Outcomes of Surgical Ablation in Patients With Atrial Fibrillation Undergoing Cardiac Surgeries

PRRX1 Loss‐of‐Function Mutations Underlying Familial Atrial Fibrillation

“…Previous epidemiological investigations have revealed that AF is frequently associated with various structural heart diseases and systemic comorbidities and other miscellaneous predisposing factors, encompassing congenital heart disease, coronary heart disease, rheumatic heart disease, cardiomyopathy, cardiac and noncardiac surgery, essential hypertension, hyperthyroidism, diabetes, chronic obstructive pulmonary disease, chronic kidney disease, inflammation, obstructive sleep apnea, imbalanced serum electrolytes, obesity, and unhealthy lifestyle. 1 , 20 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 However, in up to 30% of AF cases, AF occurs in the absence of the above‐mentioned, well‐recognized cardiac conditions or modifiable risk precipitants (termed as idiopathic AF). 2 Recently, increasing studies have demonstrated substantial familial clustering of AF, with the heritability of AF being as high as 62%, which highlights a strong genetic component underlying AF.…”