Outcomes of Definitive Radiation Therapy for Primary Vaginal Carcinoma

Greenwalt, Julie; Amdur, Robert J.; Morgan, Linda; Castagno, Jacqueline; Markham, Merry Jennifer; Rich, Shayna E.; Daily, Karen; Morris, Ann; Yeung, Raymond W.

doi:10.1016/j.ijrobp.2013.06.337

Cited by 2 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From a total of 199 retrieved studies, 13 articles reporting data on 793 patients (median, 45; range, 26–138) met our inclusion criteria , as shown in Figure . The patients included in the analyzed studies were treated between 1959 and 2014, and the median follow‐up for the whole population ranged from 27.6 to 90.0 months.…”

Section: Resultsmentioning

confidence: 99%

“…The treatment strategy was different in each study and involved combinations of EBRT, BT (endocavitary [EC] and/or interstitial [IT]), C‐CT, and surgical resection. Different treatment combinations of radiation therapy were used (EBRT + BT and/or EBRT alone and/or BT alone); a majority of the patients were treated with a combination of EBRT and BT (74.2%) . In ten studies, a minority of patients (20.9%) received a combination of RT and chemotherapy .…”

Section: Resultsmentioning

confidence: 99%

“…Concerning radiotherapy technique, a large variety of beam arrangements (antero‐posterior/postero‐anterior [AP/PA], 4‐fields, three‐dimensional conformal RT [3D‐CRT], intensity‐modulated RT [IMRT], volumetric modulated arc therapy [VMAT]) were reported across studies, and these data were incomplete or lacking in three papers. The whole pelvis was irradiated alone, with or without inguinal nodes , or with or without para‐aortic nodes . Target volume data were lacking in two studies .…”

Section: Resultsmentioning

confidence: 99%

“…The Common Terminology Criteria for Adverse Events scale , the Radiation Therapy Oncology Group (RTOG)/European Organization for Research and Treatment of Cancer scale , or the Franco‐Italian glossary were used to grade and report toxicity. Two papers failed to report the grading scale , and toxicity data were totally unreported in one paper .…”

Section: Resultsmentioning

confidence: 99%

“…Two papers failed to report the grading scale , and toxicity data were totally unreported in one paper . Short‐term adverse effects data were lacking in a majority of studies ; the most frequently reported short‐term side effects were genitourinary and gastrointestinal , whereas hematological and skin toxicities were less frequently reported, as detailed in Table .…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Definitive Radiotherapy in Invasive Vaginal Carcinoma: A Systematic Review

Guerri¹,

Perrone

Buwenge

et al. 2018

The Oncologist

View full text Add to dashboard Cite

Only retrospective studies, in a limited number, have been published on RT in VC in the past decade, with significant heterogeneity in terms of treatment characteristic and evaluation criteria. Clinical results were strongly influenced by tumor stage. Prospective randomized studies are needed to improve patients' outcomes, especially in advanced-stage disease.;23:1-10 IMPLICATIONS FOR PRACTICE: This study systematically reviews the recent literature on the role of definitive radiotherapy in the management of vaginal cancer and presents comprehensive data on clinical outcome and toxicity. The prognosis of patients is dismal, with a 5-year overall survival of approximately 50%. Early stage of the disease, small tumor size, previous hysterectomy, high pretreatment/treatment hemoglobin levels, and patients' age were correlated with a better clinical outcome. A brachytherapy boost should be delivered, especially in patients with higher-stage disease. The addition of concurrent weekly cisplatin should be considered in most patients, and transfusion should be used to maintain high hemoglobin levels.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%