Outcomes of patients hospitalized for acute decompensated heart failure: does nesiritide make a difference?

Abstract

Background: Nesiritide is indicated in the treatment of acute decompensated heart failure. However, a recent meta-analysis reported that nesiritide may be associated with an increased risk of death. Our goal was to evaluate the impact of nesiritide treatment on four outcomes among adults hospitalized for congestive heart failure (CHF) during a three-year period.

Outcomes of Heart Failure-Related Hospitalization in Adults with Congenital Heart Disease in the United States

“…More children are surviving into adulthood with lesions that would have led to their death in childhood a few decades ago . However, a significant proportion of these children have significant cardiovascular morbidities, including heart failure, as they enter adulthood …”

“…Heart failure is one of the most common causes for hospitalization in adults with acquired heart disease and is associated with significant morbidity and mortality. The mortality during heart failure–related hospitalization has been reported between 3–13% . Currently, 5.7 million Americans are estimated to have heart failure, and up to 30% of people who have heart failure die within 1 year from diagnosis .…”

“…The mortality during heart failure-related hospitalization has been reported between 3-13%. [1][2][3] Currently, 5.7 million Americans are estimated to have heart failure, and up to 30% of people who have heart failure die within 1 year from diagnosis. 4,5 As more children with congenital heart disease are surviving into adulthood, the prevalence of heart failure in this group is increasing.…”

Impact of Nesiritide on Renal Function and Mortality in Patients Suffering from Heart Failure

“…The data were extracted [31]. Moreover, in a large study published in 2007 by Carroll and coworkers, there was no statistically significant correlation between infusion of nesiritide and in-hospital mortality [33]. Recently, early initiation of intravenous nesiritide was tested in heart failure patients presenting to the emergency department and who remained symptomatic despite maximal standard therapy (delivered for at least 1 h).…”

Accuracy of the All Patient Refined Diagnosis Related Groups Classification System in Congenital Heart Surgery

“…Previous studies have illustrated problems with case ascertainment in administrative datasets [4-8]. The All Patient Refined Diagnosis Related Groups (APR-DRG) diagnostic classification system is employed in many large pediatric administrative databases, which are often used in clinical research [9-14]. The APR-DRG system is a classification system developed by a third party company and widely used by many hospital administrators and reimbursement entities to evaluate the severity of illness and risk of mortality across all patients admitted for inpatient care for the purpose of reimbursement and financial planning.…”