Outcomes of Patients With Metastatic Anal Cancer According to HIV Infection: A Multicenter Study by the Latin American Gastrointestinal Oncology Group (SLAGO)

Mattos, Bruna Raphaeli Silva; Camandaroba, Marcos Pedro Guedes; Ruiz‐García, Erika; Díaz-Romero, Consuelo; Luca, Romina; Méndez, Guillermo; Lustosa, I.K.F.; Silva, Sinara F.; Mello, Celso Abdon Lopes de; Silva, Virgilio S.; O’Connor, Juan Manuel; Riechelmann, Rachel P.

doi:10.1016/j.clcc.2021.05.005

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…This is also supported by a multicenter study conducted to look at outcomes of patients with metastatic AC according to HIV status where it was found that patients with metastatic AC who are HIV-positive on ART had similar outcomes to those without HIV. 20 …”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Characteristics and Outcomes of Anal Squamous Cell Carcinoma Patients With and Without HIV Infection in Sub-Saharan Africa

Mduma

Dharsee

Samwel

et al. 2023

JCO Global Oncology

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PURPOSE In the past 20 years, the burden of anal cancer (AC) increased by 60% in the United States and over three-fold in Africa. Rates of AC have increased by 20× in people living with HIV and the highest (50×) in men with HIV who have sex with men. However, in sub-Saharan Africa (SSA) where HIV is endemic, data on clinicopathological characteristics and outcomes of patients with AC are lacking. To address this, we have investigated AC disease presentation, treatment outcomes, and its predictors in a cohort of patients who were either HIV-infected or HIV-uninfected in SSA. METHODS We conducted a retrospective cohort study of patients with anal squamous cell carcinoma (SCC) treated at Ocean Road Cancer Institute in Dar es Salaam, Tanzania from January 2014 to December 2019. Associations between the study outcomes and their predictors were analyzed using univariate and multivariate analysis models. RESULTS A total of 59 patients with anal SCC were retrieved and had at least 2-year follow-up. The mean age was 53.9 (standard deviation ±10.5) years. While none of the patients presented with stage I disease, 64.4% had locally advanced disease. HIV infection was the major comorbidity (64.4%). The rate of complete remission at the end of treatment was at 49% while the 2-year overall survival (OS) and local recurrence-free survival were 86.4% and 91.3%, respectively. Despite high HIV coinfection in the cohort, AC treatment outcomes were not significantly associated with HIV status. Disease stage ( P = .012) and grade ( P = .030) were significantly associated with 2-year OS. CONCLUSION Patients with anal SCC in Tanzania present mainly with locally advanced disease associated with high HIV prevalence. In this cohort, the SCC grade was independently associated with treatment outcomes unlike other factors such as HIV coinfection.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological Characteristics and Outcomes of Anal Squamous Cell Carcinoma Patients With and Without HIV Infection in Sub-Saharan Africa

Mduma

Dharsee

Samwel

et al. 2023

JCO Global Oncology

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“…A retrospective analysis of HIV-positive patients on antiretroviral therapy with metastatic SCAC receiving different lines of therapy had outcomes similar to those of patients who are HIV negative. 54 The inclusion of patients who are HIV positive in POD1UM-202 was important, as this provides valuable information for clinical decision making in this group of patients who are at particularly high-risk for SCAC yet have historically been understudied in and/or excluded from clinical trials. 55 In this study, we aimed to determine meaningful biomarkers to allow identification of patients most likely to respond to retifanlimab.…”

Section: Discussionmentioning

confidence: 99%

A phase II study of retifanlimab (INCMGA00012) in patients with squamous carcinoma of the anal canal who have progressed following platinum-based chemotherapy (POD1UM-202)

Anandappa

Capdevila³

et al. 2022

ESMO Open

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“…Racial, gender and socioeconomic status disparities have been documented in this setting, and hence collaborative initiatives should be promoted to dissect causation, mitigate the impact and suggest potential operative solutions [ 41 , 42 ]. Similarly, for the subpopulation of HIV-positive ASCC patients, few clinical data are available highlighting the need for collaborative initiatives to fill the gap, such as the ACTION HIV lead by researchers in Brazil, to establish a global registry to collect clinical data and report on treatment outcomes in HIV ASCC patients [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

A Machine-Learning-Based Bibliometric Analysis of the Scientific Literature on Anal Cancer

Franco

Segelov

Johnsson

et al. 2022

Cancers

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Squamous-cell carcinoma of the anus (ASCC) is a rare disease. Barriers have been encountered to conduct clinical and translational research in this setting. Despite this, ASCC has been a prime example of collaboration amongst researchers. We performed a bibliometric analysis of ASCC-related literature of the last 20 years, exploring common patterns in research, tracking collaboration and identifying gaps. The electronic Scopus database was searched using the keywords “anal cancer”, to include manuscripts published in English, between 2000 and 2020. Data analysis was performed using R-Studio 0.98.1091 software. A machine-learning bibliometric method was applied. The bibliometrix R package was used. A total of 2322 scientific documents was found. The average annual growth rate in publication was around 40% during 2000–2020. The five most productive countries were United States of America (USA), United Kingdom (UK), France, Italy and Australia. The USA and UK had the greatest link strength of international collaboration (22.6% and 19.0%). Two main clusters of keywords for published research were identified: (a) prevention and screening and (b) overall management. Emerging topics included imaging, biomarkers and patient-reported outcomes. Further efforts are required to increase collaboration and funding to sustain future research in the setting of ASCC.

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Outcomes of Patients With Metastatic Anal Cancer According to HIV Infection: A Multicenter Study by the Latin American Gastrointestinal Oncology Group (SLAGO)

Cited by 4 publications

References 20 publications

Clinicopathological Characteristics and Outcomes of Anal Squamous Cell Carcinoma Patients With and Without HIV Infection in Sub-Saharan Africa

Clinicopathological Characteristics and Outcomes of Anal Squamous Cell Carcinoma Patients With and Without HIV Infection in Sub-Saharan Africa

A phase II study of retifanlimab (INCMGA00012) in patients with squamous carcinoma of the anal canal who have progressed following platinum-based chemotherapy (POD1UM-202)

A Machine-Learning-Based Bibliometric Analysis of the Scientific Literature on Anal Cancer

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