Outcomes of Men with Screen-Detected Prostate Cancer Eligible for Active Surveillance Who Were Managed Expectantly

Bergh, Roderick C.N. van den; Roemeling, Stijn; Roobol, Monique J.; Aus, Gunnar; Hugosson, Jonas; Rannikko, Antti; Tammela, Teuvo L.J.; Bangma, Chris H.; Schröder, Fritz H.

doi:10.1016/j.eururo.2008.09.007

Cited by 246 publications

(155 citation statements)

References 27 publications

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“…It is important to note, however, that many patients described in these series were included retrospectively and did not meet the ''strictest'' criteria often used in contemporary AS protocols. Table 2 depicts the reported outcomes from the reviewed AS series [24][25][26][27]. Not unexpectedly-and despite varying entry criteria-the disease-specific and all-cause survival over the short term is high.…”

Section: Criteria For Active Surveillancementioning

confidence: 99%

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Active Surveillance for Prostate Cancer: A Systematic Review of the Literature

et al. 2012

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Please visit www.eu-acme.org/ europeanurology to read and answer questions on-line. The EU-ACME credits will then be attributed automatically. AbstractContext: Prostate cancer (PCa) remains an increasingly common malignancy worldwide. The optimal management of clinically localized, early-stage disease remains unknown, and profound quality of life issues surround PCa interventions. Objective: To systematically summarize the current literature on the management of low-risk PCa with active surveillance (AS), with a focus on patient selection, outcomes, and future research needs.

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Section: Criteria For Active Surveillancementioning

confidence: 99%

“…One of the larger series consists of 988 men, with a median follow-up of 3.91 yr, from the European Randomized Study of Screening for Prostate Cancer (ERSPC) [25]. The authors report an estimated 10-yr PCa-specific survival of 100%, with one patient dying from PCa 11 yr after diagnosis.…”

Section: Criteria For Active Surveillancementioning

confidence: 99%

Active Surveillance for Prostate Cancer: A Systematic Review of the Literature

et al. 2012

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“…Current OnCOlOgy-VOlume 17, Supplement 2 SURVEILLANCE FOR PROSTATE CANCER patients [6][7][8][9][10][11][12][13][14] . Certain observations emerge from these data.…”

Section: S13mentioning

confidence: 99%

“…In most men on prostate cancer surveillance, mortality comes from other causes [2][3][4][5][6][7][8][9][10][11][12][13][14][15] . In the most mature cohort (Toronto), with a median follow up of 8 years, the relative risk for non-prostate-cancer death was 19 times that for prostate cancer mortality.…”

Section: S13mentioning

confidence: 99%

Active Surveillance for Prostate Cancer: Patient Selection and Management

Klotz

2010

Current Oncology

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Screening for prostate cancer using prostate-specific antigen (psa) has been appealing. However, the significant associated decline in prostate cancer mortality comes at the cost of a very high rate of diagnosis, and many patients with indolent, non-life-threatening cancer are exposed to the risk of significant side effects from radical treatment. Most men with favourablerisk prostate cancer are not destined to die of their disease, even in the absence of treatment. The challenge is to identify the subset that harbour more aggressive disease early enough that curative therapy is still a possibility, thereby allowing the others to enjoy improved quality of life, free from the side effects of treatment. This article reviews current research into active surveillance in favourable-risk disease and some of the issues that arise when prostate cancer is monitored rather than being treated immediately.

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“…The distinction is particularly important in that neither oncologic, nor quality of life, outcomes from patients assigned to observation in older randomized trials, [8,14], nor those identified in population-based registries as receiving conservative management, can be considered representative of those expected with contemporary active surveillance. Table 1 summarizes the published prospective experience with active surveillance, comprising more than 2900 patients [15][16][17][18][19][20][21][22][23]. These studies differ in terms of their eligibility and triggers for intervention.…”

Section: Active Surveillance Resultsmentioning

confidence: 99%

Active Surveillance for Low-Risk Prostate Cancer

Klotz

2015

Curr Urol Rep

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Outcomes of Men with Screen-Detected Prostate Cancer Eligible for Active Surveillance Who Were Managed Expectantly

Cited by 246 publications

References 27 publications

Active Surveillance for Prostate Cancer: A Systematic Review of the Literature

Active Surveillance for Prostate Cancer: A Systematic Review of the Literature

Active Surveillance for Prostate Cancer: Patient Selection and Management

Active Surveillance for Low-Risk Prostate Cancer

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