Outcomes of neuroinfections and their predictors

Abstract

Despite the success of vaccine prophylaxis and therapy, neuroinfections remain a serious problem due to the epidemic threat, high mortality and residual disabling and maladaptive neurological deficits in half of the cases.The aim of the literature review was to study modern publications concerning the dynamics of the infectious process in the central nervous system, the nature and predictors of its outcome in children.The results confirmed the effectiveness of social modification with the help of vaccination, guidelines and increased availability of medical care, leading to a decrease in mortality and morbidity of vaccine-controlled neuroinfections. At the same time, the general morbidity and due to the severity of complications and structural acute phase defect post-infectious neurological deficit in the form of epilepsy, motor, cognitive and behavioral disorders remain the same.The study of the outcomes of neuroinfections, their clinic and treatment at all stages, including the remote one, is necessary to develop an optimal protocol for the treatment and rehabilitation of children who have undergone meningitis and encephalitis in order to improve their quality of life.

Clinical features and outcomes of meningitis for children in the republic of North Ossetia–Alania

“…Serous meningitis (SM) in children is now more common than bacterial meningitis; climatic and regional characteristics determine its frequency. Cerebral asthenia, reduced «working memory», hypertonic syndrome, diencephalic syndrome, asthenic-neurotic syndrome, and symptomatic epilepsy develop with serous meningitis during recovery [6]. Analysis of the peculiarities of meningitis development in children can provide important practical information for developing preventive measures in the region.…”