Outcomes of hepatectomy for noncirrhotic hepatocellular carcinoma: A systematic review

Zhou, Yanming; Lei, Xiaoyi; Wu, Lupeng; Wu, Xiu-Rong; Xu, Donghui; Li, Bin

doi:10.1016/j.suronc.2014.11.001

Cited by 38 publications

(30 citation statements)

References 36 publications

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“…Nevertheless, despite a greater tumour burden, the conserved function of the non‐cirrhotic liver generally allows for reasonably safe, extensive resections. In our series, 23 (71.9%) patients underwent a major hepatic resection, with very low perioperative morbidity and mortality, similar to other studies . However, despite extensive resections the noted absence of underlying disease low mortality and POM rates, the prognosis is ominous.…”

Section: Discussionsupporting

confidence: 86%

“…In our series, 23 (71.9%) patients underwent a major hepatic resection, with very low perioperative morbidity and mortality, similar to other studies. 14,28,34,41,42 However, despite extensive resections the noted absence of underlying disease low mortality and POM rates, the prognosis is ominous. Statistically, the SV at 1 and 2 years (96.7% and 73.4%, respectively) was similar to that of other publications, while the SV at 3 and 5 years (17.3% and 17.3%, respectively) was even lower than that reported by other authors.…”

Section: Discussionmentioning

confidence: 99%

“…Liver resection is the treatment of choice for HCC‐NCL . Good liver function of the remnant liver makes possible broad resections, with low rates of post‐operative morbidity (POM) and mortality, even in large tumours …”

Section: Introductionmentioning

confidence: 99%

“…11 Liver resection is the treatment of choice for HCC-NCL. [12][13][14][15] Good liver function of the remnant liver makes possible broad resections, with low rates of post-operative morbidity (POM) and mortality, even in large tumours. 3,14,15 The aim of this study was to describe POM and survival (SV) of surgically treated patients with HCC-NCL, and to identify the possible variables associated with prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Surgical treatment results of hepatocellular carcinoma in non‐cirrhotic liver in southern Chile: case series with follow‐up

Manterola

Grande

Otzen

et al. 2019

ANZ Journal of Surgery

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Background Hepatocellular carcinoma is the most frequent primary tumour of the liver. Although often associated with chronic liver disease, it can also occur in non‐cirrhotic livers. The aim of this study was to describe post‐operative morbidity (POM), and survival of patients with hepatocellular carcinoma in non‐cirrhotic liver treated surgically, and to identify variables associated with prognosis. Methods Case series of patients who underwent surgery for hepatocellular carcinoma in non‐cirrhotic liver at Clínica RedSalud Mayor de Temuco, Chile (2001–2017), were studied. The minimum follow‐up time considered was 12 months. Principal outcomes were development of POM and survival. Other variables of interest were age, sex, tumour diameter, surgical time, hospital stay, follow‐up time, need for surgical re‐intervention, mortality, vascular and lymph node invasion and staging. Descriptive and analytic statistics were calculated. Results A total of 32 patients were studied. They were characterized by a mean age of 67.3 ± 7.2 years, 62.5% of whom were men. Averages of tumour diameter, surgical time and hospitalization were 12.0 ± 2.6 cm, 114.4 ± 32.3 min and 7.2 ± 2.9 days, respectively. POM was 31.3%. There was no mortality and there were no re‐interventions. The overall actuarial survival at 1, 2 and 3 years was 96.8%, 73.4% and 17.3%, respectively. Lower survival was verified in patients with vascular invasion, lymph node infiltration and stages III and IVa. Conclusion Despite the tumour diameter and extent of the resections, POM in patients with hepatocellular carcinoma in non‐cirrhotic liver is moderate. However, its prognosis is poor. Vascular invasion, lymph node invasion and advances stages were associated with worse survival.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Surgical treatment results of hepatocellular carcinoma in non‐cirrhotic liver in southern Chile: case series with follow‐up

Manterola

Grande

Otzen

et al. 2019

ANZ Journal of Surgery

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“…A metanalysis by Zhou et al (14), which included 1,333 patients with HCC-NCL and 1,980 patients with HCC-C, confirmed that HCC-NCL patients present with better liver function, larger tumors and more advanced disease. However, these authors found no significant differences © Annals of Translational Medicine.…”

Section: Clinico-pathological Featuresmentioning

confidence: 94%

Long-term survival with repeated resections of recurrent hepatocellular carcinoma in a non-cirrhotic liver: case report and brief review of the literature

et al. 2016

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A healthy and asymptomatic 55-year-old woman underwent a complete (R0) non-anatomical resection of an incidentally detected solitary hepatocellular carcinoma (HCC) in a non-cirrhotic liver. Six years following the initial R0 non-anatomical resection, intrahepatic recurrence was diagnosed and the patient underwent a second R0 non-anatomical resection. At 12.5 years following the initial resection, a further intrahepatic recurrence was diagnosed, which was once again completely resected by left lateral hepatectomy. This represents one of the longest reported periods between initial resection and HCC recurrence, following repeated R0 resections in the absence of cirrhosis. The appropriate surveillance period and genetic testing protocol for such cases remains to be established.

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Diagnostic performance of CT/MRI LI-RADS v2018 in non-cirrhotic hepatitis C virus infection

Cao,

Shon,

Yoon

et al. 2024

Abdom Radiol

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Outcomes of hepatectomy for noncirrhotic hepatocellular carcinoma: A systematic review

Cited by 38 publications

References 36 publications

Surgical treatment results of hepatocellular carcinoma in non‐cirrhotic liver in southern Chile: case series with follow‐up

Surgical treatment results of hepatocellular carcinoma in non‐cirrhotic liver in southern Chile: case series with follow‐up

Long-term survival with repeated resections of recurrent hepatocellular carcinoma in a non-cirrhotic liver: case report and brief review of the literature

Diagnostic performance of CT/MRI LI-RADS v2018 in non-cirrhotic hepatitis C virus infection

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