Outcomes of radiotherapy in early stage glottic laryngeal carcinoma: a single center experience

Abstract

Our aim was to determine the treatment outcomes and the prognostic factors affecting local control in early stage glottic carcinoma (ESGC) treated with definitive radiotherapy (RT). Between April 2003 and May 2015, 76 patients with ESGC were treated at Inonu University Hospital. There were 58 patients with T1a, 7 T1b and 11 with T2 tumors. Twenty-two patients were treated with conformal radiotherapy, 31 patients were treated with conventional RT and 23 patients were treated with intensity modulated radiotherapy as initial treatment. During a median follow-up of 51 months (range 6-136), 11 patients had failures. Five year overall survival rates were 73.7% in T1 and 81.8% T2. Local control rate was 85.5% in our patients. Patients who were over 61 years had significantly lower local control (p = 0.042). One patient treatment was interrupted because of grade 3 edema. One patient had grade 3 dermatitis, 2 patients grade 3 mucositis and 4 patients grade 3 edema, respectively. Our results suggest that curative radiotherapy is an effective treatment modality in ESGC without increasing toxicity. Age proved to be the only independent prognostic factor affecting local control after primary radiotherapy according to the results of this study.

Predictors of Survival in Patients with Metastatic Brain Tumors: Experience from a Low-to-Middle-Income Country

“…3 However, our results are based on a small sample, and may represent a statistical outlier. Our findings of low median OS and PFS of 6.7 and 6 months, respectively, also corroborated with the literature, where they ranged from 3.4 to 12.8 1 3 8 10 11 12 13 and 6.91 months, 10 respectively.…”

“…Other common primary tumors include malignant melanomas, colon cancer, and sarcomas. 3 7 8 13 15 However, primary systemic disease did not significantly impact survival in our study.…”

“…This can perhaps be explained by significantly better outcomes reported for BM from breast cancer, 1 11 which predominantly occurs in females. While recent literature reported lung tumors as the commonest primary tumors in their patients, 1 7 8 14 15 a major caveat in our series concerns the fact that the most common solid tumor was breast. This may be explained by the fact that most patients presenting to us were female, unlike other studies, which showed males to have a higher incidence of BM.…”

“…Several facets of metastatic brain tumor care remain unexplored. Age, performance status at presentation, presence of extracranial metastases, number of BM, and site of primary tumor 1 2 8 10 11 12 have all been linked to survival in previous studies. However, assessment of these factors in low-middle income patient populations, as well as identification of other static factors and their association with survival indices, is rarely reported.…”

“…Existing literature is usually noted to either evaluate the aforementioned prognostic models or different management strategies, for prognoses and overall survival (OS). 6 7 8 9 However, the interplay of several other static factors such as tumor location, radiologic heterogeneity between patients, postoperative complications, and their effect on the survival outcomes is yet to be studied. Moreover, only limited data from a few centers exist on evaluating the effect of these prognostic models on recurrence or progression of metastatic brain tumors.…”