Outcomes of Surveillance for Contralateral Breast Cancer in Patients Less than Age 60 at the Time of Initial Diagnosis

Weinstock, Chana; Bigenwald, R.; Hochman, Tsivia; Park, Sun; Narod, S. A.

doi:10.3747/co.19.890

Cited by 9 publications

(1 citation statement)

References 27 publications

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“…A number of improvements in treatment during this period have undoubtedly contributed to the improved survival rate. Previous studies have shown sex, BMI and initial pathologic diagnosis age differences in the pathophysiology, clinical presentation and treatment response of cancers, such as head and neck cancer, endometrial cancer and breast cancer ( 10 , 44 , 58 ). In the present study, we systemically investigated the effect of sex, BMI and initial pathologic diagnosis age on two- and five-year survival rates for each of the 38 different types of cancer in TCGA.…”

Section: Discussionmentioning

confidence: 99%

Impact of sex, body mass index and initial pathologic diagnosis age on the incidence and prognosis of different types of cancer

et al. 2018

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Cancer represents a significant challenge for humankind, as early diagnosis and treatment are difficult to achieve. To systemically investigate the effect of sex, body mass index (BMI) and age on cancer incidence and prognosis, the data from 14,504 cases of cancer were downloaded from The Cancer Genome Atlas (TCGA). BMI was used to categorize each person as underweight, normal weight, overweight or obese. Two- and five-year survival rates were applied to estimate the prognosis for each cancer type. All data were statistically analyzed. We identified that males were more susceptible to lung, liver and skin cancer when compared with females, whereas females were more susceptible to thyroid, breast and adrenal cortex cancer. High BMI (>25) was positively associated with the occurrence of cancer, although patients with high BMI at the time of initial diagnosis had higher two/five-year survival rates. The survival rates for cancer were positively correlated with the age at initial pathologic diagnosis. Some types of cancer were associated with particularly young ages of onset, including adrenocortical carcinoma, cervical and endocervical cancers, brain lower grade glioma, pheochromocytoma and paraganglioma, testicular germ cell tumors and thyroid carcinoma. Hence, the early diagnosis and prognosis for these cancers need to be improved. In conclusion, sex, BMI and age are associated with the incidence and survival rates for cancers. These results could be used to supplement precision and personalized medicine.

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Section: Discussionmentioning

confidence: 99%

Impact of sex, body mass index and initial pathologic diagnosis age on the incidence and prognosis of different types of cancer

et al. 2018

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The incidence of bone metastasis after early-stage breast cancer in Canada

Liede

Jerzak

Hernandez

et al. 2016

Breast Cancer Res Treat

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Current information on the incidence and prevalence of bone metastases in women with breast cancer is scarce. This study examined the occurrence and predictors of bone metastases, as well as post-metastasis survival in a prospective cohort of Canadian women with breast cancer. We included women treated for early-stage (stage I, II, or III) breast cancer at the Henrietta Banting Breast Centre (HBBC) in Toronto, Canada between 1987 and 2000. Data were abstracted from medical records and pathology reports in the HBBC database; follow-up extended to end of data availability or August 31, 2015. Actuarial survival analyses provided cumulative incidence of bone metastases at 5, 10, and 15 years after breast cancer diagnosis. Kaplan-Meier curves describe breast cancer mortality. Regression models assessed patient, tumor, and treatment characteristics as predictors of bone metastases with all-cause mortality as a competing risk. Among 2097 women studied, the 5-, 10-, and 15-year probability of bone metastasis was 6.5, 10.3, and 11.3 % for the first recurrence, and 8.4, 12.5, and 13.6 % for any bone recurrence. At median follow-up (12.5 years), 13.2 % of patients had bone metastases. Median survival was 1.6 years following bone metastasis, and shorter if both bone and visceral metastases occurred. Advanced age and adjuvant treatment with tamoxifen were protective against bone metastasis. In this representative cohort of women diagnosed with early-stage breast cancer in Ontario, Canada, with long follow-up, the incidence of bone metastases was consistent with longitudinal studies from the United Kingdom, Denmark, and the US.

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Predictors associated with MRI surveillance screening in women with a personal history of unilateral breast cancer but without a genetic predisposition for future contralateral breast cancer

Hegde

Wang

Attai

et al. 2017

Breast Cancer Res Treat

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Outcomes of Surveillance for Contralateral Breast Cancer in Patients Less than Age 60 at the Time of Initial Diagnosis

Cited by 9 publications

References 27 publications

Impact of sex, body mass index and initial pathologic diagnosis age on the incidence and prognosis of different types of cancer

Impact of sex, body mass index and initial pathologic diagnosis age on the incidence and prognosis of different types of cancer

The incidence of bone metastasis after early-stage breast cancer in Canada

Predictors associated with MRI surveillance screening in women with a personal history of unilateral breast cancer but without a genetic predisposition for future contralateral breast cancer

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