Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis

Elshaarawy, Omar; Aman, Aya; Zakaria, Hazem; Zakareya, Talaat; Gomaa, Asmaa; Elshimi, Esam; Abdelsameea, Eman

doi:10.4251/wjgo.v13.i5.424

Cited by 10 publications

(6 citation statements)

References 29 publications

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“…The MELD score is traditionally used for patients with decompensated cirrhosis on the waiting list for LT [3][4][5][6]. However, multiple studies have reported that higher MELD scores are associated with poor outcomes of patients with HCC undergoing LR [24,25].…”

Section: Discussionmentioning

confidence: 99%

Survival outcome was superior with liver resection versus percutaneous radiofrequency ablation in patients with single hepatocellular carcinoma 2-3 cm

Yen,

Liu,

Hung

et al. 2024

Preprint

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Purpose Previous reports are ambiguous about the efficacy of percutaneous radiofrequency ablation (pRFA) in treating patients with early-stage hepatocellular carcinoma (HCC) with a single 2.0–3.0 cm tumor. Our study compared outcomes of pRFA and liver resection (LR) in these patients. Methods From 2011 to 2021, 378 patients undergoing LR and 238 patients undergoing pRFA for early-stage HCC with a single 2.0–3.0 cm tumor and Child–Pugh class A liver disease were enrolled. Survival analysis was performed using the Kaplan − Meier method after propensity score matching (PSM) by age, sex, serum alpha-fetoprotein level, and the Model for End-Stage Liver Disease score. Results In multivariate analysis, pRFA vs. LR was the only comparison associated with five-year OS (HR: 2.278; 95% CI: 1.515–3.427; p < 0.001) and five-year RFS (HR: 1.995; 95% CI: 1.505–2.643; p < 0.001). After PSM, LR was associated with a significantly higher survival benefit than pRFA (five-year OS: 82% vs. 61%; p = 0.001; five-year RFS: 60% vs. 35%; p = 0.001). Conclusion LR offers a higher survival benefit than pRFA for patients with early-stage HCC with a single 2.0–3.0 cm tumor.

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Section: Discussionmentioning

confidence: 99%

Survival outcome was superior with liver resection versus percutaneous radiofrequency ablation in patients with single hepatocellular carcinoma 2-3 cm

Yen,

Liu,

Hung

et al. 2024

Preprint

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“…In addition, extremely high preoperative α-fetoprotein level was associated with increased rates of R1 resection and vascular invasion (67). In another report, preoperative model of end-stage liver disease, grade of post hepatectomy liver failure and HCC recurrence were independent predictors for patient survival (68).…”

Section: Important Considerationsmentioning

confidence: 98%

Surgical approach to achieve R0 resections in primary and metastatic liver tumors: a literature review

Vargas¹,

Dar²,

Fernandes³

et al. 2023

J Gastrointest Oncol

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Background and Objective: Primary and metastatic liver tumors are a significant cause of mortality worldwide. Regardless of the etiology of the tumor, macro-and microscopically clear margins (R0) while preserving adequate function of the remaining organ are the main goals after liver resections. However, technically challenging procedures are required to achieve R0 resection. Currently, there is no consensus of which should be the ideal minimal safety margin for liver tumor resections, with contrasting reports in regards of safety, tumor recurrence and overall outcomes following R0. Therefore, we aim to review current worldwide surgical practices to achieve R0 resections for primary and metastatic liver tumors in challenging surgical techniques and their reported outcomes.Methods: PubMed database, Google Scholar, and OVID Medline were searched for peer-reviewed original articles related to surgical techniques performed to achieve R0 resections in the setting of primary and/or metastatic liver tumors. An up-to-date review of English-language articles published between 2015 to July 2022 was performed.

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“…However, several aspects could be enhanced or explored further[ 3 ]. First, while the present study effectively established the predictive value of the NLR, Fib4 levels, and APRI, it primarily focused on a retrospective patient cohort.…”

Section: To the Editormentioning

confidence: 99%

Exploring predictive markers for liver failure post-hepatectomy in hepatocellular carcinoma patients

Zhang,

Ma,

Zhu

et al. 2024

World J Gastrointest Surg

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This letter to the editor addresses the study titled “Predictive value of NLR, Fib4, and APRI in the occurrence of liver failure after hepatectomy in patients with hepatocellular carcinoma” by Kuang et al in the World Journal of Gastrointestinal Surgery . The study acknowledges the comprehensive patient data analysis while suggesting that there is a need for further discussion on the clinical applicability of these markers across diverse patient populations. This letter recommends prospective studies for validation and considers the influence of confounding factors. This finding underscores the significance of this study in improving hepatocellular carcinoma management.

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Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis

Cited by 10 publications

References 29 publications

Survival outcome was superior with liver resection versus percutaneous radiofrequency ablation in patients with single hepatocellular carcinoma 2-3 cm

Survival outcome was superior with liver resection versus percutaneous radiofrequency ablation in patients with single hepatocellular carcinoma 2-3 cm

Surgical approach to achieve R0 resections in primary and metastatic liver tumors: a literature review

Exploring predictive markers for liver failure post-hepatectomy in hepatocellular carcinoma patients

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