Outcomes of transposition of the great arteries in the era of atrial inflow correction

Birnie, DavidH.; Tometzki, Andrew; Curzio, Joan; Houston, A B; Hood, Stuart; Swan, Lorna; Doig, W. B.; Wilson, Neil; Jamieson, M. P. G.; Pollock, James K.; Hillis, W. S.

doi:10.1136/hrt.80.2.170

Cited by 35 publications

(16 citation statements)

References 13 publications

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“…9,12 Table 2 displays the distribution of various congenital heart lesion diagnoses that lead to heart transplantation within the PHTSG/Cardiac Transplant Research Database. 66 Singleventricle lesions, [67][68][69][70] D-transposition of the great vessels (especially after the Mustard or Senning procedure), 71,72 and corrected or L-transposition of the great vessels, 73 lesions known to be associated with risk of ongoing deterioration into adulthood, are not surprisingly common diagnoses that lead to heart transplantation.…”

Section: Congenital Heart Diseasementioning

confidence: 99%

Indications for Heart Transplantation in Pediatric Heart Disease

Canter¹,

Shaddy²,

Bernstein³

et al. 2007

Circulation

261

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Background— Since the initial utilization of heart transplantation as therapy for end-stage pediatric heart disease, improvements have occurred in outcomes with heart transplantation and surgical therapies for congenital heart disease along with the application of medical therapies to pediatric heart failure that have improved outcomes in adults. These events justify a reevaluation of the indications for heart transplantation in congenital heart disease and other causes of pediatric heart failure. Methods and Results— A working group was commissioned to review accumulated experience with pediatric heart transplantation and its use in patients with unrepaired and/or previously repaired or palliated congenital heart disease (children and adults), in patients with pediatric cardiomyopathies, and in pediatric patients with prior heart transplantation. Evidence-based guidelines for the indications for heart transplantation or retransplantation for these conditions were developed. Conclusions— This evaluation has led to the development and refinement of indications for heart transplantation for patients with congenital heart disease and pediatric cardiomyopathies in addition to indications for pediatric heart retransplantation.

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Section: Congenital Heart Diseasementioning

confidence: 99%

Indications for Heart Transplantation in Pediatric Heart Disease

Canter¹,

Shaddy²,

Bernstein³

et al. 2007

Circulation

261

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“…We have not described data on operation technique. Several studies have shown that the type of operation, the year of birth, and era of operation influence late outcome in Mustard and Senning patients (9,10). To exclude the influence of these factors, we matched SD cases and controls for these variables and have, in addition, used controls operated and followed-up in the same center and surgeon as the corresponding SD case.…”

Section: Discussionmentioning

confidence: 99%

“…While their survival rate has been good (1-7), arrhythmia, right ventricular (RV) dysfunction, and late death are well-recognized complications (1)(2)(3)(4)(5)(6)(7)(8)(9). One cause of late death is sudden death (SD) with an incidence of 2% to 15% (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). It was the most common cause of late death in some studies (1,2,8).…”

mentioning

confidence: 97%

Predictors of sudden cardiac death after mustard or senning repair for transposition of the great arteries

Kammeraad

Deurzen

Sreeram

et al. 2004

Journal of the American College of Cardiology

286

155

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“…[2][3][4][5][6][7][8][9][10][11][12][13] All but one of these 12 collected data from single centres, thus overlooking the variability inherent in clinical practice, in particular the different surgical techniques applied in these cases. Moreover, the follow up period in most of these studies was limited to approximately 20 years after atrial repair.…”

mentioning

confidence: 99%

Long term outcome up to 30 years after the Mustard or Senning operation: a nationwide multicentre study in Belgium

Moons

Gewillig²,

Sluysmans

et al. 2004

Heart

221

150

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Objective: To assess long term outcome of patients who underwent Mustard or Senning repair for transposition of the great arteries up to 30 years earlier.Design: Retrospective review of medical records.Setting: The six university hospitals in Belgium with paediatric cardiology departments.Patients: 339 patients were reviewed, of whom 124 underwent the Mustard procedure and 215 the Senning procedure. This represents almost the entire population of patients in Belgium with either simple or complex transposition.Main outcome measures: Mortality, morbidity, functional abilities, social integration.Results: Overall mortality was 24.2%. Early mortality (⩽ 30 days after surgery) accounted for 16.5%, late mortality for 7.7%. Actuarial survival of early survivors at 10, 20, and 30 years after surgery was 91.7%, 88.6%, and 79.3%, respectively. Patients in the Senning cohort had a slightly better survival rate than those in the Mustard cohort (NS). Baffle obstruction occurred more often after Mustard repair (15.3%) than after the Senning procedure (1.4%). Arrhythmia-free survival did not differ between the two cohorts, but was determined by the complexity of the transposition. Survivors of the Senning cohort had better functional status, and tended to engage in more sports activities.Conclusions: The long term outcome for patients surviving the Mustard or Senning operation was favourable in terms of late mortality, morbidity, functional, and social status. Overall mortality in the Senning cohort did not differ from the Mustard group, but Senning patients had better functional status, greater participation in sports activities, and fewer baffle related problems.

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Outcomes of transposition of the great arteries in the era of atrial inflow correction

Abstract: Objective-To examine long term morbidity and mortality following atrial inflow corrective procedures for transposition of the great arteries (TGA) and to investigate factors that influence morbidity and mortality.

Cited by 35 publications

References 13 publications

Indications for Heart Transplantation in Pediatric Heart Disease

Indications for Heart Transplantation in Pediatric Heart Disease

Predictors of sudden cardiac death after mustard or senning repair for transposition of the great arteries

Long term outcome up to 30 years after the Mustard or Senning operation: a nationwide multicentre study in Belgium

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