Outcomes of contemporary management of gangrenous and non-gangrenous acute cholecystitis

Abstract

Gangrenous cholecystitis has certain clinical features and associated laboratory findings that may help to differentiate it from NGAC. It is not associated with an overall increase in complications when treated in a specialized unit.

Can red cell distribution width be used as a predictor of acute cholecystitis?

“…C-reactive protein level was also found to be elevated in AC, especially to very high values when gangrenous cholecystitis is present and Crp level is alsocorrelated with conversion to open cholecystectomy (19)(20)(21). In our study, the mean CRP level was 79.94±93.06 mg/L in the AC group and was statistically significant as compared to the CC group (p=0.030).…”

Risk factors for acute gangrenous cholecystitis in emergency general surgery patients

“…1,13 Other studies have observed a similar population of older male patients being more affected by acute gangrenous cholecystitis, often with an elevation in preoperative bilirubin. 14,15 Problematically, none of the radiological findings in this study was able to predict the possibility of necrosis, giving the surgeon no warning other than clinical suspicion for this intraoperative diagnosis.…”

Gangrenous Cholecystitis: Mortality and Risk Factors

“…13 As one of the severe complications of acute cholecystitis, GC develops in 2% to 20% of the cases with acute cholecystitis. 5,6,14 Epithelial injury by increasing gallbladder wall tension owing to vascular insufficiency arising secondary to persistent obstruction of the cystic duct gives way to the development of GC, which follows a quite rapid course. 5 The phospholipases released from cell membranes of damaged epithelium initiate heavy inflammatory reaction.…”