Outcomes of Primary Radiosurgery Treatment of Glomus Jugulare Tumors: Systematic Review With Meta-analysis

Abstract

In the short term, PRS is safe and effective at controlling growth and clinical symptoms for patients with GJTs, though there exists significant selection bias, inconsistent reporting, and clinical heterogeneity among existing studies.

Single‐session image‐guided robotic radiosurgery and quality of life for glomus jugulare tumors

“…The recurrence after 5.9 years in one of our patients highlights the fact that GJTs can relapse even after a long follow-up, as discussed in various other studies. 9,17,18,34,35 In addition, GJTs are usually slowly growing tumors with most of them having a tumor doubling time of more than 10 years and an average growth rate of less than 1 mm per year. 36 Subsequently, long follow-up periods are…”

“…8,17 Several studies have investigated the role of radiosurgery in the treatment of GJTs either using single-session or fractionated treatments. 18 Especially the use of Gamma Knife (GK)-and linear accelerator-based radiosurgery were analyzed by different researchers over the past decades and showed good results. 17,[19][20][21][22] Due to the inherent limitations of the stereotactic frame-based radiosurgery, it may not be performed for lower located GJTs.…”

Management of a complex glomus jugulare tumor with severe brainstem compression

“…A postoperative MRI shows a subtotal resection showing an important brainstem decompression, leaving the extradural component of the tumor (De Brito et al, 2018). The residual was treated with radiotherapy (Sahyouni et al, 2018;Shapiro et al, 2018).…”

A Concise Review of Irradiation for Temporal Bone Chemodectomas (TBC)

“…In this context, conventionally fractionated RT and radiosurgery as SRS, FSRT, or HFSRT are now considered as a viable part of multimodality TBC management. While management of advanced, incompletely resected, or recurrent lesions with irradiation has been widely accepted as common practice, accumulating evidence in favor of irradiation has been supported by several studies as well as systemic reviews and metaanalyses assessing its utility as the primary mode of management [56, [63][64][65][73][74][75][76][103][104][105][106][107][108][109][110].…”

“…Negligible doses around the target with radiosurgery allows for respecting the tolerance of critical surrounding structures, leading to an improved toxicity profi le compared to surgery [103,104]. Additional favorable aspects of radiosurgical management may include shortening of overall treatment time with expedited recovery typically as an outpatient procedure, earlier return to daily life, improved functional preservation and quality of life, and cost-effectiveness [1,[103][104][105][106].…”