Outcomes of Mass Screening for Gastric Carcinoma

Kunisaki, Chikara; Ishino, Junko; Nakajima, Susumu; Motohashi, Hisahiko; Akiyama, Hirotoshi; Nomura, Masato; Matsuda, Goro; Otsuka, Yuichi; Ono, Hideki; Shimada, Hiroshi

doi:10.1245/aso.2006.04.028

Cited by 66 publications

(52 citation statements)

References 14 publications

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“…Stage-specific survival was applied differently according to the receipt of treatment. When the person did not undergo treatment due to undetected gastric cancer, his or her mortality was decided by the stage-specific survival rate in the unscreened population from the published data (Babazono & Hillman, 1995;Kubota et al, 2000;Kunisaki et al, 2006). The treatment costs of gastric cancer were determined according to the cancer stage.…”

Section: Major Assumptionsmentioning

confidence: 99%

“…Mortality according to age and gender was assessed using National Statistical Office 2008 data (Korea National Statistical Office, 2010). The stage distribution and the survival outcomes in the unscreened population were projected on the basis of local studies (Hansson et al, 1999;Kubota et al, 2000;Dan et al, 2006;Kunisaki et al, 2006;Miyamoto et al, 2007;Nam et al, 2009). The corresponding outcomes for the screened population were projected from clinical studies conducted in Korea or Japan (Kubota et al, 2000;Han et al, 2003;Nam et al, 2009).…”

Section: Incidence and Prevalence Ratesmentioning

confidence: 99%

“…In South Korea, the age standardized incidence of gastric cancer is 65.7 per 100,000 people for men and 26.0 per 100,000 people for women, which are among the world's highest incidences (Shin et al, 2007). The 5-year survival rate of early gastric cancer (EGC) exceeds 90% (Kunisaki et al, 2006), but that of metastatic cancer is less than 5% . Therefore, the early detection and treatment of gastric cancer are important priorities.…”

Section: Introductionmentioning

confidence: 99%

“…The quality of life according to gastric cancer stage was obtained from several published articles (Dan et al, 2006;Hanmer et al, 2006). The survival rate according to stage was calculated using the 5-or 10-year survival rates from a synthesis of published studies (Babazono & Hillman, 1995;Kim et al, 2000;Kunisaki et al, 2006;Miyamoto et al, 2007).…”

mentioning

confidence: 99%

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Comparing Endoscopy and Upper Gastrointestinal X-ray for Gastric Cancer Screening in South Korea: A Cost-utility Analysis

Chang

Park

Chung

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: There are limited data evaluating the cost-effectiveness of gastric cancer screening using endoscopy or upper gastrointestinal x-ray in the general population. Objective: To evaluate the costeffectiveness of population-based screening for gastric cancer in South Korea by decision analysis. Methods: A time-dependent Markov model for gastric cancer was constructed for healthy adults 30 years of age and older, and a deterministic sensitivity analysis was performed. Cost-utility analysis with multiple strategies was conducted to compare the costs and effects of 13 different screening alternatives with respect to the following eligibility criteria: age at the beginning of screening, screening interval, and screening method. The main outcome measurement was the incremental cost-effectiveness ratio. Results: The results revealed that annual endoscopic screening from ages 50-80 was the most cost-effective for the male population. In the females, biennial endoscopy screening from ages 50-80 was calculated as the most cost-effective strategy among the 12 screening alternatives. The most cost-effective screening strategy may be adjustable according to the screening costs and the distribution of cancer stage at screening. The limitation was that effectiveness data were obtained from published sources. Conclusions: Using the threshold of $19,162 per quality-adjusted life year on the basis of the Korean gross domestic product (2008), as suggested by the World Health Organization, endoscopic gastric cancer screening starting at the age of 50 years was highly cost-effective in the Korean population. The national recommendation for gastric cancer screening should consider the starting age of screening, the screening interval, and the screening modality.

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Section: Major Assumptionsmentioning

confidence: 99%

Section: Incidence and Prevalence Ratesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Comparing Endoscopy and Upper Gastrointestinal X-ray for Gastric Cancer Screening in South Korea: A Cost-utility Analysis

Chang

Park

Chung

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…However, considering the mean age of the subjects in this RCT, the rate may not be so high compared to the number of Japanese citizens in their 60 0 s. In Japan GI X-ray using a barium meal is the method for mass gastric cancer screening and is available to asymptomatic individuals older than 40; this is the established nationwide program [8]. Upon positive findings in the barium meal examination [30] further investigation with GIE is recommended. However, the actual participation rate among eligible individuals is only around 20 percent [31].…”

