Outcomes of Transplanting Deceased-Donor Kidneys between Elderly Donors and Recipients

Giessing, Markus; Fuller, T. Florian; Friedersdorff, Frank; Değer, Serdar; Wille, Andreas; Neumayer, Hans‐Hellmut; Schmidt, Danilo; Budde, Klemens; Liefeldt, Lutz

doi:10.1681/asn.2008040423

Cited by 48 publications

(28 citation statements)

References 22 publications

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“…55 However, this does not occur when intact vessels are treated in vitro with calcitriol. 28 These genes are upregulated in aortas after prolonged treatment with calcitriol, 51 but not with acute treatment in a recent report in abstract form, 54 suggesting an indirect effect.…”

Section: Therapies Related To Disordered Bone and Mineral Metabolismmentioning

confidence: 90%

“…53 Recent studies in the latter model, presented in abstract form, showed that doses of calcitriol required to suppress sHPT increased vascular calcification. 54 Paricalcitol, an analog of calcitriol with a relatively lower calcemic effect, appears to produce much less vascular calcification. 51 The mechanism by which active vitamin D affects vascular calcification is unclear.…”

Section: Therapies Related To Disordered Bone and Mineral Metabolismmentioning

confidence: 99%

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Recent progress in the treatment of vascular calcification

O’Neill

Lomashvili

2010

Kidney International

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Vascular calcification is common in patients with advanced chronic kidney disease and is associated with poorer outcomes. Although the pathophysiology is not completely understood, it is clear that it is a multifactorial process involving altered mineral metabolism, as well as changes in systemic and local factors that can promote or inhibit vascular calcification, and all of these are potential therapeutic targets. Current therapy is closely linked to strategies for preventing disordered bone and mineral metabolism in advanced kidney disease and involves lowering the circulating levels of both phosphate and calcium. The efficacy of compounds that specifically target calcification, such as bisphosphonates and thiosulfate, has been shown in animals but only in small numbers of humans, and safety remains an issue. Additional therapies, such as pyrophosphate, vitamin K, and lowering of pH, are supported by animal studies, but are yet to be investigated clinically. As the mineral composition of vascular calcifications is the same as in bone, potential effects on bone must be addressed with any therapy for vascular calcification.

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Section: Therapies Related To Disordered Bone and Mineral Metabolismmentioning

confidence: 90%

Section: Therapies Related To Disordered Bone and Mineral Metabolismmentioning

confidence: 99%

Recent progress in the treatment of vascular calcification

O’Neill

Lomashvili

2010

Kidney International

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“…The Eurotransplant Senior Program had been established with the aim to allocate older kidneys with minimal ischemia times to older recipients termed by some as the “Old for Old” program. Of note, outcomes of older organs transplanted within this program had been comparable to those of younger organs (74). Optimizing allocation schemes and reducing CIT is therefore a strategy that remains relevant, particularly in times when utilization of ECD organs continues to increase.…”

Section: Clinical Implications and Novel Therapiesmentioning

confidence: 86%

Ischemia/Reperfusion Injury and its Consequences on Immunity and Inflammation

et al. 2014

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Ischemia/reperfusion injury (IRI), an inherent component of transplantation, affects organ quality and transplant outcomes. Although the complexity of the pathophysiology is recognized, detailed mechanisms remain unclear, and strategies preventing the consequences of IRI have been challenging. Of critical significance appears the link between IRI, the initiation of innate immune responses, and the (potential) augmentation of adaptive immunity. An improved understanding of those complex mechanisms and interactions may pave the way for more effective treatment strategies.

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“…Beaucoup de ces donneurs âgés sont considérés comme étant à critères élargis (DCE), selon les critères de l'UNOS [26] et bon nombre ne peuvent être proposés à des receveurs jeunes. Accepter et transplanter des reins prélevés chez des donneurs encore plus âgés que les receveurs âgés est une opportunité qui est largement utilisée en Europe, en particulier dans le cadre du Eurotransplant Senior Program [27]. Celui-ci démontre que des reins de donneurs de 75 ans ou plus peuvent être greffés à des receveurs de 65 ans ou plus à 3 conditions : une fonction rénale normale, une absence de comorbidités et une attribution locale.…”

Section: Considérations éThiquesunclassified

Transplantation rénale chez le sujet âgé : expérience française

Kessler

2015

Ethics, Medicine and Public Health

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Outcomes of Transplanting Deceased-Donor Kidneys between Elderly Donors and Recipients

Cited by 48 publications

References 22 publications

Recent progress in the treatment of vascular calcification

Recent progress in the treatment of vascular calcification

Ischemia/Reperfusion Injury and its Consequences on Immunity and Inflammation

Transplantation rénale chez le sujet âgé : expérience française

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