Outcomes of treatment pathways in outpatient treatment of low risk febrile neutropenic cancer patients

Escalante, Carmen P.; Weiser, Mary Ann; Manzullo, Ellen F.; Benjamin, Robert S.; Rivera, Edgardo; Lam, Tony; Ho, Vivian; Valdres, Rosalie; Lee, Eva Lu; Badrina, Noemi; Fernandez, Sally; DeJesus, Yvette; Rolston, Kenneth V. I.

doi:10.1007/s00520-004-0613-6

Cited by 32 publications

(32 citation statements)

References 19 publications

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“…4,[15][16][17][18]24 The oral regimens studied generally con- sisted of an early-generation quinolone with limited gram-positive activity (e.g. ofloxacin, ciprofloxacin) in combination with another agent (e.g.…”

Section: Discussionmentioning

confidence: 99%

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Once daily, oral, outpatient quinolone monotherapy for low‐risk cancer patients with fever and neutropenia

Rolston

Manzullo

Elting

et al. 2006

Cancer

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Nucleation of isotactic polypropylene (iPP) crystallization by gold (Au) nanoparticles was studied. Regardless of their size, 4.3, 8.8, 28.3, and 84.5 nm, all particles were able to nucleate spherulites when deposited on the iPP surface. However, when added and melt‐mixed with iPP, only the smallest particles affected significantly the iPP bulk crystallization. Au nanoparticles larger than 4.3 nm, at the concentration of 0.001 wt %, did not influence the crystallization of iPP. Contrary to this, 0.001 and 0.005 wt % of Au nanoparticles having the size of 4.3 nm increased crystallization temperature of the iPP by 7–8 °C and decreased markedly the sizes of polycrystalline aggregates. Aggregation of Au nanoparticles in the polymer matrix was evidenced by electron microscopy and contributed to their decreased effectiveness in the nucleation of iPP crystallization. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 469–478, 2010

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Section: Discussionmentioning

confidence: 99%

“…There were 21 women and 19 men with a median age of 44 years (range, 20-71 years). The median MASCC score was 24 (range, [16][17][18][19][20][21][22][23][24][25][26]. 7 Four patients had MASCC scores Ͻ21.…”

Section: Patient Characteristicsmentioning

confidence: 99%

Once daily, oral, outpatient quinolone monotherapy for low‐risk cancer patients with fever and neutropenia

Rolston

Manzullo

Elting

et al. 2006

Cancer

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“…16 -19 Based on this experience, we developed clinical pathways for outpatient therapy in low-risk patients with neutropenia who were treated at our institution. 20 For this report, we pooled the data from our clinical trials and institutional pathways, so that we could describe the nature and spectrum of infections seen in low-risk, febrile neutropenic patients.…”

Section: Discussionmentioning

confidence: 99%

Bacterial infections in low‐risk, febrile neutropenic patients

Kamana

Escalante

Mullen

et al. 2005

Cancer

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Finger length ratio has been proposed as a putative marker for prenatal hormone exposure, as well as the action of HOX, AR, and a variant of the LIN28b genes. These genes have been recently connected to carcinogenesis and digit ratio could help to identify patients with this predisposition. Objectives: The purpose of this study was to investigate the possible correlations between digit ratio, oral squamous cell carcinoma (OSCC)—the most common oral cancer—and oral premalignant lesions (OPLs) in tobacco‐consuming males, the main risk group for this disease. Methods: Digital images of the right hands of patients diagnosed with OSCC (n = 25), OPLs (n = 25), and age‐matched controls (n = 25) were obtained. Fingers were measured using Adobe Photoshop® and the mean ratios between the 2nd and 4th digits were compared. Data were analyzed by ANOVA (α = 0.05). Results: Risk factors (alcohol and tobacco consumption, familial history) were similar between the three study groups. Males in the OSCC group presented significantly higher digit ratio (P = 0.03) in comparison with males with OPLs and individuals without oral lesions. Conclusions: According to the results, males with the higher digit ratio seem to be more prone to undergo malignization of lesions in the oral cavity. Similar deleterious habits for the three groups allows us to infer that digit ratio could add to the research of etiological factors and be a putative marker for the screening of patients' susceptibility to develop oral squamous cell carcinoma. Am. J. Hum. Biol. 2011. © 2011 Wiley‐Liss, Inc.

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“…De esta forma, el trabajo de Escalante 64 encontró que las únicas variables asociadas al fracaso del tratamiento ambulatorio eran: edad ≥ 70 años, PS≥ 2, mucositis > grado 2 y neutrófilos <100. Notablemente, la edad avanzada es la única variable común con el sistema Mascc.…”

Section: Factores Pronósticos En Ensayos De Tratamiento Ambulatoriounclassified

“…En estos trabajos no se encontraron diferencias significativas respecto a tasas de eficacia y seguridad 16 . No obstante, existe alguna evidencia de que las variables predictivas importantes en el domicilio pueden ser diferentes a las que se utilizan en el hospital 64 . El número de pacientes reclutados ha sido bajo, por lo que es difícil efectuar análisis de subgrupos.…”

Section: Conclusionesunclassified

Neutropenia febril: análisis de los factores pronósticos y el tratamiento adaptado al riesgo. Revisión crítica

et al. 2006

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ResumenLos pacientes con neutropenia febril constituyen una población heterogénea. La tendencia actual de la mayoría de los grupos de trabajo consiste en tratar de ofrecer un tratamiento individualizado adaptado al riesgo de complicaciones. El aspecto más crítico se basa en encontrar las variables adecuadas para seleccionar a los enfermos de bajo riesgo. Desafortunadamente, los sistemas pronósticos más utilizados presentan una tasa de errores que se puede considerar inaceptable. Este estudio pretende analizar todos los factores pronósticos implicados en la confección de un algoritmo de tratamiento adaptado al riesgo, que incluya el manejo ambulatorio. Los factores pronósticos evaluados comprenden los sistemas clásicos de Talcott y Mascc, cuya utilidad pronóstica puede resultar controvertida. Además se analizan los fundamentos clínicos y microbiológicos de la neutropenia febril, y se propone la integración de todos estos datos, para conseguir una mayor fiabilidad en la evaluación de los pacientes.

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Outcomes of treatment pathways in outpatient treatment of low risk febrile neutropenic cancer patients

Cited by 32 publications

References 19 publications

Once daily, oral, outpatient quinolone monotherapy for low‐risk cancer patients with fever and neutropenia

Once daily, oral, outpatient quinolone monotherapy for low‐risk cancer patients with fever and neutropenia

Bacterial infections in low‐risk, febrile neutropenic patients

Neutropenia febril: análisis de los factores pronósticos y el tratamiento adaptado al riesgo. Revisión crítica

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