Outcomes of prenatally diagnosed sacrococcygeal teratomas: the results of a Japanese nationwide survey

Usui, Noriaki; Kitano, Yoshihiro; Sago, Haruhiko; Kanamori, Yutaka; Yoneda, Akihiro; Nakamura, Tomoo; Nosaka, Shunsuke; Saito, Mari; Taguchi, Tomoaki

doi:10.1016/j.jpedsurg.2011.08.020

Cited by 53 publications

(44 citation statements)

References 20 publications

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“…Open fetal surgery with in‐utero resection of the tumor is offered in some centers, but with high maternal and fetal morbidity related to the large uterine incision. Therefore, minimally invasive management has been proposed as an alternative to tumor resection in order to arrest tumor growth and halt or even reverse hydrops. Several minimally invasive techniques have been described: laser ablation, radiofrequency ablation (RFA), thermocoagulation and embolization using a coil or alcohol.…”

Section: Introductionmentioning

confidence: 99%

Technical aspects and effectiveness of percutaneous fetal therapies for large sacrococcygeal teratomas: cohort study and literature review

Sananès

Javadian

Britto

et al. 2016

Ultrasound in Obstet & Gyne

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Section: Introductionmentioning

confidence: 99%

Technical aspects and effectiveness of percutaneous fetal therapies for large sacrococcygeal teratomas: cohort study and literature review

Sananès

Javadian

Britto

et al. 2016

Ultrasound in Obstet & Gyne

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“…Fetal sacrococcygeal teratomas (SCT) occur in 1–2 per 20 000 pregnancies. SCTs presenting postnatally have excellent long‐term outcomes, but the perinatal mortality of prenatally diagnosed SCTs ranges from 25% to 37%. Death occurs mainly in fetuses with fast growing, solid and highly vascularized teratomas, which can cause high‐output cardiac failure.…”

Section: Introductionmentioning

confidence: 99%

Minimally invasive therapy for fetal sacrococcygeal teratoma: case series and systematic review of the literature

Mieghem

Al-Ibrahim

Deprest

et al. 2014

Ultrasound in Obstet & Gyne

103

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“…The relation type between the solid and cystic component of the tumor seems to be, in contrast, predictive for the outcome, as the solid part of the lesion is usually very vascularized, with high growth potential, and increased risk for cardiac failure and hemorrhage. [ 4 5 ] Westerburg et al [6] suggested that the tumor's maximum diameter seemed not to be an independent factor for poor outcome, although no fetuses with tumors less than 10 cm in diameter died. In a study published on 28 cases, Coleman et al [7] reported that faster SCT growth during fetal life is associated with higher mortality, whereas patients with pour outcome and adverse events had an average growth rate 3 to 4 times higher than the ones with positive outcome.…”

Section: Discussionmentioning

confidence: 99%

Hydrocephalus secondary to chemotherapy in a case of prenatally diagnosed giant immature grade 3 sacrococcygeal teratoma

Sârbu¹,

Socolov²,

Socolov³

et al. 2016

Medicine

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Introduction:Sacrococcygeal teratoma (SCT) is a rare tumor in the general population, arising from multipotent stem cells. Whereas most of the cases diagnosed postnatally have good prognosis, the rate of mortality and morbidities associated with prenatally diagnosed SCT remain high, with a reported mortality rate of 30% to 50%. The outcome of fetal SCT can be unpredictable, with some cases with slow growth during fetal life, whereas others grow rapidly, causing multiple complications; also, some of these tumor will develop triggering fetal (preterm delivery, high-output cardiac failure, hydrops fetalis, intrauterine death) or maternal complications (distocia, placentomegaly, maternal mirror syndrome—preeclampsia). Even if prenatal criteria seem to define tumors at risk, it can not totally predict postnatal outcome as treatment-related complications can occur.We present a case of giant prenatally detected SCT. The case was diagnosed at 24th week of gestation, and was closely monitored by serial ultrasound. The morphology of the lesion was defined by fetal MRI performed at 25th week of gestation. A baby girl with a huge sacrococcygeal tumor was born and surgery was performed 48 hours later. Pathological examination revealed a grade 3 immature teratoma. Because of the tumor size and pathological aspect, adjuvant chemotherapy was considered. The outcome was complicated by wound infection, sepsis, and subsequent hydrocephalus, induced by chemotherapy-induced immunosuppression.Conclusion:Our case emphasizes not only the importance of prenatal monitoring of these cases but also the importance of individualized postnatal management, as unusual and unpredictable complications can occur and affect outcome.

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Outcomes of prenatally diagnosed sacrococcygeal teratomas: the results of a Japanese nationwide survey

Cited by 53 publications

References 20 publications

Technical aspects and effectiveness of percutaneous fetal therapies for large sacrococcygeal teratomas: cohort study and literature review

Technical aspects and effectiveness of percutaneous fetal therapies for large sacrococcygeal teratomas: cohort study and literature review

Minimally invasive therapy for fetal sacrococcygeal teratoma: case series and systematic review of the literature

Hydrocephalus secondary to chemotherapy in a case of prenatally diagnosed giant immature grade 3 sacrococcygeal teratoma

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