Objective: To compare 20-gauge standard pars plana vitrectomy (PPV) with transconjunctival cannulated PPV in the development of intraoperative retinal breaks and postoperative rhegmatogenous retinal detachments (RRDs) in a large series of patients undergoing PPV for macular pucker or macular hole. tation for pars plana vitrectomy (PPV) for macular pucker and macular hole continue to evolve. The latest advances include small-gauge, transconjunctival, cannulated systems; the first report on these systems was made in 2002 by Fujii and colleagues, 1 who assessed a 25-gauge system. Since that time, 23-gauge systems and 20-gauge transconjunctival cannulated systems have been developed. Potential advantages of transconjunctival cannulated vitrectomy systems include improved fluidics, a more tightly contained system, smoother entry and exit, port positioning closer to the tip for closer shaving, reduced need for sclerotomy suturing, and decreased surgical time. A recent systematic review 2 formalized other potential advantages, including decreased postoperative inflammation, increased postoperative comfort, and reduced time to obtain visual acuity improvement. This report also concluded that transconjunctival cannulated vitrectomy systems demonstrated an acceptable safety profile compared with standard 20-gauge PPV.The aim of this study was to compare standard 20-gauge PPV with transconjunctival cannulated PPV in the development of intraoperative retinal breaks and postoperative rhegmatogenous retinal detachments (RRDs) in a large series of patients undergoing PPV for macular pucker or macular hole at a tertiary care vitreoretinal practice.