Section: Discussionmentioning

confidence: 99%

Randomized controlled trial comparing gastric cancer screening by gastrointestinal X-ray with serology for Helicobacter pylori and pepsinogens followed by gastrointestinal endoscopy

et al. 2014

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Background Based on the results of several case-control and cohort studies gastrointestinal X-ray (GI X-ray) has been recommended for use in the nationwide screening program for gastric cancer.. Although this was the only effective screening program when almost all of the Japanese population were Helicobacter pylori (H. pylori) positive, there has been concern whether an alternative effective screening system should be established for the future H. pylori-negative generation. We therefore conducted the first randomized controlled trial (RCT) comparing GI X-ray and gastrointestinal endoscopy (GIE) scheduled according to results of serological testing (ST); this was done to determine the potential for an alternative screening method. Methods Subjects who fulfilled the inclusion criteria were residents between the ages of 30 and 74 and who were able to receive gastric cancer screening in the Yurihonjo area. Participants were assigned to the GI X-ray group or the GIE-ST group by computer randomization. Subjects in each group were further subdivided into 4 categories according to their different risks for gastric cancer. The feasibility of stratified randomization was serologically assessed and detection rates of gastric cancer at entry by the different screening methods were also compared. Results Of the 2,962 subjects invited, 1,206 individuals (41 percent) were included in the first stage of this stratified RCT, and 604 and 602 individuals were assigned to the GI X-ray group and the GIE-ST group, respectively. There were no statistically significant differences in sex, age, height, body weight, smoking, alcohol intake and family history of cancer between the 2 groups. During ST the GI X-ray group showed a distribution that was not statistically different from that of the GIE-ST group. Although 3 cases of gastric cancer were detected in the GIE-ST group, there was no statistically significant difference between the 2 groups. One complication found was barium aspiration during the examination in the X-ray group. Conclusion We confirmed that baseline demographic features of the 2 groups were well balanced. We are now organizing the first RCT to compare the existing screening method and the alternative method (Clinical trial registration number: UMIN000005962).Electronic supplementary material The online version of this article

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Quality of life comparison between esophagogastrostomy and double tract reconstruction for proximal gastrectomy assessed by Postgastrectomy Syndrome Assessment Scale (PGSAS)‐45

Ikeda

Takiguchi

Morita

et al. 2022

Annals of Gastroent Surgery

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Aim The current study compared the postoperative quality of life (QOL) between the esophagogastrostomy method (PGEG) and double tract method (PGDT) after proximal gastrectomy using the Postgastretomy Syndrome Assessment Scale (PGSAS)‐45. Methods Among the 2364 patients who received the PGSAS‐45 questionnaire, 300 PGEG and 172 PGDT cases responded. The main outcomes measures (MOMs) consisted of seven subscales (SS) covering symptoms, meals (amount and quality), ability to work, dissatisfaction with daily life, physical and mental component summary of the 8‐Item Short Form Health Survey (SF‐8), and change in body weight, and were compared between PGEG and PGDT. Results Overall, PGDT promoted significantly better constipation SS scores ( p < 0.05), whereas PGEG tended to promote better body weight (BW) loss% ( p < 0.10). A stratified analysis based on the remnant stomach size revealed that among those with a remnant stomach size of 1/2, PGDT had significantly better constipation and dumping SS scores ( p < 0.05) and tended to have better working conditions ( p < 0.10) compared to PGEG. Even among those with the remnant stomach size of 2/3, PGDT had significantly better diarrhea SS scores, lesser dissatisfaction with symptoms, and better dissatisfaction with daily life SS scores ( p < 0.05) and tended to have better constipation SS scores and lesser dissatisfaction with work ( p < 0.10) compared to PGEG. Conclusions After comparing the QOLs of PGEG and PGDT, the stratified analysis according to remnant stomach sizes of 1/2 and 2/3 revealed that PGDT was relatively superior to PGEG for several MOMs.

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Outcomes of Mass Screening for Gastric Carcinoma

Abstract: Mass screening by using barium meal examination for gastric cancer detects cancer at an early stage and produces good therapeutic results.

Cited by 66 publications

References 14 publications

Comparing Endoscopy and Upper Gastrointestinal X-ray for Gastric Cancer Screening in South Korea: A Cost-utility Analysis

Comparing Endoscopy and Upper Gastrointestinal X-ray for Gastric Cancer Screening in South Korea: A Cost-utility Analysis

Randomized controlled trial comparing gastric cancer screening by gastrointestinal X-ray with serology for Helicobacter pylori and pepsinogens followed by gastrointestinal endoscopy

Quality of life comparison between esophagogastrostomy and double tract reconstruction for proximal gastrectomy assessed by Postgastrectomy Syndrome Assessment Scale (PGSAS)‐45

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