHM). However, in 2010, Inoue et al. described peroral endoscopic myotomy (POEM), a minimally invasive procedure, as an alternative therapy. To date, some studies with small sample sizes have aimed to compare outcomes of LHM vs POEM. OBJECTIVE: Thus, the aim of this study is to perform a systematic review and meta-analysis to better evaluate the efficacy and safety of these two techniques. METHODS: Individualized search strategies were developed from inception through April 2019 in accordance with PRISMA guidelines. Variables analyzed included operative time, overall adverse events rate, post-procedure gastroesophageal reflux disease (GERD), hospitalization length, post-procedure pain score, and Eckardt Score reduction. RESULTS: Twelve cohort trials were selected, consisting of 893 patients (359 in POEM group and 534 in LHM.) No randomized clinical trials were available. There was no difference in operative time (MD= -10,26, 95% CI (-5,6 to 8,2), P<0.001) or Post-Operative Gastroesophageal Reflux (RD: -0.00, 95%CI: (-0.09, 0.09), I2: 0%). There was decreased length of hospital stay for POEM (MD: -0.6, 95% CI (-1.11, -0.09), P=0.02), and an increased mean reduction in Eckardt score in POEM patients (MD = -0.257, 95% CI: (-0.512 to -0.002), P=0.048), with similar rates of adverse events. CONCLUSION: POEM demonstrated similar results compared to laparoscopic Heller myotomy with regards to improvement of dysphagia, post-procedure reflux, and surgical time, with the benefit of shorter length of hospital stay. Therefore, POEM can be considered an option for patients with achalasia.

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Per-oral Endoscopic Myotomy

Holmstrom¹,

Hungness²

2019

Foregut Surgery

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Outcomes in patients with over 1-year follow-up after peroral endoscopic myotomy (POEM)

Cited by 28 publications

References 29 publications

Quality of Life Following Peroral Endoscopic Myotomy for Esophageal Achalasia: A Systematic Review and Meta-Analysis

Quality of Life Following Peroral Endoscopic Myotomy for Esophageal Achalasia: A Systematic Review and Meta-Analysis

Peroral (Poem) or Surgical Myotomy for the Treatment of Achalasia: A Systematic Review and Meta-Analysis

Per-oral Endoscopic Myotomy

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