Outcomes of Postchemoradiotherapy Watch‐and‐Wait Strategy in Patients With Rectal Cancer: A 20‐Year, Single‐Center Study

Abstract

Background and ObjectivesThe watch‐and‐wait (WW) strategy is a nonsurgical alternative for patients with rectal cancer exhibiting an excellent response to chemoradiotherapy. Studies on the WW strategy have primarily investigated 5‐year oncological outcomes; few have focused on longer‐term outcomes or the optimal patient selection approach for this therapeutic strategy.MethodsThis retrospective study enrolled patients with locally advanced rectal adenocarcinoma who had achieved complete response after chemoradiotherapy. Patients who achieved pathological complete response were categorized into a control group (n = 95) and those who achieved clinical complete response and were managed using the WW strategy were categorized into a case group (n = 33). Kaplan–Meier estimates were calculated for the between‐group comparison of survival.ResultsThe median follow‐up duration was 89 months. Compared with the control group, the case group exhibited improved long‐term sphincter preservation, particularly for low‐lying tumors (p = 0.032), and inferior nonlocal‐regrowth disease‐free survival (p = 0.007). Within the case group, patients achieving a complete response by positron emission tomography exhibited 5‐year survival rates similar to those achieving a complete endoscopic response.ConclusionThe WW strategy is associated with improved sphincter preservation but worse nonlocal‐regrowth disease‐free survival. The potential of PET in patient selection for this strategy deserves further investigation.