Outcomes of synchronous pulmonary nodules detected on computed tomography in head and neck cancer patients: 12-year retrospective review of a consecutive cohort

Zammit-Maempel, I; Kurien, Regi; Paleri,

doi:10.1017/s0022215116000736

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…In the present study, 3.8% of initially indeterminate index nodules were subsequently demonstrated to represent malignant disease. Our results are similar to our previous finding of a 6% malignancy rate in pulmonary nodules but are significantly lower than multiple previous reports 12–15 . One reason for the discrepancies in older papers and our work along with our contemporaries could be the improvements made in CT imaging which may allow for smaller pulmonary nodules to be detected.…”

Section: Discussionsupporting

confidence: 86%

Analysis of the interactions between small pulmonary nodules, clinical factors and the risk of malignancy in the chest following diagnosis of head and neck cancer

Macmillan

Hopkins

Gomati

et al. 2022

Clinical Otolaryngology

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Background This study aims to investigate radiological and clinical factors which predict malignancy in indeterminate pulmonary nodules in patients with head and neck cancer (HNC). Methods Prospective data were collected in 424 patients who were reviewed in the NHS Lothian HNC multidisciplinary meeting from May 2016 to May 2018. Staging and follow‐up CT chest imaging were reviewed to identify and assess pulmonary nodules in all patients. Results About 61.8% of patients had at least one pulmonary nodule at staging CT. In total, 25 patients developed malignancy in the chest. Metastatic disease in the chest was significantly associated with unknown or negative p16 status (p < .0005). Pleural indentation and spiculation were associated with indeterminate nodules, subsequently being shown to represent metastatic disease (p > .0005 and p = .046, respectively). Conclusion Negative or unknown p16 status was associated with an increased propensity to develop metastatic disease in the chest in patients with HNC.

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Section: Discussionsupporting

confidence: 86%

Analysis of the interactions between small pulmonary nodules, clinical factors and the risk of malignancy in the chest following diagnosis of head and neck cancer

Macmillan

Hopkins

Gomati

et al. 2022

Clinical Otolaryngology

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“…Four retrospective studies that were not in the BTS guidance warrant discussion. A recent article by Zammit‐Maempel et al found, in patients with recurrent and newly diagnosed head and neck cancers, that 7% of the nodules initially thought to be benign were found to represent malignancy on follow‐up. Those patients with recurrent head and neck cancers were more likely to have malignant changes on chest CT, either metastasis or primary lung cancers.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the incidence and factors predictive of outcome in patients with head and neck cancer with pulmonary nodules

et al. 2017

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“…SPNs are not associated with pulmonary atelectasis, infection, hilar enlargement or enlarged mediastinal lymph nodes. As the rate of detection of early-stage pulmonary malignant tumors increases, one SPN appears in every 500 chest radiographs (2). SPNs are a common manifestation of multiple benign and malignant diseases and are usually asymptomatic.…”

Section: Introductionmentioning

confidence: 99%

Differential diagnosis of solitary pulmonary nodules with dual-source spiral computed tomography

Shi

Wang

2016

Experimental and Therapeutic Medicine

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The aim of the present study was to analyze the value of applying dual-source 64-layer spiral computed tomography (CT) in the differential diagnosis of solitary pulmonary nodules (SPNs). Mediastinal windows from 45 cases were selected to study SPNs (maximum diameter, ≤3 cm), and the pathological nature of lesions was determined by clinical and pathological diagnosis. Conventional 64-layer spiral CT scanning, local enhancement and 3D recombination technologies were used to determine the occurrence rate, lesion diameter, degree of enhancement, lobular sign, spicule sign, pleural indentation sign, vessel convergence sign and bronchus sign. The final diagnoses indicated 34 cases of malignant SPNs (75.6%) and 11 benign cases (24.4%). When the nodule diameter in the malignant group was compared with that of the benign group, the difference was not statistically significant (P>0.05). Nodules in the malignant group showed inhomogeneous enhancement while nodules in the benign group showed homogeneous enhancement. The enhanced CT values in the malignant group were higher than those in the benign group, and the difference was statistically significant (P<0.05). The proportion of nodules with lobular sign in the malignant group was significantly higher than that in the benign group (P<0.05). The proportion of nodules with calcification, vessel convergence sign and bronchus sign in the malignant group were significantly higher than those in the benign group, and the differences were statistically significant (P<0.05). A comparison of vacuole sign, pleural indentation sign, spiculate protuberance and fat occurrence between the two groups yielded no statistically significant differences (P>0.05). The sensitivity of CT enhancement was 85.6%, specificity was 79.6%, positive predicated value was 92.3%, and the negative predicted value was 85.2%. In conclusion, SPNs diagnosed by CT enhancement manifested with enhancement degree, lobular sign, calcification, vessel convergence sign and bronchus sign with high diagnostic accuracy.

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Outcomes of synchronous pulmonary nodules detected on computed tomography in head and neck cancer patients: 12-year retrospective review of a consecutive cohort

Abstract: Chest computed tomography abnormalities in patients with recurrent head and neck cancer are statistically more likely to be malignant. Very few patients with an initially benign-appearing nodule develop chest malignancy over time.

Cited by 7 publications

References 13 publications

Analysis of the interactions between small pulmonary nodules, clinical factors and the risk of malignancy in the chest following diagnosis of head and neck cancer

Analysis of the interactions between small pulmonary nodules, clinical factors and the risk of malignancy in the chest following diagnosis of head and neck cancer

Analysis of the incidence and factors predictive of outcome in patients with head and neck cancer with pulmonary nodules

Differential diagnosis of solitary pulmonary nodules with dual-source spiral computed tomography

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