Outcomes of Pediatric Oncology Patients Admitted to An Intensive Care Unit in a Resource-limited Setting

Abstract

Background: Improved survival and intensified treatment protocols in pediatric oncology have resulted in an increased need for intensive care. However, in resource-constrained settings, the higher morbidity and mortality of these patients raises sensitive issues around the optimal use of limited critical care resources.Methods: Single-center, 10-year retrospective review of pediatric oncology patients admitted to the pediatric intensive care unit (PICU).Results: Of the 117 admissions, 70.1% had solid tumors, 61.5% were admitted electively, and 76.1% were admitted for noninfective indications. PICU mortality of oncology patients was 18.8% relative to the PICU mortality of all patients in the same period of 10.5%. In a multivariable analysis, factors shown to be independently associated with PICU mortality were infective indications for admission (relative risk = 3.83, confidence interval: 1.16; 12.6, P = 0.028) and vasoactive support (relative risk = 7.50, confidence interval: 1.72; 32.8, P = 0.0074). Conclusion:The increased mortality associated with sepsis, organ dysfunction and need for organ support underscores the need for earlier recognition of and intervention in pediatric oncology patients requiring intensive care. Further prospective studies are needed to identify the most critical areas for improvement in the referral of these children to PICU, to optimize care and improve outcomes.