Outcomes in recent‐onset inflammatory polyarthritis differ according to initial titers, persistence over time, and specificity of the autoantibodies

Guzian, Marie-Caroline; Carrier, Nathalie; Cossette, Pierre; Brum‐Fernandes, Artur J. de; Liang, Patrick; Ménard, Henri-André; Boire, Gilles

doi:10.1002/acr.20288

Cited by 28 publications

(27 citation statements)

References 40 publications

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“…One would reason that younger individuals may initially react more intensely to pain and loss of function (6), but that later on, other individual variables (such as coping or depression) would matter more. This is noteworthy, since we previously observed that increasing age positively correlated with radiologic and functional severity in patients with EIP (16,33).…”

Section: Discussionmentioning

confidence: 59%

Predictors of Pain for Patients With Early Inflammatory Polyarthritis

Dobkin

Liu

Abrahamowicz

et al. 2013

Arthritis Care & Research

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Objective. To identify predictors of pain at 1 year in patients with early inflammatory polyarthritis (EIP).Methods. Using a prospective design, patients were examined by a rheumatologist and completed questionnaires at baseline and at 1 year after symptom onset. Separate regression analyses were run for pain intensity, sensory pain, and affective pain. Age and sex were adjusted in cross-sectional and longitudinal analyses; baseline potential predictors consisted of measures for corresponding pain values and disease activity, depression, coping scores, medication use, rheumatoid arthritis criteria being met, and duration of symptoms. Results. A total of 211 patients were enrolled in the study (mean ؎ SD age 58.8 ؎ 14.2 years, 63% women). There were significant improvements at 1 year for disease activity, instrumental coping, emotional coping, depression, and all 3 pain measures. At baseline, disease activity and depression were positively associated with all types of pain; in addition, instrumental coping was positively associated with sensory pain and palliative coping was positively associated with affective pain. At 1 year, pain intensity was predicted by baseline pain intensity, duration of symptoms, use of disease-modifying antirheumatic drugs (DMARDs), and emotional coping. Sensory pain was predicted by baseline sensory pain and DMARD use. Affective pain was predicted by baseline affective pain, DMARD use, and emotional coping. Conclusion. The majority of treated EIP patients can expect improvements in clinical and psychosocial variables over the first year of their illness. Emotional coping at baseline may contribute to pain in the future, and therefore it may be useful for patients to learn other means of dealing with this chronic disease.

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Section: Discussionmentioning

confidence: 59%

Predictors of Pain for Patients With Early Inflammatory Polyarthritis

Dobkin

Liu

Abrahamowicz

et al. 2013

Arthritis Care & Research

Self Cite

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“…However, in individual patients with EIA, autoantibodies may convert or revert, while conversion appears to be prevented in some patients treated early 9,10,11 . Differences in midterm outcomes between seropositive and seronegative RA also appear blunted by early and intensive treatment 10,12 . A number of more recent RA-associated antibodies, sometimes found in RF and anti-CCP2 negative sera, are also emerging.…”

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confidence: 99%

“…But the antibody division of RA may not be as clean as was initially thought. About one-half of EIA patients are RF and/or anti-CCP2 antibody-positive at diagnosis 9,10 . However, in individual patients with EIA, autoantibodies may convert or revert, while conversion appears to be prevented in some patients treated early 9,10,11 .…”

mentioning

confidence: 99%

“…About one-half of EIA patients are RF and/or anti-CCP2 antibody-positive at diagnosis 9,10 . However, in individual patients with EIA, autoantibodies may convert or revert, while conversion appears to be prevented in some patients treated early 9,10,11 . Differences in midterm outcomes between seropositive and seronegative RA also appear blunted by early and intensive treatment 10,12 .…”

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confidence: 99%

“…A number of more recent RA-associated antibodies, sometimes found in RF and anti-CCP2 negative sera, are also emerging. For example, anti-Sa antibody positivity has low sensitivity but high specificity for RA 10,13 . While anti-CCP2 antibodies were found in 19% of FDR of NAN patients with RA, no FDR was positive for anti-Sa, although 61% of NAN RA expressed anti-Sa 14 .…”

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confidence: 99%

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