Outcomes of intensive care unit patients with COVID‐19: a nationwide analysis in Russia

Moiseev, Sergey; Avdeev, S. N.; Brovko, Michail; Bulanov, Nikolay; Tao, E.; Fоmin, Victоr

doi:10.1111/anae.15265

“…Consistent with other studies, including those from the neighbouring Uzbekistan and Russia 1,17–20,24,27 , older age was a key contributor to COVID-19 severity and mortality, and the non-survivor group consisted predominantly of older men. The cohort’s median age (36 years) was higher than the Kazakhstan median (31 years) 28 and identical to that of COVID-19 patients in Uzbekistan 27 .…”

Section: Discussionsupporting

confidence: 88%

Epidemiological and Clinical Characteristics, and Virologic Features of COVID-19 Patients in Kazakhstan: a Nation-Wide, Retrospective, Cohort Study

Yegorov

¹

,

Goremykina

²

,

Иванова

³

et al. 2021

Preprint

1

0

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BackgroundThe earliest coronavirus disease-2019 (COVID-19) cases in Central Asia were announced in March 2020 by Kazakhstan. Despite the implementation of aggressive measures to curb infection spread, gaps remain in the understanding of the clinical and epidemiologic features of the regional pandemic.MethodsWe did a retrospective, observational cohort study of patients with laboratory-confirmed COVID-19 in Kazakhstan between February and April 2020. We compared demographic, clinical, laboratory and radiological data of patients with different COVID-19 severities on admission. Univariable and multivariable logistic regression was used to assess factors associated with disease severity and death. Whole-genome SARS-CoV-2 analysis was performed in 53 patients without a recent history of international travel.FindingsOf the 1072 patients with laboratory-confirmed COVID-19 in March-April 2020, the median age was 36 years (IQR 24–50) and 484 (45%) were male. On admission, 683 (64%) participants had mild, 341 (32%) moderate, and 47 (4%) severe-to-critical COVID-19 manifestation; 20 deaths (1.87%) were reported at study exit. Multivariable regression indicated increasing odds of severe disease associated with older age (odds ratio 1.05, 95% CI 1.03-1.07, per year increase; p<0.001), the presence of comorbidities (2.13, 95% CI 1.07-4.23; p<0.031) and elevated white blood cell count (WBC, 1.14, 95% CI 1.01-1.28; p<0.032) on admission, while older age (1.09, 95% CI 1.06-1.12, per year increase; p<0.001) and male sex (5.97, 95% CI 1.95-18.32; p<0.002) were associated with increased odds of death. The Kazakhstan SARS-CoV-2 isolates grouped into seven distinct lineages O/B.4.1, S/A.2, S/B.1.1, G/B.1, GH/B.1.255, GH/B.1.3 and GR/B.1.1.10.InterpretationOlder age, comorbidities, increased WBC count, and male sex were risk factors for COVID-19 disease severity and mortality in Kazakhstan. The broad SARS-CoV-2 diversity suggests multiple importations and community-level amplification, likely predating the declaration of state emergency. Continuous epidemiologic and genomic surveillance may be critical for a better understanding of the regional COVID-19 dynamics.

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“…Unfortunately, we have limited published data from Central-Eastern European ICUs [19][20][21][22] to compare our data to, but the current results on mortality match with those published on the national and international websites, suggesting that mortality of COVID-19 patients in the six countries included in the current analysis was somewhat higher than in our Western European counterparts [6].…”

Section: Mortalitymentioning

confidence: 62%

Results of the SepsEast Registry to define the Characteristics in Coronavirus Disease in Central-Eastern Europe between March 2020-February 2021: an international, multicentre retrospective study of the SEARCH-COVID-19 Study Group

