Outcomes of COVID-19 among patients with liver disease

Vujčić, Isidora S.

doi:10.3748/wjg.v29.i5.815

Cited by 14 publications

(5 citation statements)

References 87 publications

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“…Additionally, a meta-analysis conducted by Khoury et al reported risk ratios of 1.9 for overall mortality among cancer patients [ 32 ]. Similarly, in our study, patients with solid tumors or end-stage chronic liver disease had significantly increased risks for the severe courses, consistent with findings from previous studies [ 32 , 33 ]. Although patients with hematologic diseases and end-stage chronic kidney disease also showed a trend towards increased risk for severe outcomes, this did not reach significance, probably due to the smaller sample size for these less prevalent diseases.…”

Section: Discussionsupporting

confidence: 93%

Retrospective, Observational Analysis on the Impact of SARS-CoV-2 Variant Omicron in Hospitalized Immunocompromised Patients in a German Hospital Network—The VISAGE Study

Nachtigall,

Kwast,

Hohenstein

et al. 2024

Vaccines

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Aims: Endemic SARS-CoV-2 infections still burden the healthcare system and represent a considerable threat to vulnerable patient cohorts, in particular immunocompromised (IC) patients. This study aimed to analyze the in-hospital outcome of IC patients with severe SARS-CoV-2 infection in Germany. Methods: This retrospective, observational study, analyzed administrative data from inpatient cases (n = 146,324) in 84 German Helios hospitals between 1 January 2022 and 31 December 2022 with regard to in-hospital outcome and health care burden in IC patients during the first 12 months of Omicron dominance. As the primary objective, in-hospital outcomes of patients with COVID-19-related severe acute respiratory infection (SARI) were analyzed by comparing patients with (n = 2037) and without IC diagnoses (n = 14,772). Secondary analyses were conducted on IC patients with (n = 2037) and without COVID-19-related SARI (n = 129,515). A severe in-hospital outcome as a composite endpoint was defined per the WHO definition if one of the following criteria were met: intensive care unit (ICU) treatment, mechanical ventilation (MV), or in-hospital death. Results: In total, 12% of COVID-related SARI cases were IC patients, accounting for 15% of ICU admissions, 15% of MV use, and 16% of deaths, resulting in a higher prevalence of severe in-hospital courses in IC patients developing COVID-19-related SARI compared to non-IC patients (Odds Ratio, OR = 1.4, p < 0.001), based on higher in-hospital mortality (OR = 1.4, p < 0.001), increased need for ICU treatment (OR = 1.3, p < 0.001) and mechanical ventilation (OR = 1.2, p < 0.001). Among IC patients, COVID-19-related SARI profoundly increased the risk for severe courses (OR = 4.0, p < 0.001). Conclusions: Our findings highlight the vulnerability of IC patients to severe COVID-19. The persistently high prevalence of severe outcomes in these patients in the Omicron era emphasizes the necessity for continuous in-hospital risk assessment and monitoring of IC patients.

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Section: Discussionsupporting

confidence: 93%

Retrospective, Observational Analysis on the Impact of SARS-CoV-2 Variant Omicron in Hospitalized Immunocompromised Patients in a German Hospital Network—The VISAGE Study

Nachtigall,

Kwast,

Hohenstein

et al. 2024

Vaccines

View full text Add to dashboard Cite

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“…COVID-19 has been associated with liver injury, even in patients without pre-existing liver conditions [23] . The extent of liver injury in COVID-19 cases is generally mild [24] and is more pronounced in males, older adults, and people with high body mass index.…”

Section: Discussionmentioning

confidence: 99%

Impact of prior SARS-CoV-2 infection on postoperative recovery in patients with hepatocellular carcinoma resection

Fang,

Gan,

et al. 2024

Preprint

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BACKGROUND The impact of prior SARS-CoV-2 infection on postoperative recovery of patients who underwent liver resection for hepatocellular carcinoma (HCC) remains uncertain given the lack of sufficient evidence. AIM To investigate the impact of prior SARS-CoV-2 infection on postoperative recovery of patients who underwent liver resection for hepatocellular carcinoma (HCC). METHODS Patients who were pathologically diagnosed with HCC and underwent elective partial hepatectomy in Guangdong Provincial People’s Hospital between January 2022 and April 2023 were enrolled in this retrospective cohort study. The patients were divided into two groups based on their history of SARS-CoV-2 infection. Rehabilitation parameters, including postoperative liver function, incidence of complications, and hospitalization expenses, were compared between the two groups. Propensity score matching (PSM) was performed to reduce confounding bias. RESULTS We included 172 patients (58 with and 114 without prior SARS-CoV-2 infection) who underwent liver resection for HCC. No significant differences in the rehabilitation parameters were observed between the two groups. After PSM, 58 patients were selected from each group to form the new comparative groups. Similar results were obtained within the population after PSM. CONCLUSION Prior SARS-CoV-2 infection does not appear to affect postoperative rehabilitation, including liver function, postoperative complications, or hospitalization expenses among patients with HCC after elective partial hepatectomy.

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“…Of the approximately 1700 patients with chronic liver disease at an Italian liver unit, by transitioning to a telecare model of care, none were reported to have contracted COVID‐19 5 . This is an important finding because liver dysfunction in COVID‐19 patients is a risk factor for severe illness and death 40 …”

Section: Hepatologymentioning

confidence: 99%

Review article: Telecare in gastroenterology—Within the COVID‐19 pandemic and beyond

Hakak,

Patel,

Gearry

2024

Aliment Pharmacol Ther

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SummaryBackgroundTelehealth is a growing model of care, greatly accelerated with the demands of the COVID‐19 pandemic. Telecare is a synchronous audio‐visual or audio‐only format of health delivery.AimsTo evaluate the existing literature on telecare within adult gastroenterology subspecialties to determine if outcomes are comparable to traditional in‐person consultations and to highlight the Pokapū Network, a local initiative in the Lakes Region of New Zealand, amongst these international findings.MethodsWe completed an OVID MEDLINE search using the terms gastroenterology, endoscopy, digestive system, inflammatory bowel disease, functional, hepatology, liver, telemedicine, telehealth, videoconferencing, remote consultation, video clinic and telephone clinic.ResultsPatients showed positive attitudes towards telecare and, in several reports, would elect to have telecare consults in the future. Telecare reduces travel time and out‐of‐pocket costs for patients and the need for patients to take time off work. Generally, patients engaging with telecare show equivalent health outcomes to patients engaging with traditional models of care. Patients from ethnic minority groups or lower socio‐economic backgrounds, or who are older, are less likely to complete a ‘successful’ telecare consult.ConclusionTelecare is a useful model of care to allow gastroenterology centres to function within the context of COVID‐19 isolation and beyond. It has significant benefits for patients who face geographical and financial barriers to accessing healthcare. Telecare models such as the Pokapū Network hold promise in reducing inequities for gastroenterology patients. Such models must be introduced with consideration of digital disparities that exist amongst patients to avoid worsening the digital divide.

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Outcomes of COVID-19 among patients with liver disease

Cited by 14 publications

References 87 publications

Retrospective, Observational Analysis on the Impact of SARS-CoV-2 Variant Omicron in Hospitalized Immunocompromised Patients in a German Hospital Network—The VISAGE Study

Retrospective, Observational Analysis on the Impact of SARS-CoV-2 Variant Omicron in Hospitalized Immunocompromised Patients in a German Hospital Network—The VISAGE Study

Impact of prior SARS-CoV-2 infection on postoperative recovery in patients with hepatocellular carcinoma resection

Review article: Telecare in gastroenterology—Within the COVID‐19 pandemic and beyond

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