Outcomes of octogenarians undergoing gastrectomy performed for malignancy

Teng, Annabelle; Bellini, Geoffrey; Pettke, Erica; Passeri, Michael; Lee, David Y.; Rose, Keith; Bilchik, Anton J.; Attiyeh, Fadi F.

doi:10.1016/j.jss.2016.08.020

Cited by 13 publications

(19 citation statements)

References 22 publications

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“…In the current study, octogenarians were significantly less likely to have received neoadjuvant therapy, confirming previously published data 32,33 . Despite allowing for patients of any age to be included in the study, the eligibility criteria for the MAGIC trial excluded patients with a creatinine clearance of ≤60 mL/min 6 .…”

Section: Discussionsupporting

confidence: 82%

“…Previous studies have found higher preoperative creatinine levels and preoperative dialysis to be independent predictors of 90‐day mortality and occurrence of major postoperative complications respectively 32,33 . Matsumoto et al 41 showed that patients undergoing gastrectomy for gastric cancer with mild or severe CKD had more postoperative complications, including anastomotic leakages and intraabdominal abscesses, than patients without CKD.…”

Section: Discussionmentioning

confidence: 99%

“…Mortality rates for elderly patients undergoing resection for gastric cancer vary considerably in the literature, ranging from 2% to 10.1% in Asian studies and 3% to 8% in European studies 17‐30 . This inconsistency is corroborated by US studies showing 30 days postoperative mortality rates specifically in octogenarians of 5%, 10.2%, and 7.2% using single‐institutional, multi‐institutional, and ACS‐NSQIP data respectively 31‐33 . In contrast, these studies have established mortality rates ranging from 0% to 4.1% in their younger patients, with conflicting data on whether or not survival differs between elderly and younger patients 17‐24,26,27‐30,32,33 .…”

Section: Introductionmentioning

confidence: 99%

“…[17][18][19][20][21][22][23][24][25][26][27][28][29][30] This inconsistency is corroborated by US studies showing 30 days postoperative mortality rates specifically in octogenarians of 5%, 10.2%, and 7.2% using single-institutional, multi-institutional, and ACS-NSQIP data respectively. [31][32][33] In contrast, these studies have established mortality rates ranging from 0% to 4.1% in their younger patients, with conflicting data on whether or not survival differs between elderly and younger patients. [17][18][19][20][21][22][23][24]26,[27][28][29][30]32,33 Data are similarly conflicting with regards to the outcomes of elderly vs young patients with GE junction tumors undergoing esophagectomy.…”

mentioning

confidence: 99%

“…[31][32][33] In contrast, these studies have established mortality rates ranging from 0% to 4.1% in their younger patients, with conflicting data on whether or not survival differs between elderly and younger patients. [17][18][19][20][21][22][23][24]26,[27][28][29][30]32,33 Data are similarly conflicting with regards to the outcomes of elderly vs young patients with GE junction tumors undergoing esophagectomy. [34][35][36] This study aims to compare perioperative outcomes and survival of patients age 80 or older with younger patients undergoing curative resection for esophagogastric adenocarcinoma at our institution.…”

mentioning

confidence: 99%

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Perioperative outcomes and survival of octogenarians undergoing curative resection for esophagogastric adenocarcinoma

Chen

Senders

Hardacre

et al. 2020

Journal of Surgical Oncology

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Background and Objectives Current data are conflicting as to whether the outcomes of octogenarians undergoing resection for esophagogastric adenocarcinoma are comparable to younger patients. This study aims to compare perioperative outcomes and survival of patients ≥80 years old with younger patients undergoing curative resection for esophagogastric adenocarcinoma. Methods Retrospective data were collected on 190 patients who underwent resection with curative intent for adenocarcinomas found in the stomach and esophagogastric junction from 2004 to 2015 at a single institution. Results Of the 190 patients, 34 (18%) were ≥80 years old. Octogenarians were more likely to have chronic kidney disease (CKD) and were less likely to have received neoadjuvant chemotherapy. Pathologic features were similar between groups. Octogenarians' tumors were more likely to be located in the gastric body as compared to the esophagogastric junction in younger patients. Although the length of stay was comparable, octogenarians were significantly less likely to be discharged home (P < .01). Both groups had a single death during the index admission. Incidence and severity of 90 days postoperative complications were not significantly different between groups. There was no difference in 30‐day, 90‐day, 1‐year, or median survival. Conclusions Perioperative outcomes and survival of octogenarians undergoing curative resection for esophagogastric cancer are comparable to younger patients at our institution.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%