Beneš

¹

,

Jankowski

²

,

Szułdrzyński

³

et al. 2022

Preprint

0

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Background: The coronavirus disease (COVID-19) pandemic caused unprecedented research activity all around the world but publications from Central-Eastern European countries remain scarce. Therefore, our aim was to characterise the features of the pandemic in the intensive care units (ICUs) among members of the SepsEast (Central-Eastern European Sepsis Forum) initiative.Methods: We conducted a retrospective, international, multicentre study between March 2020-February 2021. All adult patients admitted to the ICU with pneumonia caused by COVID-19 were enrolled. Data on baseline and treatment characteristics, organ support and mortality were collected. Results: Eleven centres from six countries provided data from 2139 patients. Patient characteristics were; median 68, [IQR 60-75] years of age; males: 67%; body mass index: 30.1 [27.0-34.7]; and 88% comorbidities. Overall mortality was 55%, which increased from 2020 to 2021 (p=0.004). The major causes of death were respiratory (37%), cardiovascular (26%) and sepsis with multiorgan failure (21%). 1061 patients received invasive mechanical ventilation (mortality: 66%) without extracorporeal membrane oxygenation (n=54). The rest of the patients received non-invasive ventilation (n=129), high flow nasal oxygen (n=317), conventional oxygen therapy (n=122), as the highest level of ventilatory support, with mortality of 50%, 39% and 22%, respectively. Conclusions: This is the largest COVID-19 dataset from Central-Eastern European ICUs to date. The high mortality observed especially in those receiving invasive mechanical ventilation renders the need of establishing national-international ICU registries and audits in the region that could provide high quality, transparent data, not only during the pandemic, but also on a regular basis.

show abstract

“…Unfortunately, we have limited published data from Central-Eastern European ICUs [19][20][21][22] to compare our data to, but the current results on mortality match with those published on the national and international websites, suggesting that mortality of COVID-19 patients in the six countries included in the current analysis was somewhat higher than in our Western European counterparts [6].…”

Section: Mortalitymentioning

confidence: 67%

Results of the SepsEast Registry to define the Characteristics in Coronavirus Disease in Central-Eastern Europe between March 2020-February 2021: an international, multicentre retrospective study of the SEARCH-COVID-19 Study Group

Benes

¹

,

Jankowski

²

,

Szułdrzyński

³

et al. 2022

Preprint

0

View full text Add to dashboard Cite

Background: The coronavirus disease (COVID-19) pandemic caused unprecedented research activity all around the world but publications from Central-Eastern European countries remain scarce. Therefore, our aim was to characterise the features of the pandemic in the intensive care units (ICUs) among members of the SepsEast (Central-Eastern European Sepsis Forum) initiative.Methods: We conducted a retrospective, international, multicentre study between March 2020-February 2021. All adult patients admitted to the ICU with pneumonia caused by COVID-19 were enrolled. Data on baseline and treatment characteristics, organ support and mortality were collected. Results: Eleven centres from six countries provided data from 2139 patients. Patient characteristics were; median 68, [IQR 60-75] years of age; males: 67%; body mass index: 30.1 [27.0-34.7]; and 88% comorbidities. Overall mortality was 55%, which increased from 2020 to 2021 (p=0.004). The major causes of death were respiratory (37%), cardiovascular (26%) and sepsis with multiorgan failure (21%). 1061 patients received invasive mechanical ventilation (mortality: 66%) without extracorporeal membrane oxygenation (n=54). The rest of the patients received non-invasive ventilation (n=129), high flow nasal oxygen (n=317), conventional oxygen therapy (n=122), as the highest level of ventilatory support, with mortality of 50%, 39% and 22%, respectively. Conclusions: This is the largest COVID-19 dataset from Central-Eastern European ICUs to date. The high mortality observed especially in those receiving invasive mechanical ventilation renders the need of establishing national-international ICU registries and audits in the region that could provide high quality, transparent data, not only during the pandemic, but also on a regular basis.

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Outcomes of intensive care unit patients with COVID‐19: a nationwide analysis in Russia

Cited by 12 publications

References 2 publications

Epidemiological and Clinical Characteristics, and Virologic Features of COVID-19 Patients in Kazakhstan: a Nation-Wide, Retrospective, Cohort Study

Epidemiological and Clinical Characteristics, and Virologic Features of COVID-19 Patients in Kazakhstan: a Nation-Wide, Retrospective, Cohort Study

Results of the SepsEast Registry to define the Characteristics in Coronavirus Disease in Central-Eastern Europe between March 2020-February 2021: an international, multicentre retrospective study of the SEARCH-COVID-19 Study Group

Results of the SepsEast Registry to define the Characteristics in Coronavirus Disease in Central-Eastern Europe between March 2020-February 2021: an international, multicentre retrospective study of the SEARCH-COVID-19 Study Group

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