Outcomes of Invasive Meningococcal Disease in Adults and Children in Canada Between 2002 and 2011: A Prospective Cohort Study

Abstract

Outcomes following IMD remain poor in this resource-rich setting in the 21st century. These data identify priorities for clinical management of adults and children with IMD, and provide prognostic information for affected patients and their families and cost-effectiveness analyses for meningococcal vaccine programs.

A case report on meningococcal septicaemia in Kalabazaar, Thimphu, November 2016

“…The hospitalized patients are more likely to have their circulatory status monitored with early and aggressive management of shock. 2 Meningococcal septicaemia in children develops when the initial host response to infection becomes inappropriately amplified and dysregulated. After the initial presentation of fever and pharyngitis, the disease may progress to fulminant fatal disease with disseminated intravascular coagulation, hypotension, septic shock and ultimately organ failure.…”

“…11 Complications with hearing loss and seizures were also reported in children below five years of age. 2 The important risk factor in the disease development is the nasopharyngeal carriage. The human nasopharynx is the only known reservoir for Neisseria meningitidis and spread by droplets of respiratory or throat secretions from carriers.…”

“…1 The infection causes approximately 500,000 cases of septicaemia and meningitis globally every year, although incidence rate vary from < 1 per 100,000 per year in North America and Europe to 10-1000 per 100,000 per year in the meningitis belt of sub-Saharan Africa. 2 The peak incidence of invasive meningococcal disease (IMD) occurs in children between six months and two years of age followed by adolescents and young adults. 3 Lethality of sepsis is over 20% in children and thus prevention is a priority.…”

Clinical and Epidemiological Differences Among Meningococcal C Conjugate Vaccine Failures and Non-Vaccinated Cases

“…Sadarangani et al, studied the risk factors for death and complications, and found that age, shock, seizures, bruising, abnormal platelet count, symptoms onset within 24 hours of admission or admission to the intensive care unit were independently associated with death [38]. Similarly, we found that age, seizures/collapse/shock/ coma and abnormal platelet count were independently associated to death and heart failure was the main risk factor for death in all, non-vaccinated cases and septicaemia cases.…”

Інтенсивна Терапія Тяжких Та Блискавичних Форм Менінгококової Інфекції В Дітей

“…Уперше менінгококову інфекцію (МІ) описав Vieusseux у Швейцарії у 1805 р. Менінгокок (Neisseria meningitidis) уперше був ідентифікований у спинно-мозковій рідині хворого на менінгіт Weichselbaum у 1887 р. За даними ВООЗ, у 2000-ні роки МІ стала причиною 171 000 смертельних випадків у всьому світі [1]. Neisseria meningitidis викликає 500 000 ви-падків септицемії та менінгіту у світі щорічно.…”