Outcomes of polytetrafluoroethylene-covered stent versus bare-metal stent in the primary treatment of severe iliac artery obstructive lesions

Piazza, Michele; Squizzato, Francesco; Spolverato, Gaya; Milan, Luca; Bonvini, Stefano; Menegolo, Mirko; Grego, Franco; Antonello, Michele

doi:10.1016/j.jvs.2015.05.028

Cited by 50 publications

(45 citation statements)

References 14 publications

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“…The COBEST is the only randomised controlled trial comparing the use of CS and BMS for complex lesions classified by the TASC II as class C and D. In this study, there was a significantly better patency in favour of CS both at 1 year 6 and at 5 years. 7 Recently it was reported, 8 in a single centre experience, that the use of a CS rather than a BMS has better early and midterm outcomes in cases of TASC D lesions with long segment severe stenosis involving both the common iliac artery (CIA) and the external iliac artery (EIA). However, no previous studies have focused on the outcomes of CS versus BMS in the primary treatment of IAOs only.…”

Section: Introductionmentioning

confidence: 99%

Editor's Choice – Outcomes of Self Expanding PTFE Covered Stent Versus Bare Metal Stent for Chronic Iliac Artery Occlusion in Matched Cohorts Using Propensity Score Modelling

Piazza

Squizzato

Dall’Antonia

et al. 2017

European Journal of Vascular and Endovascular Surgery

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Overall, the use of self expanding CS for IAOs has similar early and midterm outcomes compared with BMS. Even if further confirmatory studies are needed, CSs seem to have higher midterm patency rates than BMSs for TASC D lesions, IAOs with a total lesion length > 6 cm, occlusion length > 3.5 cm, and calcification involving > 75% of the arterial wall circumference. These specific anatomical parameters may be useful to the operator when deciding between CS and BMS during endovascular planning.

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Section: Introductionmentioning

confidence: 99%

Editor's Choice – Outcomes of Self Expanding PTFE Covered Stent Versus Bare Metal Stent for Chronic Iliac Artery Occlusion in Matched Cohorts Using Propensity Score Modelling

Piazza

Squizzato

Dall’Antonia

et al. 2017

European Journal of Vascular and Endovascular Surgery

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“…major amputation, renal failure and death) and poor long-term durability [5][6][7][8] . There is great interest in developing novel medical therapies for the leg symptoms of PAD.…”

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confidence: 99%

Development of a two-stage limb ischemia model to better simulate human peripheral artery disease

Krishna

Omer

et al. 2020

Sci Rep

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peripheral arterial disease (pAD) develops due to the narrowing or blockage of arteries supplying blood to the lower limbs. Surgical and endovascular interventions are the main treatments for advanced pAD but alternative and adjunctive medical therapies are needed. currently the main preclinical experimental model employed in pAD research is based on induction of acute hind limb ischemia (HLI) by a 1-stage procedure. Since there are concerns regarding the ability to translate findings from this animal model to patients, we aimed to develop a novel clinically relevant animal model of pAD. HLi was induced in male Apolipoprotein e (ApoE −/− ) deficient mice by a 2-stage procedure of initial gradual femoral artery occlusion by ameroid constrictors for 14 days and subsequent excision of the femoral artery. This 2-stage HLI model was compared to the classical 1-stage HLI model and sham controls. ischemia severity was assessed using Laser Doppler perfusion imaging (LDpi). Ambulatory ability was assessed using an open field test, a treadmill test and using established scoring scales. Molecular markers of angiogenesis and shear stress were assessed within gastrocnemius muscle tissue samples using quantitative polymerase chain reaction. HLI was more severe in mice receiving the 2-stage compared to the 1-stage ischemia induction procedure as assessed by LDPI (p = 0.014), and reflected in a higher ischemic score (p = 0.004) and lower average distance travelled on a treadmill test (p = 0.045). Mice undergoing the 2-stage HLI also had lower expression of angiogenesis markers (vascular endothelial growth factor, p = 0.004; vascular endothelial growth factor-receptor 2, p = 0.008) and shear stress response mechano-transducer transient receptor potential vanilloid 4 (p = 0.041) within gastrocnemius muscle samples, compared to animals having the 1-stage HLI procedure. Mice subjected to the 2-stage HLI receiving an exercise program showed significantly greater improvement in their ambulatory ability on a treadmill test than a sedentary control group. this study describes a novel model of HLi which leads to more severe and sustained ischemia than the conventionally used model. Exercise therapy, which has established efficacy in PAD patients, was also effective in this new model. this new model maybe useful in the evaluation of potential novel pAD therapies.Peripheral arterial disease (PAD) leads to impaired lower limb blood supply usually as a result of atherosclerosis and associated thrombosis 1 . In 2010 an estimated 200 million people worldwide were living with PAD, an increase of ~30% since 2000 which has been referred to as a PAD pandemic 2,3 . The burden of PAD is increasing worldwide and particularly within low and middle-income countries 4 . PAD is associated with significant morbidity including intense leg pain during walking (intermittent claudication, IC), impaired walking ability, poor health-related quality of life and risk of serious complications such as major leg amputation and death 1 . Medical management of PAD is ...

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“…Interestingly, in a study by Humphries et al 7 in 2014 looking strictly at percutaneous iliac artery interventions, the use of covered balloon-expandable stents conferred a reduction in patency rates compared with bare-metal balloon-expandable stents. In two separate series by Piazza et al 8 and Psacharopulo et al, 9 it was demonstrated that covered stents for severe iliac lesions had patency rates similar to those of bare-metal stents. However, when both of these groups of investigators looked specifically at long-segment TASC D lesions, covered stents actually had better patency rates than baremetal stents in this subgroup of patients.…”

Section: Discussionmentioning

confidence: 96%

Patency and limb salvage after femoral endarterectomy and iliac stenting are not affected by severity of iliac disease

Ilano

Garvin

Ryer

et al. 2017

Journal of Vascular Surgery

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Outcomes of polytetrafluoroethylene-covered stent versus bare-metal stent in the primary treatment of severe iliac artery obstructive lesions

Abstract: Overall, the use of CSs for severe iliac lesions has similar early and midterm outcomes compared with BMS. In a subcategory of TASC II D lesions with long-segment severe stenosis of both the common and external iliac arteries, CS should be considered as the primary line of treatment.

Cited by 50 publications

References 14 publications

Editor's Choice – Outcomes of Self Expanding PTFE Covered Stent Versus Bare Metal Stent for Chronic Iliac Artery Occlusion in Matched Cohorts Using Propensity Score Modelling

Editor's Choice – Outcomes of Self Expanding PTFE Covered Stent Versus Bare Metal Stent for Chronic Iliac Artery Occlusion in Matched Cohorts Using Propensity Score Modelling

Development of a two-stage limb ischemia model to better simulate human peripheral artery disease

Patency and limb salvage after femoral endarterectomy and iliac stenting are not affected by severity of iliac disease

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