Outcomes of Percutaneous Coronary Intervention Performed With or Without Preprocedural Dual Antiplatelet Therapy

Ikegami, Yasuyuki; Kohsaka, Shun; Matsubara, Hiroaki; Ueda, Ikuko; Fuse, Jun; Sakamoto, Munehisa; Numasawa, Yohei; Negishi, Koji; Nakamura, Iwao; Maekawa, Yuichiro; Momiyama, Yukihiko; Fukuda, Keiichi

doi:10.1253/circj.cj-15-0484

Cited by 9 publications

(6 citation statements)

References 34 publications

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“…The Japan Cardiovascular Database (JCD) Keio interhospital Cardiovascular Study (KiCS) is a large, ongoing, prospective multicenter cohort study designed to record the clinical background and outcome data of PCI patients in Japan [24][25][26][27][28][29][30][31]. Major teaching hospitals within the metropolitan Tokyo area were selected (15 institutions).…”

Section: Methodsmentioning

confidence: 99%

Incidence and predictors of bleeding complications after percutaneous coronary intervention

Numasawa

Kohsaka

Ueda

et al. 2017

Journal of Cardiology

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Section: Methodsmentioning

confidence: 99%

Incidence and predictors of bleeding complications after percutaneous coronary intervention

Numasawa

Kohsaka

Ueda

et al. 2017

Journal of Cardiology

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“…Despite improvements in treatment, it remains the leading cause of death in STEMI patients. 26, 27 Patients with a decrease in blood pressure and an increase in heart rate are at risk of developing cardiogenic shock. The shock index is an accurate and easily assessable risk marker at the time of initial evaluation, which combines the information of systolic blood pressure and heart rate.…”

Section: Shock Index and Clinical Outcomementioning

confidence: 99%

Shock Index as a Predictor of Myocardial Damage and Clinical Outcome in ST-Elevation Myocardial Infarction

Reinstadler

Fuernau

Eitel

et al. 2016

Circ J

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Background: Data on the prognostic value of the shock index in patients with ST-elevation myocardial infarction (STEMI) are scarce. Furthermore, the relationship of the shock index with myocardial damage is unknown. The aim of this study was to evaluate the association of the shock index with markers of myocardial damage and clinical outcome in patients with STEMI. Methods and Results:This multicenter study analyzed 791 patients. Patients were categorized in 2 groups according to the admission shock index (optimized cut-off=0.62). Infarct severity was determined by cardiac magnetic resonance (CMR) imaging. Patients with cardiogenic shock that were unable to undergo CMR acquisition were excluded. Major adverse cardiac events (MACE) were defined as a composite of death, reinfarction and congestive heart failure within 12 months. Patients with elevated admission shock index (n=321 [40.6%]) had a significantly larger area-at-risk (37. Conclusions: STEMI patients with an elevated admission shock index had more pronounced myocardial and microvascular damage. Moreover, the shock index was independently associated with MACE at 12 months. (Circ J 2016; 80: 924 -930)

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“…[27] In this study, numerically higher rates of bleeding events were observed in the > 12-month group compared to ≤ 12-month group, but the differences between the two groups were not statistically significant. Larger registry data or randomized trial is needed to evaluate clinical relevance.…”

Section: Discussionmentioning

confidence: 62%

Duration of dual antiplatelet therapy in patients treated with percutaneous coronary intervention for coronary chronic total occlusion

et al. 2017

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BackgroundThe duration of dual antiplatelet therapy (DAPT) after drug-eluting stent implantation in coronary chronic total occlusion (CTO) remains unclear.MethodsWe retrospectively analyzed a total of 512 patients treated with percutaneous coronary intervention (PCI) in the Samsung Medical Center CTO registry. Patients were separated into ≤ 12-month (199, 38.9%) vs. > 12 month (313, 61.1%) based on DAPT duration with aspirin and clopidogrel. The primary outcome was major adverse cardiac and cerebrovascular event (MACCE) during follow-up.ResultsMedian follow-up duration was 67 (interquartile range: 51–84) months. MACCE occurred in 43 patients (21.6%) in the ≤ 12-month and 55 patients (17.6%) in the > 12-month groups. In the propensity-matched population, the rate of MACCE did not differ significantly between the ≤ 12-month and > 12-month group (19.4% vs. 18.8%; hazard ratio [HR], 0.95; 95% confidential interval [CI], 0.52–1.76, p = 0.88). Moreover, moderate or severe bleeding according to BARC criteria (type 2, 3 or 5) was also similar between the ≤ 12-month and > 12-month group (2.5% vs. 1.9%; HR, 1.00; 95% CI, 0.20–4.96, p = 0.99).ConclusionAmong patients treated with PCI for CTO, DAPT with durations of ≤ 12-month showed similar long-term clinical outcomes compared to > 12-month DAPT.

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Outcomes of Percutaneous Coronary Intervention Performed With or Without Preprocedural Dual Antiplatelet Therapy

Cited by 9 publications

References 34 publications

Incidence and predictors of bleeding complications after percutaneous coronary intervention

Incidence and predictors of bleeding complications after percutaneous coronary intervention

Shock Index as a Predictor of Myocardial Damage and Clinical Outcome in ST-Elevation Myocardial Infarction

Duration of dual antiplatelet therapy in patients treated with percutaneous coronary intervention for coronary chronic total occlusion

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