Outcomes of Primary Colorectal Sarcoma: A National Cancer Data Base (NCDB) Review

Thiels, Cornelius A.; Bergquist, John R.; Krajewski, Adam; Lee, Hee Eun; Mathis, Kellie L.; Habermann, Elizabeth B.; Cima, Robert R.

doi:10.1007/s11605-016-3347-0

Cited by 29 publications

(44 citation statements)

References 14 publications

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“…NCDB is a hospital-based registry from a coalition between the American College of Surgeon's Commission on Cancer and the American Cancer Society that is available after proposal approval for clinical investigators at CoC accredited cancer programs. NCDB provides a large-scale look at the patterns of care for cancer and has been used extensively in the study of several types of cancer [11][12][13] and in neuro-oncology [14,15]. As patients with glioblastoma require specialized care, essentially all of the cases are expected to receive treatment in CoC accredited hospitals, making NCDB the most suitable registry to analyze patterns of care in this population.…”

Section: Methodsmentioning

confidence: 99%

National cancer database analysis of outcomes in pediatric glioblastoma

et al. 2018

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Glioblastoma in children is an aggressive disease with no defined standard therapy. We evaluated hospital‐based demographic and survival patterns obtained through the National Cancer Database to better characterize children with glioblastoma. Our study identified 1173 patients from 0 to 19 years of age between 1998 and 2011. Comparisons were made among demographics, clinical characteristics, treatment, and survival variables. Fifty‐four percent of patients were over 10 years of age. Approximately 80% of patients underwent either partial or complete resection. Adjuvant therapy was used variably, and its use increased with patient age. Forty‐eight percent of patients received the combination of surgery, radiation, and chemotherapy, and 4% did not receive any treatment. As expected, patients ≤5 years of age had better 5‐year survival than those ages 6–10 (P = 0.01) or 11–19 years (P = 0.0077). Other factors associated with poor survival included black race and central tumor location. Better outcomes were associated with treatment that included surgery, radiotherapy, and chemotherapy compared to any other treatment combinations. Radiotherapy had no impact on survival in the 0 to 10‐year‐old age group, but was associated with improved survival for patients 11–19 years. We report an extensive demographic and survival analysis of pediatric glioblastoma. The observed differences likely reflect variances in tumor biology and likelihood of treatment receipt. Improved survival was associated with the use of surgery, radiotherapy, and chemotherapy. Radiation therapy was not associated with survival in patients younger than 10 years of age.

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Section: Methodsmentioning

confidence: 99%

National cancer database analysis of outcomes in pediatric glioblastoma

et al. 2018

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“…Only a few cases of the LMS of colon have so far been reported. However, LMS accounted for 57.5% of a series of 433 patients with primary colorectal sarcoma reported between 1998 and 2012 in the National Cancer Data Base, USA by Thiels et al [ 6 ] There are a few studies that defined the outcome of primary LMS patients alone. Grade and size are the most important prognostic factors for disease-specific survival and distant recurrence in patients with primary LMS.…”

Section: Discussionmentioning

confidence: 99%

Primary leiomyosarcoma in the colon

Yang

2018

Medicine

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Rationale:Leiomyosarcoma (LMS) is a common type of soft tissue sarcoma. Primary colonic LMS in general is a very rare entity, accounting for 1% to 2% of gastrointestinal malignancies.Patient concerns:We report a case of 55-year-old female who presented with a sudden onset of sharp right lower quadrant abdominal pain. Electronic colonoscopy showed a normal lumen. However, an abdominal computed tomography scan revealed a mass of soft tissue attenuation inseparable from the ascending colon which appeared as a gastrointestinal stromal tumor (GIST).Diagnoses:It is important to diagnose LMS definitively by immunohistochemical profiling of smooth muscle actin, desmin, and CD34.Interventions:She underwent laparotomy and right hemicolectomy, and histology confirmed a colonic LMS. The patient received no oncological treatment after surgery.Outcomes:No recurrence or metastasis was observed at 5 months postoperatively. It is crucial to identify colonic LMS precisely based on immunohistochemistry, and thereby distinguish it from GIST.Lessons:Further investigation on LMS cases so far is required to establish standard treatment strategies.

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“…In addition, increasing the physical activity may help in reducing the risk of developing cancer. Further long term smokers and alcohol users are more prone to colorectal cancers 7,8 .…”

Section: Avoidable Risk Factorsmentioning

confidence: 99%

Colorectal Cancer: A Review of Disease Diagnosis, Surgical Intervention and Treatment Procedures

Ramesh¹,

Dsouza²,

Yogish.³

et al. 2018

IRJPS

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Colorectal cancer, also known as bowel or colon cancer is associated with colon or rectum sections of the intestine. Globally, more than 1 million people are affected by colorectal cancer every year and have been the cause for death in about 715,000 in 2010. As of 2012, it is the second most common cause of cancer in women (9.2% of diagnoses) and the third most common in men (10.0%). It also accounts for the fourth most common cause of cancer death after lung, stomach, and liver cancer. Colorectal cancer develops mostly during aging and as a reason of increasing lifestyle disorders as well as rarely through genetic heredity. Hence, this grows immense interest in the diagnosis, cure, genetic counseling and general awareness about the disease. Surgery, chemotherapy and radiation therapy, either individually or carried out in conjecture, seems to be the best treatment for the disease. Assessment of risk factors is very important in the early detection of the disease. This review aims to compile broadly the available knowledge on the causes of colorectal cancer, the methods for prevention, therapy or treatment of the disease and the guidelines for genetic counseling and general awareness. It also helps in understanding the risk factors in the development of disease.

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Outcomes of Primary Colorectal Sarcoma: A National Cancer Data Base (NCDB) Review

Abstract: Primary colorectal sarcomas are rare and present at a younger age and higher grade than adenocarcinoma of the colon and rectum. Survival is significantly worse compared to adenocarcinoma patients.

Cited by 29 publications

References 14 publications

National cancer database analysis of outcomes in pediatric glioblastoma

National cancer database analysis of outcomes in pediatric glioblastoma

Primary leiomyosarcoma in the colon

Colorectal Cancer: A Review of Disease Diagnosis, Surgical Intervention and Treatment Procedures

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