Outcomes of Malignant Ovarian Germ-Cell Tumors Treated in Chiang Mai University Hospital over a Nine Year Period

Neeyalavira, Vithida; Suprasert, Prapaporn

doi:10.7314/apjcp.2014.15.12.4909

Cited by 16 publications

(13 citation statements)

References 12 publications

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“…Resection after chemotherapy may be safer than primary tumor resection. Single chemotherapy with methotrexate is beneficial for gestational choriocarcinoma in the mother, but not improve the outcome in children [16]. In this case, the patient treated with BEP regimen due to the diagnosis tend to the nongestational choriocarcinoma.…”

Section: Discussionmentioning

confidence: 86%

Choriocarcionoma in an Infantile Patient

Pradjatmo¹

2015

Gen Med (Los Angel)

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Clinical diagnosis of choriocarcinoma may be difficult in post-menopause or children and ectopic origin. According to its histologic origin, it is classified as gestational or nongestational choriocarcinoma. Gestational choriocarcinoma its origin derived from placental trophoblast and nongestational choriocarcinoma-derived from a germ cell. However, DNA and genetic analysis can be used to define the origin of choriocarcinoma. Usually, the DNA examination and genetic analysis have not been used widely in clinical services. In this case the diagnosis to considered as a primary nongestational choriocarcinoma just based on clinical and laboratory finding. This article is aimed to remind the doctors who treat cases choriocarcinoma and is no doubt in deciding whether the origin of the disease from gestational or nongestational should carry out an investigation DNA and genetic analysis.

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Section: Discussionmentioning

confidence: 86%

Choriocarcionoma in an Infantile Patient

Pradjatmo¹

2015

Gen Med (Los Angel)

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“…Similarly, Mangili et al [17], announced a recurrence rate of 18% in a study of 123 patients of MOGT among whom dysgerminoma was 40% and stage I was 71%. Additionally, Neeyalavira & Suprasert [32] (76 patients) reported 12 recurrent cases (15.8%). Dysgerminoma constituted only 25%, however, stage 1 in their series represented 67%.…”

Section: Discussionmentioning

confidence: 98%

Pediatric and Adolescent Malignant Ovarian Tumors: Mansoura 5 - Year Experience

Sarhan¹,

Halim²,

Elzayat³

et al. 2017

JCTI

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Background: Pediatric ovarian tumors are rare. The aim of this work is to study the epidemiological characteristics and treatment outcome of these tumors in our locality. Methods: This retrospective study was performed in accordance with the ethical policies. Between January 2011 to December 2015, Thirteen cases of pediatric ovarian cancers were recorded in the Pediatric Oncology Unit of Oncology Center of Mansoura University and the Clinical Oncology & Nuclear Medicine Department of Mansoura University Hospital. The clinico-epidemiologic data and the treatment protocols were analyzed. Results: The median age was 10 years (range: 2-17). Presenting symptoms were mainly lower abdominal pain (6; 46.2%) and palpable abdominal mass (4; 30.7). Through laparotomy all patients underwent unilateral salpingo-oophorectomy except one case for whom bilateral salpingiooophorectomy was done. Six patients were stage I (46.2%), 2 patients were stage II (15.4%) and 5 patients were stage III tumors (38.4%). The majority had germ cell tumors (11; 85%). Adjuvant chemotherapy was given to all cases. Further chemotherapy was needed in 6 cases due to progression or recurrence. The median follow up was 35 months while the median overall survival was 40 months. Mortality rates were 90% in stages II and III together. The advanced stages and yolk sac pathology had the highest mortality. One of the survived cases got married and delivered a baby. Conclusion: Germ cell tumors are the commonest pediatric malignant ovarian tumors. Multimodality treatment is essential. Fertility preservation should be respected. Our mortality rates are relatively high.

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“…In a recent Tai study of 76 patients, Neeyalavira showed that the most common histology of malignant ovarian germ cell tumors was immature teratomas (34.2%). Nevertheless according to Smith, rates for immature teratomas are higher for Asian/Pacific Islanders and Hispanics than Caucasians [12,13]. More specifically, immature formations of teratomas are classified into three categories: firstly, lesions that include immature ectodermic tissue and neuroectodermal epithel in rosettes and tubules, secondly, masses that contain immature mesenchyme with immature cartilage, immature fat, osteoids and rhabdomyoblasts and finally immature endodermal tissue as well as hepatic tissue, intestinal type epithel with basal vacuolization and embryonic renal tissue [1].…”

Section: Discussionmentioning

confidence: 99%

Immature Ovarian Teratoma in a 21 Year –Old Woman: A Case Report and Review of the Literature.

Stavrou¹

2015

J Gen Pract

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with specific tumor markers .So, tumor markers Ca 15-3, Ca19-9, Ca 125, and CEA were fluctuated in normal ranges. Serum levels of alphafetoprotein (a-FP) were significantly elevated reaching the plateau of 392 iu/ ml (normal ranges: <9.5 iu/ml), supporting the sonographically evoked opinion of underlying malignancy. Except that AST (62 IU/L), ALT (73 IU/L) and LDH (309 IU/L) were mildly increased.Because of the young profile of the patient, MRI of upper and lower abdomen has been also performed; similarly to ultrasonographic report, MRI noticed the presence of excessive ascites; it also described a heterogeneous right ovarian mass of 88 × 81 × 100 mm presenting cystic, solid and hemorrhagic contents, fixed to the broad ligament of the uterus. It also revealed 2 thin walled cysts of 4, 3 cm and 2, 4 cm in the left ovary without solid parts. Intraperitoneal tissue in the region of upper abdomen was described, implying the possibility of underlying peritoneal carcinomatosis. The liver, the biliary system, the spleen, the pancreas and the adrenals were normal. MRI didn't reveal enlarged paraaortic, mesenteric, iliac or inguinal lymph nodes (Figure 2). Chest X-ray and ultrasonographically breast examination were normal. Initially, ascites suction was realized in order to alleviate from pressing symptoms. In the operation theater under general anesthesia, laparoscopy was performed with the technique of the four ports for better abdominal exploration in the overweight patient; 4 to 5 liters of ascites were aspirated for cytological examination. The organs of the upper abdomen were normal, without implantations in the peritoneum or omental disease. The uterus and the left adnexa were normal but a mass 10-12 cm of right ovary characterized by abnormal surface was revealed. So exploratory laparotomy followed with vertical incision .Then the cystic lesion was removed and sent for frozen section. The rapid biopsy was positive for

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Outcomes of Malignant Ovarian Germ-Cell Tumors Treated in Chiang Mai University Hospital over a Nine Year Period

Cited by 16 publications

References 12 publications

Choriocarcionoma in an Infantile Patient

Choriocarcionoma in an Infantile Patient

Pediatric and Adolescent Malignant Ovarian Tumors: Mansoura 5 - Year Experience

Immature Ovarian Teratoma in a 21 Year –Old Woman: A Case Report and Review of the Literature.

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