Outcomes of radiofrequency ablation for anal high-grade squamous intraepithelial lesions

A Prospective, Dual-Center Trial of Circumferential Radiofrequency Ablation of Anal High-Grade Squamous Intraepithelial Lesions Demonstrate Improved Long-term Efficacy Over Historical Controls of Targeted Ablation

“…If participants had recurrent HSIL, then they were retreated with 5 pulses targeting the recurrence. 20 Although innovative, it does not seem that this technique offered improvement over our methodology.…”

“…Ablation of anal HSIL with electrocautery or infrared coagulation (IRC) is probably the mainstay HSIL treatment. [7][8][9][12][13][14][15][16][17][18][19][20][21] Ablative therapies use HRA-guided identification and targeted destruction of individual HSILs. With the hope of diminishing recurrence, we used widefield ablation of the anal canal targeting both identifiable HSIL and seemingly normal The initial trial was small (10 participants) and conducted in single center with only a 12-month follow-up.…”

Treatment of precancerous anal lesions in HIV patients: should they be treated or monitored?

“…Vergara-Fernandez et al [8] studied radiofrequency ablation in the same population group (n = 12), which were young adults (mean age 38 y). At 1-year postintervention, high-resolution anoscopy showed normality in 58.3% of patients, 3 showed recurrence, and 2 showed persistence, which were treated with electrocautery.…”

“…It is necessary to highlight that individuals reported severe pain with radiofrequency ablation. Thus, radiofrequency ablation was shown to be ~60% effective in immunocompromised patients with HSIL [8] . Then, the genotypical and clinicopathologic characteristics of anorectal lesions in HIV patients must be known with precision in order to define the most appropriate, cost-effective, cost-useful behavior [9,10] .…”