Outcomes of conception subsequent to methotrexate treatment for an unruptured ectopic pregnancy

Svirsky, Ran; Ben‐Ami, Ido; Berkovitch, Matitiahu; Halperin, Reuvit; Rozovski, Uri

doi:10.1002/ijgo.12264

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…MTX has been used as a medical alternative to surgery for women with ectopic pregnancy since the 1990s (47). Previous studies demonstrated that MTX had a success rate of approximately 94% when administered to the appropriate patients (48).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of serum biomarkers and efficacy of MTX in women with ectopic pregnancy

Liu

Wen

et al. 2019

Mol Med Report

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ectopic pregnancy occurs when a fertilized ovum attaches outside the uterus. as a complication in approximately 1-2% of all pregnancies, ectopic pregnancies may cause catastrophic hemorrhage as a result of invading maternal blood vessels. Therefore, early diagnosis and timely treatment are crucial for women with ectopic pregnancy. in this study, we aimed to identify and determine the efficacy of serum biomarkers for the prompt diagnosis of ectopic pregnancy. For this purpose, the serum concentrations of progesterone, β human chorionic gonadotropin (β-hcG) and cancer antigen-125 (ca125) were detected by solid-phase, competitive binding chemiluminescent enzyme immunoassays. Flow cytometry was used to analyze the percentage of cd3 + T cells in women with ectopic pregnancy. Pathological analysis of tubal and villus tissues was performed by hematoxylin and eosin (H&e) staining. after receiving an injection of methotrexate (MTX), patients were examined by transvaginal ultrasound to detect the size of the echogenic mass. The results revealed that the serum levels of progesterone, β-HcG and CA125 were significantly decreased in women with ectopic pregnancy, whereas the percentage of cd3 + T cells was increased in women with ectopic pregnancy. Histopathological examination revealed blood clots with small tissue fragments of a tubal-type epithelium and incomplete pile structures. Five days after the MTX injection, an echogenic mass was found with a size of 1.7x1.2x1.6 cm that contained a gestational sac-like structure and a yolk sac. On the whole, the findings of this study indicate the at the joint detection of progesterone, β-HcG, ca125 serum levels and the cd3 + T cell percentage could be applied as a reliable indicator for the early diagnosis of ectopic pregnancy. MTX administration was determined to be an efficacious approach for the treatment of ectopic pregnancy.

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Section: Discussionmentioning

confidence: 99%

Evaluation of serum biomarkers and efficacy of MTX in women with ectopic pregnancy

Liu

Wen

et al. 2019

Mol Med Report

View full text Add to dashboard Cite

show abstract

Directive clinique no 414 : Prise en charge des grossesses de localisation indéterminée et des grossesses ectopiques tubaires et non tubaires

Po¹,

Thomas²,

Mills³

et al. 2021

Journal of Obstetrics and Gynaecology Canada

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Guideline No. 414: Management of Pregnancy of Unknown Location and Tubal and Nontubal Ectopic Pregnancies

Po¹,

Thomas²,

Mills³

et al. 2021

Journal of Obstetrics and Gynaecology Canada

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Outcomes of conception subsequent to methotrexate treatment for an unruptured ectopic pregnancy

Abstract: The frequency of fetal malformation in a subsequent pregnancy was low among women treated with methotrexate for ectopic pregnancy. The frequency of early missed abortion was lowest during the first 6 months after treatment with methotrexate.

Cited by 3 publications

References 13 publications

Evaluation of serum biomarkers and efficacy of MTX in women with ectopic pregnancy

Evaluation of serum biomarkers and efficacy of MTX in women with ectopic pregnancy

Directive clinique no 414 : Prise en charge des grossesses de localisation indéterminée et des grossesses ectopiques tubaires et non tubaires

Guideline No. 414: Management of Pregnancy of Unknown Location and Tubal and Nontubal Ectopic Pregnancies

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