Outcomes of Sinonasal Squamous Cell Carcinoma with and without Association of Inverted Papilloma: A Multi-Institutional Analysis

Lobo, Brian C.; D’Anza, Brian; Farlow, Janice L.; Tang, Dennis M.; Woodard, Troy D.; Ting, Jonathan Y.; Sindwani, Raj

doi:10.2500/ajra.2017.31.4470

Cited by 28 publications

(47 citation statements)

References 19 publications

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“…No differences in the frequency of NSCLC with EGFR exon 20 insertion mutations have been observed between Asian and Caucasian patients . Additionally, the frequency of clinicopathological ISP‐associated SNSCCs appears to be independent from geographical differences; the frequency has been reported to be 24% and 25% in two large studies including more than 80 patients from United States and South Korea, respectively . Similar to these previous studies, our study, that examined a large cohort of Japanese patients, also identified clinicopathological ISP‐associated SNSCCs in 17 (21%) of 80 SNSCCs.…”

Section: Discussionsupporting

confidence: 85%

Sinonasal squamous cell carcinoma and EGFR mutations: a molecular footprint of a benign lesion

et al. 2018

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Section: Discussionsupporting

confidence: 85%

Sinonasal squamous cell carcinoma and EGFR mutations: a molecular footprint of a benign lesion

et al. 2018

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“…Endoscopy, computed tomography, and magnetic resonance imaging are usually not able to determine whether the SCC arose from the malignant transformation of existing IPs . IP‐associated SCC is most often diagnosed at an advanced stage and has a poor prognosis . In this study, data from a cohort of patients with this unusual sinonasal tumor were analyzed for prognostic factors and survival outcomes.…”

Section: Discussionmentioning

confidence: 99%

Survival outcomes and prognostic factors of squamous cell carcinomas arising from sinonasal inverted papillomas: a retrospective analysis of 120 patients

Wang

et al. 2019

Int Forum Allergy Rhinol

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Background:This study aimed to analyze the prognostic factors and survival outcomes of squamous cell carcinoma (SCC) originating from sinonasal inverted papillomas (IPs), based on data from a single institution. Methods:The data from 120 patients treated at the affiliated Beijing Tongren Hospital, Capital Medical University, for SCC originating from sinonasal IPs between 2005 and 2018 were retrospectively reviewed. Data related to demographic features, tumor characteristics, treatment modality, and clinical outcomes were collected. Survival data were investigated using the Kaplan-Meier method, Cox regression analysis, and the nomogram model predictive of survival probabilities.Results: Among 1034 patients with sinonasal IPs, 120 patients (11.6%) with malignancy were identified. The overall survival (OS) and disease-free survival (DFS) rates at 5 years were 56.0% and 42.3%, respectively. Multivariate analysis showed that synchronous tumors and tumor stage were independent predictive factors for the risk of mortality (hazard ratio [HR], 1.954; 95% confidence interval [CI], 1.022-3.737, p = 0.043; HR, 1.737, 95% CI, 1.095-2.770, p = 0.020, respectively). The surgical margin was another important independent predictor, with patients with negative margins demonstrating a more than 2-fold improved survival compared to those with positive margins (HR, 2.095; 95% CI, 1.031-4.243; p = 0.041). Conclusion:The main factors affecting the prognosis and outcomes were synchronous tumors, advanced tumor stage, and positive surgical margins. These findings highlight the importance of tumor biology and early detection in patient outcomes. In addition, risk factors should be taken into consideration during treatment planning and subsequent tumor surveillance. C 2019 ARS-AAOA, LLC.

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“…The available published studies provided conflicting conclusions. Some reports have shown improved survival outcomes for IP‐SNSCC patients, 6,7 whereas others suggested outcomes similar to those for DN‐SNSCC patients 8,9 …”

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confidence: 99%

Comparison of outcomes between patients with de‐novo sinonasal squamous cell carcinoma vs malignant transformations from inverted papillomas

Quan

Zhang

Zou

et al. 2020

Int Forum Allergy Rhinol

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Background:The survival difference between de-novo sinonasal squamous cell carcinoma (DN-SNSCC) and SCC arising from inverted papillomas (IPs) is unclear. The purpose of this study was to compare the outcomes between DN-SNSCC and IP-transformed SNSCC (IP-SNSCC) patients. Methods:In this retrospective review, we compared IP-SNSCC and DN-SNSCC cases from the Eye and ENT Hospital of Fudan University from 2010 to 2017. A total of 162 patients (39 IP-SNSCC and 123 DN-SNSCC) were included in our study. Demographics, tumor characteristics, treatment, and clinical outcomes were analyzed. Results:The median follow-up time in all cohorts was 56 (range, 5-109) months. There was no difference in age, sex, smoking history, alcohol consumption, tumor primary site, or disease stage between the IP-SNSCC and DN-SNSCC patients. We also did not find significant differences in overall survival and disease-free survival between IP-SNSCC and DN-SNSCC patients (p = 0.584 and p = 0.238, respectively). The 5-year local failure rate was 52.8% for IP-SNSCC patients, which was significantly higher than for those with DN-SNSCC (31.9%; p = 0.013). The 5-year nodal failure rate was 19.0% for IP-SNSCC patients and 8.5% for DN-SNSCC patients (p = 0.211). The 5-year distant metastasis rate was 8.0% for IP-SNSCC patients and 16.1% for DN-SNSCC patients (p = 0.318). Conclusion:IP-SNSCC and DN-SNSCC patients have similar survival outcomes. IP-SNSCC seems to have exhibited a higher local failure rate in our study. We believe that IP-SNSCC is a highly aggressive disease that requires radical treatment. Prophylactic neck treatment should not be omi ed in a subset of IP-SNSCC patients. C 2020 ARS-AAOA, LLC. S. Comparison of outcomes between patients with de-novo sinonasal squamous cell carcinoma vs malignant transformations from inverted papillomas. Int Forum Allergy Rhinol. 2020;10: 762-767.S inonasal malignancies are rare neoplasms, accounting for 3% of head and neck cancers and <1% of all human tumors. 1 The most common histologic type of sinonasal cancer is squamous cell carcinoma (SCC), which accounts

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Outcomes of Sinonasal Squamous Cell Carcinoma with and without Association of Inverted Papilloma: A Multi-Institutional Analysis

Abstract: Although SCC with and without IP association are considered different diseases, their demographics and outcomes seem similar. Nodal metastasis was noted to be higher in the SCC cohort, which may indicate different tumor biology. Further study is warranted.

Cited by 28 publications

References 19 publications

Sinonasal squamous cell carcinoma and EGFR mutations: a molecular footprint of a benign lesion

Sinonasal squamous cell carcinoma and EGFR mutations: a molecular footprint of a benign lesion

Survival outcomes and prognostic factors of squamous cell carcinomas arising from sinonasal inverted papillomas: a retrospective analysis of 120 patients

Comparison of outcomes between patients with de‐novo sinonasal squamous cell carcinoma vs malignant transformations from inverted papillomas

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