Outcomes of Heart Block in Myocarditis: A Review of 31,760 Patients

Ogunbayo, Gbolahan; Elayi, Samy-Claude; Ha, Le Dung; Olorunfemi, Odunayo; Elbadawi, Ayman; Saheed, Deola; Sorrell, Vincent L.

doi:10.1016/j.hlc.2017.12.005

Cited by 45 publications

(37 citation statements)

References 12 publications

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“…High-degree AVB/complete AVB, with an incidence ranging from 1.1 to 14.8%, has been associated with the severity of the disease, which is similar to the results of the present study (6,7,14). The present study indicated that high-degree AVB was an independent predictive factor of FM and the incidence rate of CA (7.2 vs. 28.1%; P= 0.001) was different between patients with non-AVB and high-degree AVB.…”

Section: Discussionsupporting

confidence: 91%

“…The present study indicated that high-degree AVB was an independent predictive factor of FM and the incidence rate of CA (7.2 vs. 28.1%; P= 0.001) was different between patients with non-AVB and high-degree AVB. This result was higher compared with the incidence rate of CA determined by Ogunbayo et al (7), who reported a difference between patients with non-heart block and high-degree AVB (CA incidence of 1.7 vs. 17.4%, respectively; P<0.001). In addition, the present study indicated that 6 patients had both non-advanced AVB and high-degree AVB, which indicated that high-degree AVB and non-advanced AVB may be present in parallel as the disease progresses.…”

Section: Discussioncontrasting

confidence: 59%

“…However, studies on this topic are currently limited, focusing on abnormal ECG findings and their rate of abundance in patients with acute myocarditis (4,8). Furthermore, most of the aforementioned ECG findings (such as VT, AVB, QRS prolongation and low voltage) are associated with the severity of myocarditis (5,7,8). However, these studies are mainly on certain ECG changes for predicting outcomes, and the associations between ECG findings and the severity are simply mentioned (5,7).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, most of the aforementioned ECG findings (such as VT, AVB, QRS prolongation and low voltage) are associated with the severity of myocarditis (5,7,8). However, these studies are mainly on certain ECG changes for predicting outcomes, and the associations between ECG findings and the severity are simply mentioned (5,7). Fulminant myocarditis (FM) is an acute and severe form of myocarditis (9).…”

Section: Introductionmentioning

confidence: 99%

“…FM is associated with a wide variety of serious arrhythmias such as VF and AVB (11). AVB is an important ECG aberration in patients with myocarditis, which is associated with the severity of the disease (7). However, the association between AVB and CA remains to be fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Role of electrocardiograms in assessment of severity and analysis of the characteristics of ST elevation in acute myocarditis: A two‑centre study

Chen

et al. 2020

Exp Ther Med

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Acute myocarditis is a severe disease with a high mortality rate and various dynamic changes visible on electrocardiograms (ECGs). The purpose of the present study was to investigate ECG findings of patients with acute myocarditis, ECG findings associated with fulminant myocarditis (FM) and the characteristics of ST elevation on admission. A retrospective analysis of 1,814 ECGs of 274 consecutive patients with acute myocarditis aged ≥13 years, who were hospitalized in two centres between August 2007 and November 2019, was performed. A total of 251 patients with myocarditis (91.6%) presented with ECG abnormalities. The most common ECG findings were T-wave inversion and ST elevation. Univariate logistic regression analysis demonstrated that 12 ECG findings were associated with FM. Multivariate regression analysis revealed that the independent predictive factors for FM included ventricular tachycardia, high-degree atrioventricular block, sinus tachycardia, low voltage and QRS duration of ≥120 msec (all P<0.05). A total of 112 cases displayed ST elevation at admission. Of these, ST elevation without T-wave inversion (n=87) was associated with a shorter duration of cardiac symptoms (1.5 vs. 3.1 days; P<0.001) compared with ST elevation with T-wave inversion (n=25). Of the aforementioned 87 patients, 71 (81.6%) presented with T-wave inversion at the hospital. The median time from the onset of cardiac symptoms to T-wave inversion was 4.0 days. In conclusion, patients with acute myocarditis exhibited various dynamic changes on ECG. Thus, ECGs should be widely used for the assessment of severity and the characteristics of ST elevation on admission.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Role of electrocardiograms in assessment of severity and analysis of the characteristics of ST elevation in acute myocarditis: A two‑centre study

Chen

et al. 2020

Exp Ther Med

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Electrocardiogram Findings Worthy of Vigilance—A Rare and Fatal Disease

2022

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Impact of atrial fibrillation on patients hospitalized for acute myocarditis: Insights from a nationally‐representative United States cohort

Subahi

Akintoye

Yassin

et al. 2019

Clinical Cardiology

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BackgroundAtrial fibrillation (AF) is associated with increased all‐cause mortality in the general population. However, the impact of AF on the in‐hospital outcomes of acute myocarditis (AM) patients is not well characterized.MethodsPatients (age ≥ 18 years) with a primary diagnosis of AM in the National Inpatient Sample from 2007 to 2014 were included, using the ICD‐9‐CM diagnostic codes. We compared the in‐hospital outcomes between the AF group and propensity score‐matched control group without AF.ResultsAF was reported in 602 (9%) of the AM patients. Compared to those without AF, AM patients with AF experienced higher in‐hospital mortality (odds ratio [OR] 1.7, 95% confidence interval [CI] 1.1‐2.7, P = 0.02). AF was associated with higher risk of cardiogenic shock (OR 1.9, 95% CI 1.3‐2.8, P < 0.001), cardiac tamponade (OR 5.6, 95% CI 1.2‐25.3, P = 0.002) and acute kidney injury (OR 1.6, 95% CI 1.1‐2.1, P = 0.02). Furthermore, patients with AF were more likely to have non‐routine hospital discharge (31.6% vs 38.4% P = 0.02), longer length of stay and higher cost of hospitalization.ConclusionsAF was associated with increased risk of in‐hospital mortality and complications in patients admitted to the hospital with acute myocarditis.

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Outcomes of Heart Block in Myocarditis: A Review of 31,760 Patients

Cited by 45 publications

References 12 publications

Role of electrocardiograms in assessment of severity and analysis of the characteristics of ST elevation in acute myocarditis: A two‑centre study

Role of electrocardiograms in assessment of severity and analysis of the characteristics of ST elevation in acute myocarditis: A two‑centre study

Electrocardiogram Findings Worthy of Vigilance—A Rare and Fatal Disease

Impact of atrial fibrillation on patients hospitalized for acute myocarditis: Insights from a nationally‐representative United States cohort

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